Radiofrequency ablation versus cryoablation for T1b renal cell carcinoma: a multi-center study

Hasegawa, Takaaki; Yamanaka, Takashi; Gobara, Hideo; Miyazaki, Masaru; Takaki, Haruyuki; Sato, Yozo; Inaba, Yoshitaka; Yamakado, Koichiro

doi:10.1007/s11604-018-0756-x

Cited by 44 publications

(58 citation statements)

References 35 publications

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“…The present study is the third to evaluate functional outcome (D À 4.4 ml/min/1.73m 2 ) after cryoablation for T1b RCC. Hasegawa et al evaluated 23 patients treated by cryoablation for T1b RCC and found a mean eGFR loss of 7.6 ml/min/ 1.73m 2 at 1 month after treatment [4]. Gunn et al [10] evaluated 37 patients treated by cryoablation for T1b RCC and found no significant change in renal function after cryoablation (p > .05).…”

Section: Discussionmentioning

confidence: 99%

“…Despite a higher local recurrence rate, intermediate metastasis-free and cancer-specific survival rates are comparable between the two approaches. RF carries a high risk of repeat ablation for tumors larger than 3 cm [4,5]. Cryoablation is a useful option for large tumors because of the ability to visualize the ablation zone during the procedure, and possibility of complementary treatment [4,6].…”

Section: Introductionmentioning

confidence: 99%

“…RF carries a high risk of repeat ablation for tumors larger than 3 cm [4,5]. Cryoablation is a useful option for large tumors because of the ability to visualize the ablation zone during the procedure, and possibility of complementary treatment [4,6]. Aoun et al [7] demonstrated that tumor size (>3 cm) is not a risk factor for local tumor recurrence after percutaneous cryoablation.…”

Section: Introductionmentioning

confidence: 99%

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Computed tomography-guided percutaneous cryoablation of T1b renal tumors: safety, functional and oncological outcomes

Grange

Tradi

Izaaryene

et al. 2019

International Journal of Hyperthermia

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Purpose: To evaluate the safety, functional and oncological outcomes associated with percutaneous cryoablation of stage T1b renal cell carcinoma (RCC). Materials and methods: Institutional database was reviewed to identify patients treated by percutaneous CT-guidance cryoablation between 2013 and 2018 for biopsy-proven RCC tumors measuring 4.1-7.0 cm. The main outcome parameters analyzed were primary and secondary technique efficacy, progression-free survival (PFS), cancer-specific survival (CSS), loss of estimated glomerular filtration rate (eGFR) and complications. PFS and CSS were estimated by the Kaplan-Meier method. Complications were graded by the Clavien-Dindo system. Results: Twenty-three consecutive patients were included (mean tumor diameter: 45.6 ± 6.2 mm; mean RENAL score: 8.1 ± 1.8). The technical success rate was 95.7%. Primary and secondary technique efficacy rates were 86.3 and 100%, respectively. Three patients found to have incomplete ablations at 3 months were successfully treated by repeat cryoablation. Median duration follow-up was 11 months (range: 3-33). Imaging showed PFS to be 85.7% at 6 months, 66.7% at 12 months and 66.7% at 24 months. One patient with a local recurrence at 12 months was treated by radical nephrectomy. One patient died from progression of disease within 12 months. One patient reported a complication grade ! II (4.3%). Mean eGFR loss was 4.4 ± 8.5 ml/min/1.73m 2 , which was significantly higher among those treated for central tumors (p < .05). Conclusion: Cryoablation for stage T1b renal tumors is technically feasible, with favorable oncological and perioperative outcomes. Longer-term studies are needed to verify our findings. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Computed tomography-guided percutaneous cryoablation of T1b renal tumors: safety, functional and oncological outcomes

Grange

Tradi

Izaaryene

et al. 2019

International Journal of Hyperthermia

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“…The well‐known thermal ablation techniques include radiofrequency ablation, cryoablation and microwave ablation . Previous research comparing radiofrequency ablation with cryoablation for renal tumors showed no significant differences in treatment effects and side‐effects . However, the most recent of those reports stated that when efficacy of the technique was defined as coverage of the tumor by the ablative zone, the primary efficacy rate of the technique was significantly higher in the cryoablation group than in the radiofrequency ablation group …”

Section: Introductionmentioning

confidence: 99%

“…As its efficacy is comparable to nephrectomy, renal cryoablation has become an accepted treatment for small renal tumors as an alternative to surgery, especially in patients who are poor candidates for surgery and patients with multiple renal tumors or a single kidney . In Japan the number of patients undergoing percutaneous cryoablation has been increasing, particularly since its appearance on the list of approved procedures by the Japanese national health insurance program in 2011 …”

Section: Introductionmentioning

confidence: 99%

Protection from injury of organs adjacent to a renal tumor during percutaneous cryoablation

et al. 2019

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Renal cryoablation has become accepted as treatment for small renal tumors as an alternative to surgery. However, parallel with the increase in the use of this therapy, there also has been increases in the number of reports of complications related to renal cryoablation. One potential complication is injury to important non-renal structures adjacent to the ablated renal tumor, such as the colon, duodenum, ureter, psoas muscle and so on. To prevent injury of adjacent organs, separating organs from the tumor is desirable. Over the past 15 years, several techniques have been developed to protect against injury of organs adjacent to renal tumors that are targets of cryoablation. The most commonly used technique for this purpose has been hydrodissection. Others include dissection with gas, balloon dissection and probe traction. To avoid injury of a ureter running near the renal tumor, pyeloperfusion is known to be useful. The rate of cases necessitating avoidance of organ injury by using these techniques is relatively high. In some cases, more than two techniques are combined. In the present review, we provided an overview of techniques currently available to protect against organ injuries, and discussed the advantages and disadvantages of each technique.

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Locoregional Therapy: Cancer Interventions with and Without Radionuclides

Yevich

Mahvash

2020

Locoregional Radionuclide Cancer Therapy

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Radiofrequency ablation versus cryoablation for T1b renal cell carcinoma: a multi-center study

Abstract: Other than primary technique efficacy, the clinical outcomes between RFA and cryoablation were similar in patients with cT1b RCC.

Cited by 44 publications

References 35 publications

Computed tomography-guided percutaneous cryoablation of T1b renal tumors: safety, functional and oncological outcomes

Computed tomography-guided percutaneous cryoablation of T1b renal tumors: safety, functional and oncological outcomes

Protection from injury of organs adjacent to a renal tumor during percutaneous cryoablation

Locoregional Therapy: Cancer Interventions with and Without Radionuclides

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