Radiographic evaluation of non-localizing parathyroid adenomas

Payne, Sakeena J.; Smucker, Joanne; Bruno, Michael A.; Winner, Louis; Saunders, Brian; Goldenberg, David

doi:10.1016/j.amjoto.2014.10.036

Cited by 8 publications

(10 citation statements)

References 19 publications

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“…9 The study by Carpentier et al demonstrated that radionucleotide retention in 99m Tc sestamibi scans is related to oxyphil cell content and a pathologic study by Mihai et al showed a higher proportion of chief cells in the glands of patients with nonlocalizing scans. Payne et al demonstrated that nonlocalization on 99m Tc sestamibi is not due to inaccurate interpretation of imaging and several studies have suggested biological a basis for negative imaging.…”

Section: Discussionmentioning

confidence: 99%

“…Payne et al demonstrated that nonlocalization on 99m Tc sestamibi is not due to inaccurate interpretation of imaging and several studies have suggested biological a basis for negative imaging. 9 The study by Carpentier et al demonstrated that radionucleotide retention in 99m Tc sestamibi scans is related to oxyphil cell content and a pathologic study by Mihai et al showed a higher proportion of chief cells in the glands of patients with nonlocalizing scans. 10,11 Negative studies have been also associated with ectopic parathyroid glands, smaller gland size, and an increased incidence of MGD.…”

Section: Discussionmentioning

confidence: 99%

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Outcomes of parathyroidectomy for primary hyperparathyroidism with nonlocalizing preoperative imaging

et al. 2018

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Background The purpose of this study was to evaluate our surgical experience in patients with primary hyperparathyroidism (PHPT) with nonlocalizing sestimibi and ultrasound scans. Methods A retrospective review of 521 patients treated from April 2005 to July 2017 at Loma Linda University Medical Center who received parathyroidectomy for PHPT. One hundred forty‐seven patients (28%) had double negative localization (nonlocalizing sestamibi and ultrasound). Results Surgical cure for PHPT was 97.3% and 99.2% with nonlocalized and localized disease, respectively, and complication rates were similar between groups. Preoperative parathyroid hormone and gland weight were significantly lower with nonlocalization. The incidence of multigland disease (MGD) was greater in patients with nonlocalization on sestamibi and ultrasound. Conclusion Nonlocalization of parathyroid glands was not associated with decreased cure rate or increased morbidity. The presence of MGD and requirement for more extensive surgery were greater in patients with nonlocalizing disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Outcomes of parathyroidectomy for primary hyperparathyroidism with nonlocalizing preoperative imaging

et al. 2018

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“…A subset of parathyroid adenomas fail to localize on imaging with both ultrasound and sestamibi scintigraphy . The diagnostic performance of 4D‐CT has been found superior to other modalities, but also has higher relative cost and radiation exposure.…”

Section: Parathyroid Imaging In Context: Relative Value As It Relatesmentioning

confidence: 99%

American Head and Neck Society Endocrine Surgery Section update on parathyroid imaging for surgical candidates with primary hyperparathyroidism

Zafereo

Angelos

et al. 2019

Head & Neck

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Health care consumer organizations and insurance companies increasingly are scrutinizing value when considering reimbursement policies for medical interventions. Recently, members of several American Academy of Otolaryngology-Head & Neck Surgery (AAO-HNS) committees worked closely with one insurance company to refine reimbursement policies for preoperative localization imaging in patients undergoing surgery for primary hyperparathyroidism. This endeavor led to an AAO-HNS parathyroid imaging consensus statement (https://www.entnet.org/ content/parathyroid-imaging). The American Head and Neck Society Endocrine Surgery Section gathered an expert panel of authors to delineate imaging options

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“…5 However, despite sound radiographic technique, a subset of parathyroid adenomas cannot be localized by ultrasound or sestamibi scanning. 6 …”

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confidence: 99%

Parathyroid Localization Using 4D-Computed Tomography

et al. 2015

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Radiographic evaluation of non-localizing parathyroid adenomas

Cited by 8 publications

References 19 publications

Outcomes of parathyroidectomy for primary hyperparathyroidism with nonlocalizing preoperative imaging

Outcomes of parathyroidectomy for primary hyperparathyroidism with nonlocalizing preoperative imaging

American Head and Neck Society Endocrine Surgery Section update on parathyroid imaging for surgical candidates with primary hyperparathyroidism

Parathyroid Localization Using 4D-Computed Tomography

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