Radiofluoride Photoscanning of Bone for Reticulum Cell Sarcoma

The effect of drug therapy on the uptake of radioactive fluorine by osseous metastases

“…Scintigrams are often positive before roentgenographic demonstration of such lesions is possible. s , 11,19 This increased sensitivity of scintigrams and uptake studies, as compared to roentgen films, is not surprising. Although roentgenographic techniques are, of course, capable of diagnosing both osteoblastic and osteolytic lesions, experiments based on decalcification of whole bones have suggested that 20 to 50 per cent of the calcium must be removed before the loss of calcium is visible roentgenographically in the first place.…”