Radioimmunoimaging of Non-Small Cell Lung Cancer with¹¹¹In- and^99MTc-Labeled Monoclonal Anti-Cea-Antibodies

Anti-CEA immunoscintigraphy and computed tomographic scanning in the preoperative evaluation of mediastinal lymph nodes in lung cancer.

“…-46-10 1214-17 Less information is available, however, concerning the staging potential of this technique.8101214-17 Excluding the data shown in the current report, all available information is restricted to about 100 patients and is limited by the inhomogeneity of studies.8 [14][15][16][17] For example, different commercially available immunoreagents (including the F(ab')2 fragments of the F6 antibody,'5 the F(ab')2 fragments of BW431/3 ,14 and the intact BW43 1/268 14 15) have been used and labelled to different radionuclides (indiumll 14 16 technetium-99,81415 and iodine-i 3117). Furthermore, the clinical target has varied in the different studies up to the extreme in the study of MacMillan et al15 who only considered patients with small cell lung cancer, and no separate analysis has been made for lymphatic spread and direct invasion of mediastinum.8 1415 Above all, SPECT images were not always obtained.8 1415 This has caused inconsistent results with sensitivities in the range 40-75% and specificities in the range of 33-81%.8 14-17 Because of these inconsistencies we believe that the results of our study on the value of anti-CEA immunoscintigraphy in the preoperative mediastinal assessment are important.…”

Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen

“…99m Tc has been used to label many anti-CEA antibodies (e.g. BW431/26, IMMU-4 and 88BV59) and used in clinical studies for the detection of colorectal, breast and lung cancer (Barzen et al 1992; Baum et al 1989; Behr et al 1995; Fraile et al 1991; Gonzalez et al 1991; Kairemo et al 1993; Lacic et al 1999; Lind et al 1989; Lind et al 1991a; Lind et al 1991b; Oriuchi et al 1995; Patt et al 1994; Serafini et al 1998; Sirisriro et al 1996; Stomper et al 1995; Takenoshita et al 1995). It was concluded that 99m Tc-based immunoSPECT is a suitable method for cancer diagnosis, especially for recurrences.…”

Anti-CEA immunoscintigraphy and computed tomographic scanning in the preoperative evaluation of mediastinal lymph nodes in lung cancer

“…Several studies have evaluated anti-CEA immunoscintigraphy in the diagnosis of lung cancer. -46-10 1214-17 Less information is available, however, concerning the staging potential of this technique.8101214-17 Excluding the data shown in the current report, all available information is restricted to about 100 patients and is limited by the inhomogeneity of studies.8 14-17 For example, different commercially available immunoreagents (including the F(ab')2 fragments of the F6 antibody,'5 the F(ab')2 fragments of BW431/3 ,14 and the intact BW43 1/268 14 14 16 technetium-99,81415 and iodine-i 3117).…”

“…In patients with lung cancer several studies have shown that immunoscintigraphy may detect the primary tumour and the possible presence of regional and distant metastases. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] In 13 of 17 clinical investigations so far available for evaluation, tumour targeting was attempted with anti-carcinoembryonic antigen (CEA) antibodies 2-46-101214-17 and anti-CEA immunoscintigraphy can be regarded as the standard for immunoscintigraphic diagnosis. In a recent review of studies of anti-CEA immunoscintigraphy in lung cancer'9 the average detection rates for primary, mediastinal, and distant tumour metastases were 87% (216 of 248 patients), 70% (49 of 70), and 84% (109 of 130), respectively.…”