Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract in patients with left ventricular dilation and/or dysfunction

Premature ventricular complexes (PVC)-induced cardiomyopathy: A review and meta-analysis of pathophysiology, diagnosis and clinical management

“…The weighted mean difference (WMD) was -22.31% (95% CI: -23.93 to -20.69; p = 0.000) Figure 1. In eight studies [19][20][21]48,[57][58][59]61], the drop in PVC-burden corresponded with a decrease in LVEF baseline (52.24%; 95% CI: 51.54-52.95) to post-RFA (63.19%; 95% CI: 62.46-63.92). The WMD between post-RFA and baseline LVEF was significant (WMD: 10.33%; 95% CI: 5.57 to 15.08; p = 0.000; Figure 2).…”

“…Study characteristics: The electronic search yielded 201 studies. Of the 201, only 11 studies that met the inclusion criteria formed the final dataset for analysis [19][20][21]45,48,[56][57][58][59][60][61]. These studies are relatively recent, published between 2005 [21] and 2018 [61].…”

“…These studies are relatively recent, published between 2005 [21] and 2018 [61]. Except one prospective study [58], the remaining 10 studies adopted a retrospective design [19][20][21]45,48,56,57,[59][60][61]. Two studies [20,21] grouped patients based on PVC burden; three other studies [58,60,61] grouped patients into two -those with and those without structural heart diseases, while the remaining six studies compared PICM patients with LV dysfunction) and control (those with PVC but without LV dysfunction) [19,45,48,56,57,59].…”

“…Except one prospective study [58], the remaining 10 studies adopted a retrospective design [19][20][21]45,48,56,57,[59][60][61]. Two studies [20,21] grouped patients based on PVC burden; three other studies [58,60,61] grouped patients into two -those with and those without structural heart diseases, while the remaining six studies compared PICM patients with LV dysfunction) and control (those with PVC but without LV dysfunction) [19,45,48,56,57,59]. The different objectives of the 11 studies can be subsumed under just two broad objectives: (i) to assess eth efficacy of ablation therapy on LV dysfunction and PVC burden; and (ii) to determine the predictors of PICM on patients with frequent PVCs.…”

“…The primary treatment for PICM in the 11 studies was radiofrequency ablation (RFA) for PVC that were refractory to medical therapy. Pooled analysis of data from five studies [19,48,57,59,61] revealed RFA therapy led to a significant reduction in the PVC burden from the baseline value of 26.09% (95% CI: 24.69-27.50) to post-RFA value of 0.89% (95% CI: 0.72 to 1.07). The weighted mean difference (WMD) was -22.31% (95% CI: -23.93 to -20.69; p = 0.000) Figure 1.…”