Radicular Cyst: An Update of the Biological Factors Related to Lining Epithelium

Bernardi, Lisiane; Visioli, Fernanda; Nör, Carolina; Rados, Pantelis Varvaki

doi:10.1016/j.joen.2015.08.036

Cited by 49 publications

(57 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study by Mass, et al presenting 32 children with radicular cysts, reported that all cysts were related to primary molars. The clinical feature of most of the patients was swelling and pain [5]. In this report, each case presented different clinical features and radiographic characteristics.…”

Section: Anamnesis Revealed No Important Systemic Diseasesmentioning

confidence: 72%

“…According to Bernardi, et al [5], the mechanism to develop radicular cyst includes pulp necrosis, colonization and proliferation of microorganisms within the root canal system, release of bacteria toxins and inflammatory mediators into the periapical region and a combination of factors involving epithelial-stromal interaction. The periradicular inflammation leads to proliferation of epithelial cell rests [5].…”

mentioning

confidence: 99%

“…Radicular cysts and periapical granulomas have a similar radiographic appearance; however, radicular cysts are less common and often larger [8]. Various treatment options include root canal therapy, cyst enucleation, extraction of the affected tooth and marsupialization for the decompression of larger cysts [4,5]. This paper related two cases of children with radicular cysts associated to primary molars, with different characteristics.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Radicular Cysts in Primary Dentition with Different Clinical and Radiographic Characteristics

Silva¹

2017

Clin Med Rev Case Rep

View full text Add to dashboard Cite

Radicular cysts are considered rare in primary dentition. The aim of this article was to present two cases of radicular cysts associated to primary molars with different characteristics. Two children sought care at a dental clinic with complaints of a painless swelling and the absence of a premolar, respectively. The first case was a seven-year-old boy who complained of an increased volume in the region of the mandibular right primary second molar. The second case was a 12-year-old girl, who complained of the absence of the mandibular right second premolar and gingival inflammation. In both cases, surgery was performed to remove the lesion and the elements involved. Histological examinations confirmed the radicular cysts. After six months, complete regression of the lesions was reported, and the patients were referred for orthodontic treatment. Radicular cysts can cause damage to the elements involved, adjacent teeth and the occlusion of the patient.

show abstract

Section: Anamnesis Revealed No Important Systemic Diseasesmentioning

confidence: 72%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Radicular Cysts in Primary Dentition with Different Clinical and Radiographic Characteristics

Silva¹

2017

Clin Med Rev Case Rep

View full text Add to dashboard Cite

show abstract

“…Substantial evidence suggests that these lesions are the result of a long-term endodontic infection or pulp necrosis leading to a progressive immune/inflammatory response, whose persistence in periapical tissues can result in the resorption of the surrounding bone and reactivation of epithelial cell rests of Malassez 10,21,22 ; which are probably the main source of the epithelial lining of radicular cysts. 9 In fact, it seems that this persistent, chronic inflammation and destruction of bone depends on the inability of a host defense to eradicate the infection. 10 The participants in this study were predominantly females, aged 20-40 years, and exhibited a well-demarcated radiolucency image, and asymptomatic lesions affecting the anterior maxilla.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Several immune/inflammatory mediators and proteases may be involved in the formation of periapical granulomas and radicular cysts, such as transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9). 8,9 TGF-β1 is a polypeptide member of the transforming growth factor-β superfamily of cytokines, which is secreted by platelets and inflammatory cells. It performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, apoptosis and inflammation, as well as tissue repair.…”

Section: Declaration Of Interestmentioning

confidence: 99%

Immunohistochemical expression of TGF-β1 and MMP-9 in periapical lesions

et al. 2017

View full text Add to dashboard Cite

The objective of this study was to evaluate the expression of matrix metalloproteinase 9 (MMP-9) and transforming growth factor beta (TGF-β1) in periapical lesion samples correlated with the intensity of the inflammatory infiltrate and thickness of the epithelial lining. Forty-five cases of periapical lesions (23 periapical granulomas and 22 radicular cysts) were subjected to morphological and immunohistochemical analyses using anti-MMP-9 and anti-TGF-β1 antibodies. The data were analyzed using the following tests: non-parametric Mann-Whitney, chi-square, Fisher's exact test and Spearman's correlation test (P<0.05). Analysis of inflammatory infiltrate revealed that 78% of periapical granulomas presented infiltrate grade III, in contrast with 32% of radicular cysts (P<0.001). Morphological evaluation of the epithelial thickness in radicular cysts revealed the presence of atrophic epithelium in 86% of the cysts. The immunostaining of MMP-9 was score 2 in 67% of the granulomas and 77% of the cysts. Both lesions were predominantly score 1 for TGF-β1. Significant differences were confirmed between the expression scores of TGF-β1 and MMP-9 in periapical granulomas (p = 0.004) and in radicular cysts (p < 0.001). Expression of TGF-β1 was different for periapical granulomas and radicular cysts. This immunoregulatory cytokine seems more representative in asymptomatic lesions. The extracellular matrix remodeling process dependent on MMP-9 seems to be similar for both periapical granulomas and radicular cysts. TGF-β1 and MMP-9 may play an important role in the maintenance of periapical lesions.

show abstract

Bibliography

2022

Shear's Cysts of the Oral and Maxillofacial Regions

View full text Add to dashboard Cite

Radicular Cyst: An Update of the Biological Factors Related to Lining Epithelium

Cited by 49 publications

References 50 publications

Radicular Cysts in Primary Dentition with Different Clinical and Radiographic Characteristics

Radicular Cysts in Primary Dentition with Different Clinical and Radiographic Characteristics

Immunohistochemical expression of TGF-β1 and MMP-9 in periapical lesions

Bibliography

Contact Info

Product

Resources

About