Radiologic findings of lobular carcinoma in situ: Mammography and ultrasonography

Choi, Bomi; Kim, Sung Hun; Park, Chang Suk; Suk, Eun; Lee, Ah Won

doi:10.1002/jcu.20772

Cited by 16 publications

(11 citation statements)

References 20 publications

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“…These tendencies suggest that combined lobular carcinomas could be detected in the earlier stage. On the other hand, pure lobular cases were of all invasive carcinoma, although this is partly caused by the clinical difficulty of detecting LCIS without abnormal signs in the mammogram . It is noteworthy that lobular and ductal components coexisted in the neighborhood and were distributed contiguously.…”

Section: Discussionmentioning

confidence: 99%

Histopathological and clonal study of combined lobular and ductal carcinoma of the breast

Tazaki

Shishido‐Hara

Mizutani

et al. 2013

Pathology International

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Lobular carcinoma in situ (LCIS) clinically constitutes a risk factor for the subsequent development of either invasive lobular carcinoma (ILC) or invasive ductal carcinoma (IDC). In order to approach the possibility of this common precursor of both ILC and IDC, we investigated combined lobular and ductal carcinomas. Thirty-two cases of lobular carcinoma were picked up out of 773 cases of operated breast carcinomas. The histopathological detailed re-examination using immunostain of E-cadherin and β-catenin revealed a rather high frequency of combined lobular carcinomas than previous reports. Clinicopathologically, combined lobular carcinomas were younger and smaller than pure lobular carcinomas, and the cytological atypia was relatively low. These results suggested that combined lobular carcinomas could be detected in the earlier stage of breast cancer. Furthermore, the lobular and ductal components of combined carcinomas coexisted in the neighborhood and were distributed contiguously. The immunohistochemical phenotypes of both components were accorded in most combined cases. A genetic analysis using methylation-specific PCR on the HUMARA gene demonstrated that the same allele was inactivated in both lobular and ductal components in all detectable cases of combined carcinoma. Therefore, it is reasonable to assume that both lobular and ductal components of combined carcinomas are clonal and derived from the LCIS as the common precursor lesion, which may contradict the conventional concept that the lobular and ductal carcinomas arise from distinct differentiation pathways.

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Section: Discussionmentioning

confidence: 99%

Histopathological and clonal study of combined lobular and ductal carcinoma of the breast

Tazaki

Shishido‐Hara

Mizutani

et al. 2013

Pathology International

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“…Breast microcalcifications are considered an important finding for the diagnosis of breast cancer, making their correct visualization and analysis crucial for early detection. [5][6][7][8][9][11][12][13][24][25][26][27][28][29][30][31] Mammography is considered the only reliable method to identify and classify microcalcifications. [1][2][3][4][5][6][7][8][9][10][11][12] Current US technology is not considered a reliable method for the detection or evaluation of microcalcifications.…”

Section: Discussionmentioning

confidence: 99%

New Image Processing Technique for Evaluating Breast Microcalcifications

Machado

Eisenbrey

Cavanaugh

et al. 2012

Journal of Ultrasound in Medicine

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“…Its ability to evaluate microcalcifications in detail is an important asset, since microcalcifications are established important findings in the diagnosis of several types of breast cancer. Microcalcifications that are considered suspicious (ie, BI‐RADS categories 4 and 5) have to be analyzed histologically to establish a diagnosis and therefore require biopsy, most commonly a stereotactic procedure guided by mammography . However, there are limitations to this procedure, which are usually technical: breast compression thickness may be insufficient for the operation of the biopsy device; the calcifications may be in a location that cannot be brought into the field of view of the image receptor; and calcifications may be too faint to be visible on the stereotactic receptor …”

Section: Discussionmentioning

confidence: 99%

“…The use of mammography is established as a screening method for breast cancer with high sensitivity (63%–96%) and specificity (87%–97%), and it is also the reference standard for detection of breast microcalcifications, which are considered important findings for the diagnosis of breast cancer . Mammography is also used to assess the morphologic characteristics of calcifications and to assign a level of suspicion (LOS) .…”

mentioning

confidence: 99%

Characterization of Breast Microcalcifications Using a New Ultrasound Image‐Processing Technique

Machado

Eisenbrey

Stanczak

et al. 2018

J of Ultrasound Medicine

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Objectives-To evaluate a new commercial image-processing technique (MicroPure; Toshiba America Medical Systems, Tustin, CA) for detection and characterization of breast microcalcifications in patients undergoing stereotactic or ultrasound-guided biopsies using mammography as the reference standard.Methods-One hundred female patients, with a total of 104 lesions, scheduled for an image-guided biopsy of an area with breast microcalcifications (identified on a prior mammogram) underwent MicroPure examinations of the breast using an Aplio XG scanner (Toshiba America Medical Systems) with a broadbandwidth linear array. MicroPure combines nonlinear imaging and speckle suppression to mark suspected calcifications as white spots in a blue overlay image. Four independent and blinded readers (2 radiologists and 2 physicists) analyzed 208 digital clips consisting of dual grayscale ultrasound and MicroPure imaging, counting the number of microcalcifications seen with MicroPure. The observers also assessed the level of suspicion on a qualitative, visual analog, 6-point scale from 0 (no findings) over 1 (benign) to 5 (malignant).Results-The mean number of microcalcifications ± SD seen was 6.3 ± 3.5, whereas mammography saw 28.9 ± 24.6 (P = .66). When the MicroPure level of suspicion scores were compared with pathologic results using a receiver operating characteristic curve analysis, the areas under the curve ranged from 0.54 to 0.59. Nonetheless, malignant cases were seen to have significantly more microcalcifications than benign cases (mean number of microcalcifications, 6.9 ± 5.1 versus 5.3 ± 3.7; P = .02).Conclusions-MicroPure can be used to identify areas with breast microcalcifications but cannot effectively characterize such areas. Instead, MicroPure may represent a new imaging method for guiding a biopsy to areas of microcalcifications.T he use of mammography is established as a screening method for breast cancer with high sensitivity (63%-96%) and specificity (87%-97%), and it is also the reference standard for detection of breast microcalcifications, 1-8 which are considered important findings for the diagnosis of breast cancer. 3,[9][10][11][12][13][14][15][16] Mammography is also used to assess the morphologic characteristics of calcifications and to assign a level of suspicion (LOS).

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Radiologic findings of lobular carcinoma in situ: Mammography and ultrasonography

Abstract: LCIS is frequently mammographically occult, and an incidental finding on routine screening mammograms, usually because of microcalcifications. LCIS, a high-risk lesion, can mimic invasive carcinoma on US.

Cited by 16 publications

References 20 publications

Histopathological and clonal study of combined lobular and ductal carcinoma of the breast

Histopathological and clonal study of combined lobular and ductal carcinoma of the breast

New Image Processing Technique for Evaluating Breast Microcalcifications

Characterization of Breast Microcalcifications Using a New Ultrasound Image‐Processing Technique

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