Radio-opaque pellets as faecal markers for faecal fat estimation in malabsorption.

Simpson, F G; Hall, Gilbert; Kelleher, J.; Losowsky, M. S.

doi:10.1136/gut.20.7.581

Cited by 20 publications

(2 citation statements)

References 16 publications

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“…Faecal fat was estimated in the stool5 and the result adjusted for marker recovery. 6 Serum optical density was measured within seven hours of collection and the maximum increase recorded at room temperature with a Perkin Elmer spectrophotometer at 620 nm using the fasting sample as blank.…”

Section: Methodsmentioning

confidence: 99%

Comparison of simple screening tests for fat malabsorption.

West¹,

Levin²,

Griffin³

et al. 1981

BMJ

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Three tests were evaluated as screening procedures for fat malabsorption-namely, measurement of serum optical density, serum triglyceride concentration, and '4CO2 breath excretion after the administration of a 60 g fat meal containing 10 ltCi glycerol tri[l-_4C]oleate. The results of these tests were compared with fat excreted in a three-day faecal collection after adjustment for completeness of collection as assessed by using nonabsorbable radio-opaque markers. Fifty-two patients with various symptoms and eight normal subjects were studied. The maximum increase in serum optical density or triglyceride concentration above the fasting value discriminated poorly between subjects with normal and increased adjusted faecal fat excretion. In contrast, seven-or eight-hour cumulative 54CO, breath excretion provided good discrimination with only four (7%) falsepositive and no false-negative results.The simplicity and convenience of breath analysis make it an attractive alternative to analysis of faecal fat excretion in screening for fat malabsorption.

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Section: Methodsmentioning

confidence: 99%

Comparison of simple screening tests for fat malabsorption.

West¹,

Levin²,

Griffin³

et al. 1981

BMJ

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“…Optimal fat balance can only be achieved if faecal fat output is monitored' and continuous faecal markers should be used if accurate assessment of faecal fat output is to be obtained.2 In the past many different substances have been used for this purpose.3 Polyethylene glycol 4000 is widely used and has been shown to give accurate results for diagnostic purposes in patients not yet receiving treatment. 4 The use of radio-opaque pellets (ROP) has also been advocated on the grounds of simplicity, safety and minimal faecal handling in the laboratory.45…”

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confidence: 99%

Markers for faecal fat estimation in monitoring steatorrhoea in cystic fibrosis.

Gilbert

Kelleher

Walters

et al. 1988

Gut

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SUMMARY Polyethylene glycol (PEG) 4000 is one of numerous substances used as non-absorbable markers to correct for variable faecal output when assessing daily faecal losses of nutrients. The introduction of enteric coated micro-encapsulated pancreatic enzyme (EMPE) preparations has greatly improved the control of fat malabsorption in cystic fibrosis and chronic pancreatitis patients. Unfortunately, these enzyme preparations contain significant quantities of PEG 4000 or polyvinyl pyrolidine (PVP) Radio-opaque pellets were prepared by cutting 1.0-1-5 mm lengths of Portex 2-0 mm internal diameter radio-opaque tubing; these were extracted overnight with toluene to remove the plasticiser and, after drying, were packaged in gelatin capsules, each of which contained eight pellets. For seven days 17 CF patients received 500 mg PEG (Sandoz Products Ltd, London) and eight ROP three times daily, and 11 received only eight ROP three times per day. Normal diet and medication were continued throughout the seven days. During the last 48 hours all stools were collected in separate strong polyethylene bags, which fitted directly on to a commode.Stools were frozen and then x-rayed. Radioopaque pellets were easily distinguished on x-ray films and were counted. The pooled two day collections were then homogenised and analysis was performed for PEG by the method of Malawer6 and for fat by the method of van de Kamer et al.7 Daily faecal fat output was calculated using each marker.

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The Use of Stable Isotope Techniques for Studying Mineral and Trace Element Metabolism in Humans

Walczyk

2012

Isotopic Analysis

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Radio-opaque pellets as faecal markers for faecal fat estimation in malabsorption.

Cited by 20 publications

References 16 publications

Comparison of simple screening tests for fat malabsorption.

Comparison of simple screening tests for fat malabsorption.

Markers for faecal fat estimation in monitoring steatorrhoea in cystic fibrosis.

The Use of Stable Isotope Techniques for Studying Mineral and Trace Element Metabolism in Humans

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