Radiographic evidence of mandibular osteoporosis improvement in Wistar rats treated with Ginkgo biloba

Abstract

The EGb recovered the periodontal bone support and increased the mandibular cortical thickness. The EGb may be effective in the treatment of osteoporosis.

The Effect of the Ginkgo biloba Extract in the Expression of Bax, Bcl‐2 and Bone Mineral Content of Wistar Rats with Glucocorticoid‐Induced Osteoporosis

“…Recently, studies of G. biloba in osteoporosis and bone metabolism have shown promising results stimulating osteoblast differentiation (Brayboy et al , ; Oh et al , ). Also, Trivedi et al () reported that EGb improved bone mineral density in ovariectomized rats, in the same way that in our previous studies EGb improved periodontal bone support and the percentage of alveolar bone support in the mandible and trabecular bone in femur of rats with GIO (Lucinda et al , ,).…”

“…G. biloba is a plant that is currently being used by the population for its therapeutic properties; however, very little is known about its effects in osteoporosis because of the lack of preclinical and absence of clinical studies. The preclinical studies suggest that EGb is a promising therapy to recover bone loss in estrogen depletion osteoporosis (Trivedi et al , ; Oh et al , ) and in the GIO (Lucinda et al , , ).…”

“…The osteoporosis induction was done through the intramuscular administration of dexamethasone disodium phosphate (Decadron® 4 mg/mL) at the dose level of 7 mg/kg of body weight, once a week, during 5 weeks in all groups, except in the control group (Lucinda et al , ,).…”

“…The alendronate, EGb1 and EGb2 groups were treated intragastrically, once a day, during 20 days ( n = 30) and 30 days ( n = 30), after the osteoporosis induction. The choice of EGb doses was based on previous studies (Lucinda et al , ,).…”

Therapeutic Effects of Alpha Lipoic Acid and Vitamin C on Alveolar Bone Resorption After Experimental Periodontitis in Rats: A Biochemical, Histochemical, and Stereologic Study

“…Computer‐aided design program ‖‖‖ measurements were calibrated by the standard lead bar length on the radiograph. Three points on the radiographs were considered as shown in Figure 2, that is, the apex of the distal/mesial root (A), the crest bone on the distal/mesial surface of the tooth (B), and the tip of the distal/mesial cusp (C) according to the method described by Lucinda et al 30 The linear distances between AB and AC points were measured to calculate the periodontal bone support near the root using the following mathematical formula: AB/AC × 100 31 …”