Radio-frequency-heating capability of silica-coated manganese ferrite nanoparticles

Abstract

MnFe2O4 nanoparticles (NPs) with various sizes and tight size-distribution were synthesized by a chemical solution-phase method. The as-synthesized NPs were coated with a silica shell of 4 nm–5 nm in thickness, enabling the water-solubility and biocompatibility of the NPs. The MnFe2O4 NPs with a size of less than 18 nm exhibit superparamagnetic behavior with high saturated magnetization. The capacity of the heat production was enhanced by increasing particle sizes and radio frequency (RF) field strengths. MnFe2O4/SiO2 NPs with 18-nm magnetic cores showed the highest heat-generation ability under an RF field. These MnFe2O4/SiO2 NPs have great potentiality to cancer treatments, controlled drug releases, and remote controls of single cell functions.

Magnetic silica nanocomposites for magnetic hyperthermia applications

“…Zhang magnetic core showed a much higher SAR value than those of the 12 nm cores. When the core sizes were larger than 18 nm, these NPs tended to aggregate in the solution due to the magnetic interaction [64].…”

Thermoanalytical techniques

“…Magnetic manganese ferrite-silica nanocomposites and similar to them can be used as efficient adsorbents and catalysts [7,8] and can be functionalized with various functional groups, offering a high potential for different applications [9]. Also, MnFe 2 O 4 /SiO 2 nanoparticles have great potential for cancer treatments, controlled drug releases, and remote controls of single cell functions [10].…”

“…Nanocomposites of manganese ferrite nanoparticles dispersed in a silica matrix have been successfully synthesized using different variants of the sol-gel route [6,9,10,12,13].…”