Radiochemical and biological evaluation of novel ¹⁵³Sm/¹⁶⁶Ho‐amino acid–chitosan complexes

Abstract

Ho complexes with the novel amino acid-chitosan polymers, N-(c-propanoylvalin)-chitosan (CHICO-val) and N-(c-propanoyl-aspartic acid)-chitosan (CHICO-asp). The main goal of this study was to obtain data on the radiochemical and biological behaviour of these complexes and information regarding their therapeutic potential when compared to 153 153 Sm complexes was studied in mice. The radioactive amino acid-chitosans can be directly injected into blood stream without significant retention on injection site, being trapped by liver. Biodistribution studies suggest that the radioactive amino acid-chitosans, due to its water solubility and stability may be considered potential candidates to be further explored for liver targeted nuclear therapy.