Radiofrequency ablation of synchronous bilateral renal cell carcinoma

Abstract

Objectives: The treatment of synchronous bilateral renal cell carcinoma is challenging. Radiofrequency ablation has been increasingly applied in the management of renal tumors. Herein, we report our experience of radiofrequency ablation on 12 patients with synchronous bilateral renal cell carcinoma. Methods: From March 2006 to September 2010, 12 patients with bilateral synchronous sporadic renal cell carcinoma (29 lesions overall) were identified from our kidney database. The mean age was 62.3 years (range 35-81). The mean tumor diameter was 4.5 cm (range 0.9-9.0). Three patients received unilateral radiofrequency ablation and contralateral radical nephrectomy, whereas nine patients received bilateral radiofrequency ablation. The oncological and functional outcomes were analyzed. Contrastenhanced computed tomography examinations were carried out at day 7, and at 3 and 6 months after the procedure, and every 6 months thereafter. Results: The mean follow-up period was 33 months (range 10-64). The local tumor control rate was 93.1% (27/29). Cancer-specific survival and the overall survival rates were 100%. No death or renal failure after the procedure was found. In patients who underwent bilateral radiofrequency ablation, the latest mean glomerular filtration rate had not significantly declined compared with preoperative levels (93.7 Ϯ 13.0 mL/min/ 1.73 m 2 vs 96.9 Ϯ 13.3 mL/min/1.73 m 2 , respectively; P > 0.05). Conclusion: Radiofrequency ablation shows encouraging outcomes in the treatment of bilateral renal cell carcinoma. It can provide adequate local tumor control and cancerspecific survival compared with nephron-sparing surgery while not affecting the renal function.

Synchronous nephron‐sparing approaches for bilateral renal masses: peri‐operative and renal functional outcomes

“…Overall, there are limited data on patients undergoing synchronous bilateral PN. In addition, only one previous study has reported on the use of renal mass ablation for the treatment of bilateral renal masses . As such, the present study provides novel data on outcomes of patients with such bilateral renal tumours.…”

“…If technically feasible, bilateral partial nephrectomies (PNs) are often the preferred strategy because of the benefits of renal functional preservation when compared with radical nephrectomy. More recently, renal mass ablation has emerged as a treatment alternative for patients with renal masses , but there are limited data on the extension of ablative techniques to the treatment of bilateral renal masses .…”

Application and analysis of retroperitoneal laparoscopic partial nephrectomy with sequential segmental renal artery clamping for patients with multiple renal tumor: initial experience

“…To reduce the area of WI, unblocking and segmental renal artery clamping technique was applied. Although the operation demand high equipment quality and operation technique, more and more departments carrying out these techniques in recent years [ 10 – 12 ]. What’s more, our previous study has been demonstrated that patients underwent segmental artery clamping have better early recovery comparing by 3-month postoperative GFR levels [ 13 ].…”

Prognosis and clinicopathological characteristics of renal cell carcinoma: does bilateral occurrence influence overall and cancer-specific survival?

“…Lowrance et al ( 2 ) hypothesized that patients with bilateral RCC have more severe preoperative renal dysfunction than those with unilateral RCC. Balancing preservation of renal function and oncological efficacy is a challenge for urologists managing individuals with bilateral RCC ( 6 ).…”