Radiofrequency Microneedling: A Comprehensive and Critical Review

Tan, Marcus G.; Jo, Christine E.; Chapas, Anne; Khetarpal, Shilpi; Dover, Jeffrey S.

doi:10.1097/dss.0000000000002972

Cited by 54 publications

(51 citation statements)

References 46 publications

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“…[8][9][10] For acne scars, most of the patients show mild to moderate (25%-50%) improvement. [9][10][11] Fractional radiofrequency microneedling can be used in combination therapy with other lasers such as FNAL or FAL. Within acne scar subtypes, it is most effective in boxcar and rolling scars and least effective in icepick scars.…”

Section: Discussionmentioning

confidence: 99%

Review of Lasers and Energy-Based Devices for Skin Rejuvenation and Scar Treatment With Histologic Correlations

et al. 2022

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BACKGROUND Lasers and energy-based devices (EBD) are popular treatments for skin rejuvenation and resurfacing. Achieving desired outcomes and avoiding complications require understanding the effects of these devices at a histologic level. Currently, no comprehensive review summarizing the histologic effects of laser and energy-based treatments exists. OBJECTIVE To describe how lasers and EBD alter skin histology and improve the overall understanding of these devices. MATERIALS AND METHODS A PubMed search was conducted for studies with histologic analysis of fractional picosecond laser, fractional radiofrequency microneedling, nonablative lasers, and ablative lasers. RESULTS Fractional picosecond lasers induce intraepidermal and/or dermal vacuoles from laser-induced optical breakdown. Fractional radiofrequency microneedling delivers thermal energy to the dermis while sparing the epidermis, making it safer for patients with darker skin phototypes. Fractional nonablative lasers induce conical zones of coagulation of the epidermis and upper dermis. Ablative lasers vaporize the stratum corneum down to the dermis. Traditional ablative lasers cause diffuse vaporization while fractional ablative lasers generate columns of tissue ablation. CONCLUSION Lasers and EBD are effective for skin resurfacing and rejuvenation and have different mechanisms with disparate targets in the skin. Safe and effective use of devices requires understanding the histologic laser-tissue interaction.

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Section: Discussionmentioning

confidence: 99%

Review of Lasers and Energy-Based Devices for Skin Rejuvenation and Scar Treatment With Histologic Correlations

et al. 2022

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“…One is RFMN, a system that uses microneedles. The benefits of RFMN include the delivery of uniform heat to dermal layers at controlled depth using microneedles with protection of the skin surface [ 18 – 20 ]. Our previous study found that the thermal response to RFMN treatment induced a wound healing cascade leading to long-term dermal remodeling.…”

Section: Discussionmentioning

confidence: 99%

“…Although the effects of RFMN are slow and progressive, the procedure can be used repeatedly and safely in combination with other treatment modalities to augment its efficacy [ 20 ]. Recently, various wound healing accelerators, such as polynucleotides (PNs), stem cell culture media, and platelet-rich plasma, have received attention in wound and scar management.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Using Noninsulated Microneedle Radiofrequency Alone versus in Combination with Polynucleotides for Treatment of Periorbital Wrinkles

Yogya

Wanitphakdeedecha

Wongdama

et al. 2022

Dermatol Ther (Heidelb)

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Introduction A few studies have evaluated the efficacy and safety of noninsulated radiofrequency microneedling (RFMN) to treat periorbital wrinkles in Asian patients. Recently, wound healing accelerators, polynucleotides (PNs), have received attention in wound management. However, their efficacy and safety have not been fully elucidated following RFNM. This study aimed to evaluate the efficacy and safety of noninsulated RFMN for periorbital wrinkles and the synergistic effect of PNs after RFMN. Methods Thirty subjects with Fitzpatrick skin types III to V and facial wrinkles (Fitzpatrick grades I and II) were enrolled. All volunteers were treated over the entire face with noninsulated RFMN for three sessions at 2-week intervals. The left and right sides of each patient’s face were randomly assigned to receive PNs (treatment group) or normal saline solution (control group). The indentation and maximum depth of wrinkles were objectively measured using Antera 3D. Subjective self-evaluations were obtained at baseline, 2 weeks after the third treatment, and at 1, 2, 3, and 6 months after the final treatment. In addition, pain scores, immediate reactions, and other adverse effects were evaluated. Results Twenty-nine subjects completed the treatment protocol. Most presented with grade II wrinkling (69%). At 2-month follow-up, Antera 3D image analysis revealed faster improvement for the treatment group. At 6-month follow-up, the majority of subjects reported an improvement of 25–75% in their periorbital wrinkles. The average pain score was 2.2 out of 10. No serious adverse events (infection, pigmentary alteration, persistent erythema, or scarring) were observed. Conclusions Noninsulated RFMN is safe and effective for treating periorbital wrinkles and can be used as a modality for transdermal drug delivery. Topical polynucleotides as an adjunctive treatment provide additional benefits for periorbital wrinkle treatment. Trial Registration Number TCTR20201105007.

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“…12 Based on the quality of clinical studies, it is strongly recommended for acne scars and acne vulgaris, especially for patients with a darker skin phototypes. 12 Microneedling can also be combined with microdermabrasion, LED light, or other dermatological treatment systems with the goal of additive benefits, however, little research has been done on the efficacy of these combination treatments. 5,6 Microneedling devices should be sterilized with alcohol before and after every use as insufficient cleaning may increase the risk of infection or injury.…”

Section: T Ype S Of MI Croneedle Smentioning

confidence: 99%

Microneedling for Hair Loss

Gupta

Quinlan

Venkataraman

et al. 2021

J of Cosmetic Dermatology

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Background: Microneedling is a relatively novel therapeutic modality introduced in the 1990s where small, fine needles are used to create micro punctures in the skin. It is a minimally invasive procedure used for various dermatological conditions, including androgenetic alopecia (AGA). Objective and Methods:We comprehensively summarize the literature regarding microneedling in dermatology. We performed linear multivariable regressions to synthesize evidence from the clinical trials that investigated the efficacy of microneedling for AGA. Studies eligible for quantitative analyses were assessed for evidence quality. Results:The exact mechanism of microneedling action is yet to be determined, with theories that include the wound-healing cascade. Microneedling monotherapy significantly increased total hair count more than topical minoxidil 5% (β = 12.29; p < 0.001).The combination treatment of microneedling with topical 5% minoxidil increased total hair count significantly compared to monotherapy with microneedling (β = 7.63, p < 0.05). Increasing the overall treatment duration of microneedling and reducing the frequency of microneedling sessions may positively influence an increase in total hair count. Conclusion:There are limited studies that investigate microneedling as a monotherapy for hair loss since majority of the trials combine it with other therapies such as topical minoxidil or platelet-rich plasma. While preliminary results look promising, further investigation of microneedling as a monotherapy in larger, randomized controlled trials will help determine its safety and efficacy, and place in treating AGA.

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Radiofrequency Microneedling: A Comprehensive and Critical Review

Cited by 54 publications

References 46 publications

Review of Lasers and Energy-Based Devices for Skin Rejuvenation and Scar Treatment With Histologic Correlations

Review of Lasers and Energy-Based Devices for Skin Rejuvenation and Scar Treatment With Histologic Correlations

Efficacy and Safety of Using Noninsulated Microneedle Radiofrequency Alone versus in Combination with Polynucleotides for Treatment of Periorbital Wrinkles

Microneedling for Hair Loss

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