Radiographic manifestations of transfusion-related acute lung injury

Carcano, Carolina; Okafor, Ndubuisi; Martinez, Felipe; Ramírez, José; Kanne, Jeffrey P.; Kirsch, Jacobo

doi:10.1016/j.clinimag.2013.06.008

Cited by 23 publications

(16 citation statements)

References 15 publications

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“…20,40 Noninfectious complications secondary to treatment In the 6 h following the transfusion of blood products, the sudden appearance of consolidations simulating an edema and accompanying a respiratory failure usually reflect acute pulmonary damage (APD) called TRALI (transfusion-related alveolar lung injury) which associates high mortality rates. 41 Any courses of chemotherapy can cause pulmonary toxicity, although the most usual patterns are: organizing pneumonia (OP), unspecific interstitial pneumonia (UIP), pneumonitis due to hypersensitivity, eosinophilic pneumonia and diffuse alveolar damage. Carmustine (used in lymphomas and MM), which usually gives a UIP pattern 42 ; cytarabine (administered in high doses for the treatment of AML), that can cause non-cardiogenic pulmonary edema 43 and bleomycin (lymphoma treatment), causing diffuse alveolar damage and OP are among the most common drugs used.…”

Section: Disease Noninfectious Complicationsmentioning

confidence: 99%

Hematologic neoplasms: Interpreting lung findings in chest computed tomography

Batlles

Polo

Sanz

et al. 2015

Radiología (English Edition)

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Lung disease is very common in patients with hematologic neoplasms and varies in function of the underlying disease and its treatment. Lung involvement is associated with high morbidity and mortality, so it requires early appropriate treatment. Chest computed tomography (CT) and the analysis of biologic specimens are the first line diagnostic tools in these patients, and sometimes invasive methods are necessary. Interpreting the images requires an analysis of the clinical context, which is often complex. Starting from the knowledge about the differential diagnosis of lung findings that radiologists acquire during training, this article aims to explain the key clinical and radiological aspects that make it possible to orient the diagnosis correctly and to understand the current role of CT in the treatment strategy for this group of patients. Neoplasias hematológicas; Trasplante de precursores hematopoyéticos; Neoplasias hematológicas: interpretación de los hallazgos pulmonares en la tomografía computarizada torácicaResumen La patología pulmonar en la historia de un paciente con neoplasia hematológica es muy frecuente y variable en función de la enfermedad de base y la terapia recibida. La morbimortalidad asociada es alta, por lo que requiere un tratamiento correcto y precoz. La tomografía computarizada (TC) torácica, junto con el análisis de muestras biológicas, son las ଝ Please cite this article as: Calvillo Batllés P, Carreres Polo J, Sanz Caballer J, Salavert Lletí M, Compte Torrero L. Neoplasias hematológicas: interpretación de los hallazgos pulmonares en la tomografía computarizada torácica. Radiología. 2015;57:455---470. P. Calvillo Batllés et al.Tomografía computarizada multidetector; Enfermedad pulmonar herramientas de diagnóstico de primera línea empleadas en estos pacientes, y en determinados casos se requieren métodos invasivos. La interpretación de las imágenes exige el análisis de un contexto clínico en muchas ocasiones complejo. Partiendo del conocimiento que adquiere el radiólogo en su formación sobre el diagnóstico diferencial de los hallazgos pulmonares, el objetivo de este trabajo es explicar los aspectos clínicos y radiológicos claves que permiten orientar correctamente el diagnóstico y asimilar el papel actual de la TC en la estrategia terapéutica de este grupo de enfermos.

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Section: Disease Noninfectious Complicationsmentioning

confidence: 99%

Hematologic neoplasms: Interpreting lung findings in chest computed tomography

Batlles

Polo

Sanz

et al. 2015

Radiología (English Edition)

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“…Por otro lado, el EPA se define como una acumulación anormal de líquido en los compartimentos extravasculares del pulmón 6 , cuya etiología igualmente responde a múltiples patologías.…”

Section: Discussionunclassified

Lesión pulmonar aguda asociada a transfusión (TRA LI): reporte de un caso clínico

Castro¹,

Carrasco²,

Carraha³

2024

RCHRAD

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La lesión pulmonar aguda asociada a transfusión (TRALI, transfusion-associated acute pulmonary injury) es una patología poco común, definida como un síndrome de distrés respiratorio agudo caracterizado por insuficiencia respiratoria aguda y edema pulmonar agudo que se manifiesta en el periodo comprendido dentro de las 6 horas posteriores a una transfusión. Se presenta el caso de una paciente joven con diagnóstico de TRALI, quien previamente fue sometida a una cirugía electiva que requirió una transfusión. Además, se realiza una breve revisión de la literatura sobre el tema.

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“…Thoracic radiographs may help eliminate non‐transfusion‐related causes of respiratory disease including aspiration pneumonia, metastatic pulmonary disease, pulmonary thromboembolic disease. Animals with transfusion‐associated circulatory overload (TACO) or transfusion‐related acute lung injury (TRALI) generally have diffuse bilateral pulmonary infiltrates (TACO and TRALI), and patients with TACO may have cardiomegaly, enlarged pulmonary venous vasculature, or pleural effusion on thoracic radiographs 11,12 . However, it is important to note that radiographic changes are non‐specific for both TRALI and TACO 12 .…”

Section: Domain 3: Diagnosismentioning

confidence: 99%

Association of Veterinary Hematology and Transfusion Medicine (AVHTM) transfusion reaction small animal consensus statement (TRACS). Part 3: Diagnosis and treatment

Odunayo

Nash²,

Davidow

et al. 2021

J Vet Emergen Crit Care

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Objective To systematically review available evidence to develop guidelines for diagnosis and treatment of transfusion‐associated reactions in dogs and cats. Design Standardized and systemic evaluation of the literature (identified through Medline via PubMed and Google Scholar searches) was carried out for identified transfusion reaction types in dogs and cats. The available evidence was evaluated using PICO (Population, Intervention, Comparison, Outcome) questions generated for each reaction type. The evidence was categorized by level of evidence (LOE) and quality (Good, Fair, or Poor). Guidelines, diagnostic, and treatment algorithms were generated based on the evaluation of the evidence. Consensus on the final guidelines was achieved through Delphi‐style surveys. Draft recommendations were disseminated through veterinary specialty listservs for review and comments, which were evaluated and integrated prior to final publication. Results Medline via PubMed and Google Scholar databases were searched. There were 14 Population Intervention Comparison Outcome questions identified and corresponding worksheets were developed focusing on the diagnosis and treatment of transfusion‐associated reactions in dogs and cats. Fourteen guidelines and four algorithms were developed with a high degree of consensus. Conclusions This systematic evidence evaluation process yielded recommended diagnostic and treatment algorithms for use in practice. However, significant knowledge gaps were identified, demonstrating the need for additional research in veterinary transfusion medicine.

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Radiographic manifestations of transfusion-related acute lung injury

Cited by 23 publications

References 15 publications

Hematologic neoplasms: Interpreting lung findings in chest computed tomography

Hematologic neoplasms: Interpreting lung findings in chest computed tomography

Lesión pulmonar aguda asociada a transfusión (TRA LI): reporte de un caso clínico

Association of Veterinary Hematology and Transfusion Medicine (AVHTM) transfusion reaction small animal consensus statement (TRACS). Part 3: Diagnosis and treatment

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