The effect of drug therapy on the uptake of radioactive fluorine by osseous metastases

Kampffmeyer, Hermann; Dworkin, Howard J.; Carr, Edward G.; Bull, Frances E.

doi:10.1002/cpt196785647

Cited by 9 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Less attention was paid to the possibility of using bone seeking radiopharmaceuticals for assessing the response to therapy of osseous metastases, although radioactivity uptake of metastatic bone lesions has been found to be diminished after irradiation (2,4,7,8), chemotherapy and/or hormonal treatment (3,5,6,10,11,12,13). Work published on this subject has not yet clarified completely the type of scintigraphic changes to be expected in responding patients, because unchanged positive scintigrams were also found during successful treatment of osseous metastases (1,9) and initially, during the first months, some authors even registered an increased uptake after therapy which was followed by a gradual decline (4, 6, 7). The special aim of our examination therefore was to examine the behaviour of 99m Tc-diphosphate concentration in osseous metastases of patients with prostatic cancer during oestrogen and/or cytostatic treatment and with or without previous orchidectomy.…”

Section: Introductionmentioning

confidence: 99%

Serial Bone Scintigraphy for Assessing the Effectiveness of Treatment of Osseous Metastases from Prostatic Cancer

Langhammer¹,

Sintermann²,

G³

et al. 1978

Nuklearmedizin

View full text Add to dashboard Cite

130 serial bone scintigrams were performed to evaluate the course of skeletal metastases under treatment in 36 patients with prostatic cancer. During a successful treatment scintigraphic controls revealed a significant decrease of the metastatic 99mTc-diphosphonate uptake in 14 patients and sometimes even a complete normalization of the skeletal radioactivity distribution, whereas a progression characterized by an increased multifocal radioactivity concentration was registered in 16 patients indicating the failure of the initiated therapy. Based on these results of follow-up studies scintigraphic bone imaging can be recommended for the assessment of the effectiveness of on-going therapy of skeletal metastases.

show abstract

Section: Introductionmentioning

confidence: 99%

Serial Bone Scintigraphy for Assessing the Effectiveness of Treatment of Osseous Metastases from Prostatic Cancer

Langhammer¹,

Sintermann²,

G³

et al. 1978

Nuklearmedizin

View full text Add to dashboard Cite

show abstract

“…These were scanned after appropriate antibiotic or antitumour therapy to see if any changes in uptake had taken place (Kampffmeyer, Dworkin, Carr, and Bull, 1967). …”

Section: Introductionmentioning

confidence: 99%

Strontium-85 Scanning of Suspected Bone Disease

Parsons¹,

Williams²,

Hill³

et al. 1969

BMJ

View full text Add to dashboard Cite

BRIrNm 19that might prove advantageous is the substitution of 5 % dextrose for 0.9 % saline in those patients who are initially hypernatraemic.The values for salicylate clearance given in Table II and Fig. 2 cannot be compared with those of other authors as they are based on total serum salicylate concentrations-as measured by the method of Trinder (1954)-and not on the unbound fraction only. They are presented, nevertheless, because they provide the clinician with a rough estimate of the rate of salicylate excretion that he may obtain with acetazolamide and sodium bicarbonate infusion at any given serum salicylate level. In Fig. 2 creatinine clearance values are also shown, since the glomerular filtration rate is sometimes low in salicylate overdosage and may be further depressed by acetazolamide (Milne, 1963). The effectiveness of the treatment regimen might be limited by this, and also by competition for tubular secretion between acetazolamide and salicylate (Weiner et al., 1959).Although this paper lays greater emphasis on a very high urine pH than a very high urine flow, it is clear that the rate of flow must still be a factor limiting salicylate clearance. When rehydration is not promptly followed by a brisk diuresis the use of an osmotic diuretic may therefore still be of value. We have unpublished data to show that the addition of mannitol to the present treatment regimen can further increase salicylate clearance. It should, however, be borne in mind that mannitol may cause complications of its own (Morgan et al., 1968).It is not suggested that acetazolamide and sodium bicarbonate treatment will replace haemodialysis in the severest cases of salicylate intoxication, for in these there may be other indications for dialysis than the serum salicylate concentration. However, the concentration itself may often be brought down to a safer level during the time required to transfer a patient to a dialysis unit. We have recently treated two such patients prior to dialysis, reducing the serum salicylate in one from 136 to 107 mg./100 ml. in two hours, and in the other from 104 to 69 mg./100 ml. in three hours.

show abstract

Management of pathologic fractures

Pérez

Bradfield

Morgan

1972

Cancer

View full text Add to dashboard Cite

The principles of management of pathologic fractures in the long bones are reviewed, and a series of 45 fractures treated by internal fixation is compared with 26 fractures treated by other nonsurgical procedures. Internal fixation and radiation therapy provide better and longer lasting palliative results in these patients, provided clear indications for this method of management are carefully evaluated. Relief of pain is observed in over 80% of the patients and satisfactory healing and functional results in about 75%. The value of prophylactic fixation and irradiation of large osteolytic lesions in weight‐bearing bones with a high risk of fracture is emphasized.

show abstract

The effect of drug therapy on the uptake of radioactive fluorine by osseous metastases

Cited by 9 publications

References 2 publications

Serial Bone Scintigraphy for Assessing the Effectiveness of Treatment of Osseous Metastases from Prostatic Cancer

Serial Bone Scintigraphy for Assessing the Effectiveness of Treatment of Osseous Metastases from Prostatic Cancer

Strontium-85 Scanning of Suspected Bone Disease

Management of pathologic fractures

Contact Info

Product

Resources

About