Radiological findings and clinical features of thoracic immunoglobulin G4-positive plasma cell granuloma: two cases

Abstract

Plasma cell granulomas, inflammatory pseudotumours and myofibroblastomas are synonymous with characteristic plasma cell infiltration in various body organs including the pancreas, liver, retroperitoneum and mediastinal structures causing idiopathic fibrosclerosis. Recently, a new concept has arisen regarding the relationship between immunoglobulin (Ig)G4-positive cell infiltration and idiopathic systemic fibrosclerosis. We report two cases showing IgG4-positive cell infiltration in the lung presenting as lung nodules with or without extrapulmonary manifestations.

What an endoscopist should know about immunoglobulin-G4-associated disease of the pancreas and biliary tree

“…As type 2 AIP is thought not to belong to the spectrum of IgG4-associated disease, in this review we will focus only on type 1 AIP. The list of organs that can be affected by ISD has expanded from the pancreas [4 -6], the biliary tree, gallbladder, and liver [7], the retroperitoneum [8,9], the salivary, parotid, and lacrimal glands [10,11], and the kidney [12], to the lungs [13,14], the lymphatic system, the prostate [ Autoimmune pancreatitis (AIP) and IgG4-associated cholangitis (IAC) are the recently recognized pancreatobiliary manifestations of IgG4associated systemic disease (ISD). Clinically, ISD of the pancreas and/or biliary tree may mimic pancreatic cancer, sclerosing cholangitis, or cholangiocarcinoma.…”