Studies of Cardiac Output and Pulmonary Blood Volume

Hakkila, J; Pietilä, K

doi:10.1159/000167080

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Hakkila and Pietilk (8) and Eich, Chaffee, and Chodos (10) found values for the peak-to-peak time similar to those reported by Shipley, Clark, Liebowitz, and Krohmer (30), which are approximately 30%v higher than the PMTT of 4.6 seconds found in the present series. As Eich and associates point out, the volume measured on the basis of the peak-to-peak time includes blood contained in both sides of the heart.…”

Section: Discussionsupporting

confidence: 90%

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A Study of the Pulmonary Blood Volume in Man by Quantitative Radiocardiography*

Giuntini¹,

Lewis²,

Luís³

et al. 1963

J. Clin. Invest.

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Determination of the pulmonary blood volume, as distinguished from the central blood volume, has been hampered by the inaccessibility of the outflow of the pulmonary circulation to sampling. Recently, this difficulty has been circumvented by combined catheterization of the right and left hearts, which allows calculation of pulmonary mean transit time from arterial dilution curves obtained by injection of label into the pulmonary artery and left atrium (1-4). The information thus obtained provides the best available estimate of pulmonary blood volume but is restricted to a relatively small group of patients.A different approach is provided by external counting techniques. Double-peaked curves, named radiocardiograms (5), are obtained by injecting a gamma-emitting label into either a peripheral vein, the right atrium, or the right ventricle, and monitoring its dilution in the cardiac cavities with a scintillation detector collimated over the precordium. It is possible, in most instances, to separate completely the right and left components of radiocardiograms; thus two dilution curves, respectively upstream and downstream to the pulmonary circulation, can be obtained (Figure 1). However, these precordial curves cannot be considered as ordinary dye-dilution curves, since their characteristics depend on the contributions of several circulatory sections. This is particularly true for the left component of radiocardiograms, which, with the type of collimator commonly used, is due, before the time of intracardiac recirculation,

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Section: Discussionsupporting

confidence: 90%

“…Several investigators have postulated that an estimate of the pulmonary mean transit time may be derived from precordial curves (6)(7)(8)(9)(10). All the proposed methods, however, lead to a gross overestimation of the pulmonary mean transit time, since they include in it transit times through other circulatory sections.…”

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confidence: 99%