Radicinin from Cochliobolus sp. inhibits Xylella fastidiosa , the causal agent of Pierce’s Disease of grapevine

Aldrich, Thomas J.; Rolshausen, Philippe E.; Roper, M. Caroline; Reader, Jordan M.; Steinhaus, Matthew J.; Rapicavoli, Jeannette N.; Vosburg, David A.; Maloney, Katherine N.

doi:10.1016/j.phytochem.2015.03.015

Cited by 40 publications

(43 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar cases have been found; Vitis vinifera plants also display differences in disease severity and symptoms, and this was shown to be due to the presence of endophytic fungi, such as Cochliobolus sp., which inhibited X. fastidiosa by producing the antimicrobial radicinin. The absence of these fungi may result in the emergence of X. fastidiosa as a pathogen (Aldrich et al ., 2015). Additionally, studies (Dourado et al ., 2013, 2015; Lacava et al ., 2004, 2006a) have shown that the development of CVC symptoms in citrus plants could be a result of an unbalanced endophytic population, including Methylobacterium spp.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The diversity of citrus endophytic bacteria and their interactions with Xylella fastidiosa and host plants

2016

View full text Add to dashboard Cite

The bacterium Xylella fastidiosa is the causal agent of citrus variegated chlorosis (CVC) and has been associated with important losses in commercial orchards of all sweet orange [Citrus sinensis (L.)] cultivars. The development of this disease depends on the environmental conditions, including the endophytic microbial community associated with the host plant. Previous studies have shown that X. fastidiosa interacts with the endophytic community in xylem vessels as well as in the insect vector, resulting in a lower bacterial population and reduced CVC symptoms. The citrus endophytic bacterium Methylobacterium mesophilicum can trigger X. fastidiosa response in vitro, which results in reduced growth and induction of genes associated with energy production, stress, transport, and motility, indicating that X. fastidiosa has an adaptive response to M. mesophilicum. Although this response may result in reduced CVC symptoms, the colonization rate of the endophytic bacteria should be considered in studies that intend to use this endophyte to suppress CVC disease. Symbiotic control is a new strategy that uses symbiotic endophytes as biological control agents to antagonize or displace pathogens. Candidate endophytes for symbiotic control of CVC must occupy the xylem of host plants and attach to the precibarium of sharpshooter insects to access the pathogen. In the present review, we focus on interactions between endophytic bacteria from sweet orange plants and X. fastidiosa, especially those that may be candidates for control of CVC.

show abstract

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The diversity of citrus endophytic bacteria and their interactions with Xylella fastidiosa and host plants

2016

View full text Add to dashboard Cite

show abstract

“…6‐Methoxymellein is a phytoalexin (with a dihydro‐isocoumarin skeleton), which accumulates in carrots . Radicinin is isolated Alternaria radicina , which is a seed borne fungal pathogen . Fungerin is produced by Fusarium sp .…”

Section: Tacrine (Tha) and Medical Plants In The Treatment Of Admentioning

confidence: 99%

Phyto‐Tacrine Hybrids as Promising Drugs to Treat Alzheimer's Disease

Girek

2019

ChemistrySelect

View full text Add to dashboard Cite

Alzheimer's disease is an incurable neurodegenerative disease which represents the most common form of dementia. Cognition impairment and memory loss are mostly caused by reduced levels of the neurotransmitter acetylcholine. Therefore, current drug therapies are based on the cholinergic hypothesis. However, β‐amyloid hypothesis is getting more important in last years. For many years, one of the basic drugs for the treatment of Alzheimer's disease was tacrine, acetylcholinesterase inhibitor. Unfortunately, it was withdrawn from the market due to its side effects. To diminish side effects, research has focused on obtaining multi‐target‐directed ligands, which target numerous disease pathways simultaneously, including those of Alzheimer's disease. The comprehensive review is focused on the outcomes of the studies of phyto‐tacrine hybrids. Hybrids can inhibit cholinesterase and β‐amyloid aggregation. Additionally, phyto‐hybrids have neuroprotective, anti‐inflammatory, hepatoprotective and metal chelating properties. Further research is necessary for the development of hybrids to find a proper therapy for Alzheimer's disease.

show abstract

“…The dictyobispyrones possess an unprecedented α,α‐bispyrone skeleton. Reports of bispyrone‐type compounds are rare in nature, with just a few α,γ‐bispyrone examples known …”

Section: Other Compoundsmentioning

confidence: 99%

“…Reports of bispyrone-type compounds are rare in nature,w ith just af ew a,g-bispyrone examples known. [61] Dictyobispyrones B( 168)a nd E( 169)w ere synthesized by nucleophilic addition of alkyne 162 to (S)-propylene oxide 161, followed by protection of the resultant hydroxyl group to afford ether 163.C ondensation of alkyne 163 with either b-ketoester 164 or b-ketoester 165 afforded pyrones 166 and 167, respectively.T reatmento ft he latter compounds with p-toluenesulfonic acid resulted in cyclization to the final compounds, dictyobispyrones B( 168)a nd E( 169).…”

Section: Dictyobispyronesmentioning

confidence: 99%

Natural Products from Social Amoebae

Barnett

Stallforth

2017

Chemistry A European J

View full text Add to dashboard Cite

Natural products are invaluable sources of structural diversity and complexity ideally suited for the development of therapeutic agents. The search for novel bioactive molecules has prompted scientists to explore various ecological niches. Microorganisms have been shown to constitute such an important source. Despite their biosynthetic potential, social amoebae, that is, microorganisms with both a uni- and multicellular lifestyle, are underexplored regarding their secreted secondary metabolome. In this review, we present the structural diversity of amoebal natural products and discuss their biological functions as well as their total syntheses.

show abstract

Radicinin from Cochliobolus sp. inhibits Xylella fastidiosa , the causal agent of Pierce’s Disease of grapevine

Cited by 40 publications

References 47 publications

The diversity of citrus endophytic bacteria and their interactions with Xylella fastidiosa and host plants

The diversity of citrus endophytic bacteria and their interactions with Xylella fastidiosa and host plants

Phyto‐Tacrine Hybrids as Promising Drugs to Treat Alzheimer's Disease

Natural Products from Social Amoebae

Contact Info

Product

Resources

About