Radioiodine Avid Axillary Lymph Node Metastasis in Papillary Thyroid Cancer: Report of a Case

Damle, Nishikant; Singh, Harmandeep; Soundararajan, Ramya; Bal, Chandrasekhar; Sahoo, Manoranjan; Mathur, Sandeep

doi:10.1007/s13193-011-0093-3

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…The sodium iodine symporter (NIS) protein is specifically expressed in the thyroid cells, and mediates thyroidal I–transport from the bloodstream to the colloid [ 12 , 13 , 14 ]. All-trans retinoic acid (ATRA) regulates NIS expression [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis

Mei

Chen

et al. 2017

PLoS ONE

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Recently, diagnoses of radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) have become more common; prognosis is poor. It has been suggested that cancer stem cells account for radiotherapy resistance. By flow cytometry, different expression percents of CD133 and OCT4 in thyroid cancer cell lines were detected. By real-time quantitative PCR, different mRNA expression of CD133, OCT4, GLUT1, thyroglobulin (TG), thyroperoxidase (TPO) and sodium iodine symporter (NIS) was analyzed; the localization of CD133, OCT4, and NIS expression was examined using immunofluorescence confocal microscopy. Different expression of CD133, OCT4, and NIS in 21 human thyroid cancer and nodule tissues was investigated using immunohistochemistry. CD133-positive cells were isolated by magnetic sorting. Stronger colony formation ability of CD133-positive and weaker ability of CD133-negative cells in vivo were examined by colony formation. The effects of all-trans retinoic acid (ATRA) on CD133-positive cells in vivo were explored with Cell Counting Kit-8, colony formation, apoptosis, cell cycle, and ethynyl deoxyuridine assays. The ARO cell line and RAI-R DTC tissue specimens had more CD133-positive cells. NIS expression was significantly lower in RAI-R DTC tissue compared to radioiodine-sensitive DTC (RAI-DTC) tissue and specimens from patients with thyroid nodule. ATRA inhibited the stem cell characteristics of CD133-positive cells and induced CD133-positive cell differentiation to CD133-negative cells, and promoted CD133-positive cell apoptosis.

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Section: Introductionmentioning

confidence: 99%

All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis

Mei

Chen

et al. 2017

PLoS ONE

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“…Axillary lymph node metastasis is known to be associated with systemic disease and a poor prognosis. Aggressive management of such cases is required such as metastatic axillary lymphadenectomy and/or 131 I therapy in cases which are radioiodine avid and have concomitant distant metastasis [10]. This case highlights the importance for long-term follow-up of patients with Hürthle cell carcinoma of thyroid.…”

Section: Discussionmentioning

confidence: 92%

Detection of Solitary Axillary Lymph Node Metastases from Hürthle Cell Carcinoma of the Thyroid on 18F-FDG PET/CT

Prabhu

Jain

Gupta

et al. 2018

Nucl Med Mol Imaging

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Thyroid carcinoma is the most common neoplasm of endocrine malignancies. Differentiated thyroid carcinoma (DTC) constitutes 90% of the thyroid carcinomas, rest being medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC). Distant metastases occur in up to 10% of patients with DTC. Metastases to axillary lymph nodes (ALN) are very rare. As per literature, only 25 cases have been reported. We report an unusual case of 47-year-old male with Hürthle cell carcinoma of the thyroid presenting with a solitary axillary lymph node metastasis 17 years after thyroidectomy, along with review of literature.

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“…which detected axillary nodal recurrence in follow-up evaluation using SPECT/CT. [ 10 ] However, to the best of the authorsâ€™ knowledge, no report has yet detailed the axillary metastases from classic type of papillary carcinoma as initial presentation detected using SPECT/CT. There was another report that describes Axillary lymph node metastasis of papillary thyroid carcinoma detected by fluorodeoxyglucose PET/CT in a thyroglobulin-positive patient with negative whole-body 131 I scan.…”

Section: Discussionmentioning

confidence: 99%

Rare case of axillary lymph node metastasis in papillary thyroid carcinoma detected using Iodine-131 whole-body scintigraphy and single-photon emission computed tomography/computed tomography

et al. 2015

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Differentiated thyroid cancer is, usually, associated with an excellent prognosis and indolent course. Distant metastases are rare events at the onset of thyroid cancer. Among these presentations, metastasis to the axillary lymph nodes is even more unusual. Only few cases of papillary carcinoma with axillary nodal metastasis were previously reported in the literature. We present a 38-year-old female who underwent Iodine-131 whole-body scintigraphy, after total thyroidectomy and bilateral neck lymph node dissection for papillary carcinoma of thyroid, showed intense uptake in the remnant thyroid, lung metastasis, left cervical and left axillary lymph nodes. Excision of left axillary lymph nodes confirmed metastatic papillary carcinoma.

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Radioiodine Avid Axillary Lymph Node Metastasis in Papillary Thyroid Cancer: Report of a Case

Cited by 6 publications

References 14 publications

All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis

All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis

Detection of Solitary Axillary Lymph Node Metastases from Hürthle Cell Carcinoma of the Thyroid on 18F-FDG PET/CT

Rare case of axillary lymph node metastasis in papillary thyroid carcinoma detected using Iodine-131 whole-body scintigraphy and single-photon emission computed tomography/computed tomography

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