Radiolabeled WBC Scintigraphy in the Diagnostic Workup of Patients With Suspected Device-Related Infections

Erba, Paola Anna; Sollini, Martina; Conti, Umberto; Bandera, Francesco; Tascini, Carlo; Tommasi, Sara; Zucchelli, Giulio; Doria, Roberta; Menichetti, Francesco; Bongiorni, Maria Grazia; Lazzeri, Elena; Mariani, Giuliano

doi:10.1016/j.jcmg.2013.08.001

Cited by 146 publications

(102 citation statements)

References 33 publications

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“…[ 18 F]FDG PET/CT in association with Duke criteria also allowed reclassifying most of cases initially classified as¨possible¨IE [18]. Erba et al also reported a good diagnostic accuracy (94%) of 99m TC-HMPAO WBC SPECT/CT for CIED infection and for distinguishing infection limited to the pocket or leads from a more severe infection affecting the whole device [23] (Table 2). Therefore, both imaging approaches can be of help in patients with suspected CDRIE (ESC class IIb recommendations) [5].…”

Section: Cardiac Device-related Iementioning

confidence: 99%

Radionuclide Imaging of Infective Endocarditis: State of Art and Future Perspective

Marchetta

Withofs

Erba

et al. 2017

Curr Cardiovasc Imaging Rep

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Purpose of Review Infectious endocarditis is a serious disease requiring rapid diagnosis and accurate risk stratification to offer the best therapeutic strategy. Infection of prosthetic valve (PV) and cardiovascular implantable electronic device (CIED) is increasing due to the ageing of the population and the growing number of implants. Foreign material infection remains clinically challenging given the limitation of ultrasound techniques in this context whereas the diagnosis must be precocious. Recent Findings 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ([ 18 F]FDG PET/CT) and radiolabelled leukocytes single-photon emission computed tomography/computed tomography (SPECT/CT) are commonly used for this purpose.Summary In the present article, we summarized the available evidence for the use of nuclear imaging for the evaluation of infectious endocarditis.

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Section: Cardiac Device-related Iementioning

confidence: 99%

Radionuclide Imaging of Infective Endocarditis: State of Art and Future Perspective

Marchetta

Withofs

Erba

et al. 2017

Curr Cardiovasc Imaging Rep

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“…Cep infeksiyonuna sıklıkla "lead" tutulumu eşlik etmiştir. 26 Sintigrafisi negatif olan hiçbir hastada, 12 aylık izlemide cihaz enfeksiyonu gelişmemiştir. Duke kriterlerinin duyarlılığı ise %77 olarak bildirilmiştir.…”

Section: Manyeti̇k Rezonans Görüntülemeunclassified

“…Ateş ve sepsis tablosunda, lökosit sintigrafisiyle İK cihaz enfeksiyonu %95'lik negatif prediktif değerle dışlanmıştır. 26 Protez kapak veya İK cihaz enfeksiyonu tanı-sında 18 F-floro-deoksiglikoz (FDG)-PET/BT kullanılarak pek çok çalışma yapılmıştır. 23,24,[27][28][29] Protez kapaklı 72 hastalık bir çalışmada, Duke kriterlerine, anormal FDG tutulumun eklenmesiyle duyarlılık %70'den %97'ye çıkmıştır.…”

Section: Manyeti̇k Rezonans Görüntülemeunclassified

“…[22][23][24][25][26][27] Hastaların %60'ında perivalvüler apse ve kapakta ayrılma gelişmektedir. Bunlar cerrahi tedaviyi gerektirmektedir.…”

Section: Protez Kapak Endokardi̇ti̇unclassified

“…Lökosit sintigrafisi ve PET/BT, tanı ve tedavi yönetimini iyileştirmektedir. [26][27][28][29] Basit yüzeysel yara yeri enfeksiyonu dışında, genellikle tüm sistem ("lead"ler ve jeneratör) çıkarılmalıdır. Böylece İK cihaz enfeksiyon mortalitesi azalır.…”

Section: İntrakardi̇yak Ci̇haz Enfeksi̇yonuunclassified

See 2 more Smart Citations

Infective Endocarditis: Diagnosis, Treatment and Prevention: Review

Doğan¹,

Gürbüz²

2016

Turkiye Klinikleri J Cardiovasc Sci

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Management Considerations in Infective Endocarditis

Wang

Gaca

Chu

2018

JAMA

301

209

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ndocarditis is an infection of the cardiac endothelium and can present as either acute or subacute disease. Acute infective endocarditis advances rapidly, presenting with a sudden onset of high fever, rigors, sepsis, and systemic complications. This presentation alone is indistinguishable from other causes of sepsis, but when there is also a new-onset heart murmur, a diagnosis of acute infective endocarditis should be considered. In contrast, subacute infective endocarditis can be difficult to diagnose. Patients develop nonspecific symptoms such as fatigue, dyspnea, or weight loss over several weeks to months. Fever may or may not be present. Although endocarditis is commonly associated with a heart murmur due to valve regurgitation, new murmurs are present in less than half of cases (Table 1). 1,2 Janeway lesions or Osler nodes are classic diagnostic findings (Figure 1), but they are present in fewer than 5% of cases. Imaging can reveal embolic phenomena such as pulmonary and splenic emboli (Figure 2). Infective endocarditis should be suspected when patients present with either an acute or subacute illness when infective endocarditis risk factors are present (Box 1). In general, Staphylococcus aureus infection causes acute, aggressive infections, and the more indolent pathogens, viridans group streptococci or coagulase-negative staphylococci, cause subacute infective endocarditis. MethodsWe conducted a literature search of the PubMed database from January 2008 through March 2018. The selection, including clinical trials, observational studies, review articles, and society guidelines, was limited to studies published in English. We reviewed the reference articles that were cited in the guidelines IMPORTANCE Infective endocarditis occurs in approximately 15 of 100 000 people in the United States and has increased in incidence. Clinicians must make treatment decisions with respect to prophylaxis, surgical management, specific antibiotics, and the length of treatment in the setting of emerging, sometimes inconclusive clinical research findings.OBSERVATIONS Community-associated infective endocarditis remains the predominant form of the disease; however, health care accounts for one-third of cases in high-income countries. As medical interventions are increasingly performed on older patients, the disease incidence from cardiac implanted electronic devices is also increasing. In addition, younger patients involved with intravenous drug use has increased in the past decade and with it the proportion of US hospitalization has increased to more than 10%. These epidemiological factors have led to Staphylococcus aureus being the most common cause in high-income countries, accounting for up to 40% of cases. The mainstays of diagnosis are still echocardiography and blood cultures. Adjunctive imaging such as cardiac computed tomographic and nuclear imaging can improve the sensitivity for diagnosis when echocardiography is not conclusive. Serological studies, histopathology, and polymerase chain reaction assays have distinct ro...

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Radiolabeled WBC Scintigraphy in the Diagnostic Workup of Patients With Suspected Device-Related Infections

Cited by 146 publications

References 33 publications

Radionuclide Imaging of Infective Endocarditis: State of Art and Future Perspective

Radionuclide Imaging of Infective Endocarditis: State of Art and Future Perspective

Infective Endocarditis: Diagnosis, Treatment and Prevention: Review

Management Considerations in Infective Endocarditis

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