Radiogenomic Analysis of Breast Cancer: Luminal B Molecular Subtype Is Associated with Enhancement Dynamics at MR Imaging

Abstract

The luminal B subtype of breast cancer is associated with MR imaging features that relate the enhancement dynamics of the tumor and the background parenchyma.

Evaluation of background parenchymal enhancement on breast MRI: a systematic review

“…7,57,60 Tagliafico et al 7 assessed BPE using fully automated software that performed an objective and reproducible voxel-by-voxel analysis. This software used an algorithm based on the maximum entropy method and a threshold value.…”

“…7 Mazurowski et al 57 used computer vision algorithms that extracted all the features automatically, including a dynamic feature of the background parenchyma. 57 Wu et al 60 used a validated fully automated method that allowed segmentation and quantitative measure of fibroglandular tissues and BPE. 60 Qualitative and quantitative background parenchymal enhancement assessment Among the 11 studies that assessed BPE in both qualitative and quantitative methods, 7,20,22,24,29,30,32,34,35,46,47 27% (3/11) studies were published in 2015 (January-October 2015) and 73% (8/11) studies were published during 2010-2014.…”

“…8,10,[12][13][14][15]21,23,26,28,[32][33][34][35][36]38,[40][41][42][43][48][49][50][51][52][53][54]57,59,61 In five studies, 11,17,19,29,44 the authors acknowledged that owing to the retrospective nature of the study, it was not possible to analyze the point of menstrual cycle, although, following institutional protocol, screening breast MRI of patients who were pre-menopausal was performed during the second week of the menstrual cycle. In a total of 14 studies, the authors stated the menstrual period.…”

Imaging genomics in cancer research: limitations and promises

“…All studies were retrospective in design. Five studies used data from TCGA/ TCIA; 45,46,48,49,57 one study used multi-institutional data; 50 and one study combined both institutional data and data from TCGA/TCIA. 44 The number of patients ranged from 25 to 539 with a median of 75.…”

“…11 (29%) studies used semiautomatic image feature extraction. 45 28,47,48,50,51,55,57,59,61,63,[69][70][71]79 Only four studies correlated with histology. 50,60,71,74 None of the study verified their results via wet-lab techniques.…”