Radioisotopes and Their Biomedical Applications

Khan, Nida Tabassum

doi:10.4172/2167-7956.1000156

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…The radioisotope labeled in a molecule emits energy in the form of radiation, and thus monitoring of radiation decay makes it possible to trace the molecule of interest in biological systems. The use of a well-established radioanalytical technique and an appropriate radiotracer enables the straightforward, accurate, and sensitive detection of target molecules in biological tissues and living subjects [ 9 , 10 ]. Among several types of radioactive decay, gamma (γ) rays are highly penetrating, and they do not interfere with the analytical signal.…”

Section: Introductionmentioning

confidence: 99%

Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances

et al. 2020

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Concern about environmental exposure to hazardous substances has grown over the past several decades, because these substances have adverse effects on human health. Methods used to monitor the biological uptake of hazardous substances and their spatiotemporal behavior in vivo must be accurate and reliable. Recent advances in radiolabeling chemistry and radioanalytical methodologies have facilitated the quantitative analysis of toxic substances, and whole-body imaging can be achieved using nuclear imaging instruments. Herein, we review recent literature on the radioanalytical methods used to study the biological distribution, changes in the uptake and accumulation of hazardous substances, including industrial chemicals, nanomaterials, and microorganisms. We begin with an overview of the radioisotopes used to prepare radiotracers for in vivo experiments. We then summarize the results of molecular imaging studies involving radiolabeled toxins and their quantitative assessment. We conclude the review with perspectives on the use of radioanalytical methods for future environmental research.

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Section: Introductionmentioning

confidence: 99%

Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances

et al. 2020

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Production of ⁶⁸Ge, ⁶⁸Ga, ⁶⁷Ga, ⁶⁵Zn, and ⁶⁴Cu important radionuclides for medical applications: theoretical model predictions for α-particles with ⁶⁶Zn at ≈10–40 MeV

Amanuel

2022

Radiochimica Acta

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Theoretical predictions were made using TALYS-1.95(G) and EMPIRE 3.2 reaction-model codes for 69Ge, 67Ge, and medically used 68Ge, 67Ga, 68Ga, 65Zn, 64Cu radionuclides produced in the interaction of α-projectile with 66Zn-target at 10–40 MeV α-energies. Pearson’s statistical coefficients showed moderate to strong positive correlations between the theoretically predicted and experimentally measured production cross sections for radionuclides with practical medical applications. Furthermore, the present results indicated that a medium-sized cyclotron and a single α + 66Zn system (projectile + target system) might be an option for optimized production of 68Ge, 68Ga, 67Ga, 65Zn, and 64Cu radionuclides.

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Radioisotopes and Their Biomedical Applications

Cited by 2 publications

References 3 publications

Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances

Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances

Production of ⁶⁸Ge, ⁶⁸Ga, ⁶⁷Ga, ⁶⁵Zn, and ⁶⁴Cu important radionuclides for medical applications: theoretical model predictions for α-particles with ⁶⁶Zn at ≈10–40 MeV

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Radioisotopes and Their Biomedical Applications

Cited by 2 publications

References 3 publications

Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances

Radioanalytical Techniques to Quantitatively Assess the Biological Uptake and In Vivo Behavior of Hazardous Substances

Production of 68Ge, 68Ga, 67Ga, 65Zn, and 64Cu important radionuclides for medical applications: theoretical model predictions for α-particles with 66Zn at ≈10–40 MeV

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Production of ⁶⁸Ge, ⁶⁸Ga, ⁶⁷Ga, ⁶⁵Zn, and ⁶⁴Cu important radionuclides for medical applications: theoretical model predictions for α-particles with ⁶⁶Zn at ≈10–40 MeV