W e report a case of mucosa-associated lymphoid tissue (MALT) lymphoma involving multiple organs including the lung. A 78-year-old woman presented with a left asymptomatic submandibular mass that had been present for 2 months. Her chest radiograph and computed tomographic (CT) scan revealed multiple micronodules and thickening of bronchovascular bundles, suggestive of lung diseases with lymphangitic spread. Lung histology showed extranodal marginal zone B-cell lymphoma of MALT type, and CT scans and bone marrow aspiration revealed the involvement of the submandibular gland, abdominal lymph nodes, and bone marrow. Treatment of rituximab alone led to a partial response of the tumors. Although MALT lymphomas tend to be localized, multiple-organ MALT lymphoma should be considered in the differential diagnosis of lung diseases with a lymphangitic pattern.
DISCUSSIONMALT lymphomas are low-grade lymphomas. They derive from marginal zone B cells that surround the mantle zone and germinal center and are classified as extranodal marginal zone B-cell lymphoma of MALT type, a distinct subgroup of non-Hodgkin's lymphomas. 2 MALT lymphomas tend to remain localized, but involvement of multiple muco-