Radiochemical separation of antimony and tellurium in isotope production and in radionuclide generators

Downs, D. S.; Miller, David A.

doi:10.1023/b:jrnc.0000040881.44068.eb

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…Considering the pnictogen element antimony, only the positron emitter antimony‐118 ( 118 Sb) with its half‐life of 3.6 minutes has been regarded as potentially useful for PET flow studies . Antimony‐118 is available via a tellurium‐118 ( 118 Te)/ 118 Sb generator system . The mother nuclide 118 Te decays with a half‐life of 6 days solely by electron capture with no associated gamma emission.…”

Section: Positron Emitters Of Groups 15 (Pnicogens) and 16 (Chalcogens)mentioning

confidence: 99%

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Labelling with positron emitters of pnicogens and chalcogens

Neumaier

2017

Labelled Comp Radiopharmac

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The increasing importance of the positron emission tomography (PET) in clinical diagnosis led to the development of a multitude of radiotracers labelled with positron‐emitting radionuclides of groups 15 (pnicogens) and 16 (chalcogens) of the periodic table of elements. The positron emitters of the endogenous occurring elements nitrogen, phosphorus, oxygen, and sulphur are characterized by very short half‐lives compared with the most commonly used PET radionuclides carbon‐11 or fluorine‐18. Therefore, the potential of their synthesis and possible applications in PET is challenging and limited. On the other hand, the nonstandard positron emitters arsenic‐72, arsenic‐74, and selenium‐73 have half‐lives in the range of hours to days and, thus, are of interest for PET studies of processes with long biological half‐lives, but novel methods have to be developed for their application, especially in the no‐carrier‐added state. This review summarizes recent research concerning the positron emitters of pnicogens and chalcogens for radiolabelling applications.

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Section: Positron Emitters Of Groups 15 (Pnicogens) and 16 (Chalcogens)mentioning

confidence: 99%

“…[22][23][24] Antimony-118 is available via a tellurium-118 ( 118 Te)/ 118 Sb generator system. 25,26 The mother nuclide 118 Te decays with a half-life of 6 days solely by electron capture with no associated gamma emission.…”

Section: Positron Emitters Of Groups 15 (Pnicogens) and 16 (Chalcogmentioning

confidence: 99%

Labelling with positron emitters of pnicogens and chalcogens

Neumaier

2017

Labelled Comp Radiopharmac

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“…Together, 119 Sb and 117 Sb form a theranostic (therapy and diagnostic) radionuclide pair, facilitating precise measurement of patient specific biodistribution and calculations of in vivo dosimetry. 119 Sb can be produced indirectly via a tellurium generator. − However, direct, no-carrier-added (n.c.a.) production routes of irradiating tin with protons or deuterons avoid medically incompatible eluent systems and dosimetrically problematic tellurium radioisotopes, making the generators difficult to shield. − …”

Section: Introductionmentioning

confidence: 99%

A Third Generation Potentially Bifunctional Trithiol Chelate, Its ^nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (¹¹⁹Sb) from Its Sn Target

et al. 2021

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The therapeutic potential of the Meitner-Auger- and conversion-electron emitting radionuclide 119Sb remains unexplored because of the difficulty of incorporating it into biologically targeted compounds. To address this challenge, we report the development of 119Sb production from electroplated tin cyclotron targets and its complexation by a novel trithiol chelate. The chelation reaction occurs in harsh solvent conditions even in the presence of large quantities of tin, which are necessary for production on small, low energy (16 MeV) cyclotrons. The 119Sb-trithiol complex has high stability and can be purified by HPLC. The third generation trithiol chelate and the analogous stable natSb-trithiol compound were synthesized and characterized, including by single-crystal X-ray diffraction analyses.

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“…The 119 Sb attraction originates from the low energy (∼20 keV) of these Auger electrons, which results in short biological path lengths (∼10 μm) that are comparable with the diameter of a many human cells . Hence, therapeutic targeting with 119 Sb provides a unique opportunity to deliver a lethal dose of radiation to a targeted diseased cell while leaving the adjacent healthy tissue unharmed. − The potential for patient recovery along with little to no hematological toxicity (no negative side-effects) is extraordinary in comparison to nontargeted treatment methods, i.e., nontargeted chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Large-Scale Production of ^119mTe and ¹¹⁹Sb for Radiopharmaceutical Applications

et al. 2019

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Radionuclides find widespread use in medical technologies for treating and diagnosing disease. Among successful and emerging radiotherapeutics, 119 Sb has unique potential in targeted therapeutic applications for low-energy electron-emitting isotopes. Unfortunately, developing 119 Sb-based drugs has been slow in comparison to other radionuclides, primarily due to limited accessibility. Herein is a production method that overcomes this challenge and expands the available time for large-scale distribution and use. Our approach exploits high flux and fluence from high-energy proton sources to produce longer lived 119m Te. This parent isotope slowly decays to 119 Sb, which in turn provides access to 119 Sb for longer time periods (in comparison to direct 119 Sb production routes). We contribute the target design, irradiation conditions, and a rapid procedure for isolating the 119m Te/ 119 Sb pair. To guide process development and to understand why the procedure was successful, we characterized the Te/Sb separation using Te and Sb K-edge X-ray absorption spectroscopy. The procedure provides low-volume aqueous solutions that have high 119m Te—and consequently 119 Sb—specific activity in a chemically pure form. This procedure has been demonstrated at large-scale (production-sized, Ci quantities), and the product has potential to meet stringent Food and Drug Administration requirements for a 119m Te/ 119 Sb active pharmaceutical ingredient.

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Radiochemical separation of antimony and tellurium in isotope production and in radionuclide generators

Cited by 10 publications

References 7 publications

Labelling with positron emitters of pnicogens and chalcogens

Labelling with positron emitters of pnicogens and chalcogens

A Third Generation Potentially Bifunctional Trithiol Chelate, Its ^nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (¹¹⁹Sb) from Its Sn Target

Large-Scale Production of ^119mTe and ¹¹⁹Sb for Radiopharmaceutical Applications

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Radiochemical separation of antimony and tellurium in isotope production and in radionuclide generators

Cited by 10 publications

References 7 publications

Labelling with positron emitters of pnicogens and chalcogens

Labelling with positron emitters of pnicogens and chalcogens

A Third Generation Potentially Bifunctional Trithiol Chelate, Its nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (119Sb) from Its Sn Target

Large-Scale Production of 119mTe and 119Sb for Radiopharmaceutical Applications

Contact Info

Product

Resources

About

A Third Generation Potentially Bifunctional Trithiol Chelate, Its ^nat,1XXSb(III) Complex, and Selective Chelation of Radioantimony (¹¹⁹Sb) from Its Sn Target

Large-Scale Production of ^119mTe and ¹¹⁹Sb for Radiopharmaceutical Applications