Radioembolization in Patients with Progressive Gastrointestinal Stromal Tumor Liver Metastases Undergoing Treatment with Tyrosine Kinase Inhibitors

Response and Overall Survival for Yttrium-90 Radioembolization of Hepatic Sarcoma: A Multicenter Retrospective Study

“…(13,14). TARE of sarcomas has been reported in a few case reports and a small series of gastrointestinal stromal tumors, which suggest that this may also be useful in treating primary and metastatic hepatic STS (11,15,16). The feasibility of treatment of nonresectable primary hepatic STS with transarterial therapies has been demonstrated in several case reports and case series, with survivals in responders ranging from 8-12 months (16)(17)(18).…”

Treatment Options for Metastatic Gastrointestinal Stromal Tumors to the Liver: A Review

“…Rathmann et al performed radioembolization in 11 patients with progressive GIST undergoing treatment with TKI. 65 The majority of patients had a partial response and no patient showed progressive disease after treatment. They concluded the treatment was safe, and challenged the former notion that GISTs may be resistant to radiation therapy.…”

Something old, Something New: Radiation and Immunotherapy in Soft Tissue Sarcoma

“…GIST are relatively radioresistant, one study of 25 patients with GISTs treated with 40 Gy to abdominal sites found two (8%) patients achieved partial remission, 20 (80%) had stable target lesion size for ≥ 3 months after radiotherapy with a median duration of stabilization of 16 months, and 3 (12%) progressed [44]. A series evaluating the role of 90Y in GIST found that among 10 patients treated, 3 patients showed complete response, 5 showed partial response, and 1 showed stable disease on initial imaging [45]. Ultimately, 8 of 9 patients did progress on follow up, with a median progression free interval of 15.9 months (range, 4-29 months).…”