Radiocardiography: A New Method for Studying the Blood Flow Through the Chambers of the Heart in Human Beings

Prinzmetal, Myron; Corday, Eliot; Bergman, H. C.; Schwartz, Lois; Spritzler, R.

doi:10.1126/science.108.2804.340

Cited by 96 publications

(13 citation statements)

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“…However, it nevcr bccamc of major clinical significance itself but is the origin of more advanccd methods to study circulation. In 1948, Prinzmetal et al (24) used an extcrnal GM-tube over the heart region. After a bolus-injection of ''Na, the count-rate was registered and from this curve, named radiocardiogram, the transit time bctween right and left ventricles could bc determined.…”

Section: Diagnostic Methodsmentioning

confidence: 99%

A Glance At The History Of Nuclear Medicine

Carlsson

1995

Acta Oncologica

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Section: Diagnostic Methodsmentioning

confidence: 99%

A Glance At The History Of Nuclear Medicine

Carlsson

1995

Acta Oncologica

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“…[4] The constant, Ki, is defined by the equation, K, = log. 1 -), [5] where SVis the stroke volume and Vi the maximal volume of the chamber. In the symmetrical solution for a series of chambers each with a different Ki, the constant a, takes the following form:…”

Section: Extension Of the Principle To Radiocardiographymentioning

confidence: 99%

A Study of the Pulmonary Blood Volume in Man by Quantitative Radiocardiography*

Giuntini¹,

Lewis²,

Luís³

et al. 1963

J. Clin. Invest.

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Determination of the pulmonary blood volume, as distinguished from the central blood volume, has been hampered by the inaccessibility of the outflow of the pulmonary circulation to sampling. Recently, this difficulty has been circumvented by combined catheterization of the right and left hearts, which allows calculation of pulmonary mean transit time from arterial dilution curves obtained by injection of label into the pulmonary artery and left atrium (1-4). The information thus obtained provides the best available estimate of pulmonary blood volume but is restricted to a relatively small group of patients.A different approach is provided by external counting techniques. Double-peaked curves, named radiocardiograms (5), are obtained by injecting a gamma-emitting label into either a peripheral vein, the right atrium, or the right ventricle, and monitoring its dilution in the cardiac cavities with a scintillation detector collimated over the precordium. It is possible, in most instances, to separate completely the right and left components of radiocardiograms; thus two dilution curves, respectively upstream and downstream to the pulmonary circulation, can be obtained (Figure 1). However, these precordial curves cannot be considered as ordinary dye-dilution curves, since their characteristics depend on the contributions of several circulatory sections. This is particularly true for the left component of radiocardiograms, which, with the type of collimator commonly used, is due, before the time of intracardiac recirculation,

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“…It was introduced in 1948 by Prinz metal (1), who used a precordial Geiger counter for m easure ment of the radioactivity. L ater a scintillation counter was used, but owing to its inadequate collim ation the cardiac output val ues obtained were at first excessively' high (2).…”

Section: By 1 Hakkila and K A Pietilámentioning

confidence: 99%