Radiological findings in 31 patients with chondroblastoma in tubular and non-tubular bones

Abstract

INTRODUCTIONChondroblastoma (CB) is a rare, benign, cartilaginous lesion of the bones that accounts for less than 1% of primary bone tumours.(1,2) It typically develops from the epiphysis of skeletally immature patients. (3,4) Peak incidence of CB is seen in the second decade of life, (5,6) and has been reported to occur more frequently in men than in women. (5,(7)(8)(9)(10) Although CB has a predilection for tubular bones such as the humerus, femur, tibia and metatarsus, (7,11) it can also be found in non-tubular bones (NTBs) such as flat bones (i.e. skull, maxilla and pelvis) (7) and epiphysoid bones (i.e. trapezium, (12) cuboid, (13,14) talus (15,16) and patella (17) ).Multifocal benign CB has also been reported. METHODSThis study was approved by the ethics committee at the Ramathibodi Hospital, Bangkok, Thailand (ID-10-52-01). We retrospectively reviewed the medical records of all patients with pathologically proven CB at our hospital during a 37-year period . A total of 31 patients (16 men; 15 women)

Tumor-to-bone distance and radiomic features on MRI distinguish intramuscular lipomas from well-differentiated liposarcomas

“…The ALTs/WDLSs were generally larger than IM lipomas. This illustrated that tumor size may help to characterize malignancy, as reported by previous investigations based on conventional imaging characteristics [ 11 , 12 , 41 , 42 ]. However, in some specific areas, such as an ALT/WDLS of the hand, the lesion is not large, and a large IM lipoma of the thigh is typically not difficult to find, depending on the location and looseness of the surrounding tissue.…”

“…We can observe that this shape difference may also reflect excessive cell proliferation and/or non-lipomatous or nodular fibrous septa, which showed a fluffier consistency in ALTs/WDLSs [ 45 , 46 ]. Tumor shape was also a key characteristic that was visually evaluated in clinical practice [ 12 , 42 ]. Further studies with expanded data sets that include larger IM lipomas or smaller ALTs/WDLSs should be performed to identify important radiomic features in addition to the size- or volume-dependent features.…”

Chondroblastomas presenting in adulthood: a study of 39 patients with emphasis on histological features and skeletal distribution

“…The diagnosis of CB is relatively straightforward in cases with classic morphology occurring in the expected clinical setting; however, diagnostic challenges may occur when these tumours are encountered in older patients. Furthermore, although CB arising in adults has been documented throughout the literature, studies dedicated to the histological features of this tumour in this population are lacking . In fact, to date there is only a single publication specifically describing these tumours in adults and this study, by Angelini et al , focused on the clinical features and outcomes in a series of 23 adults.…”

“…Furthermore, although CB arising in adults has been documented throughout the literature, studies dedicated to the histological features of this tumour in this population are lacking. [2][3][4][5][6][7][8][9][10][11][12] In fact, to date there is only a single publication specifically describing these tumours in adults and this study, by Angelini et al, 7 focused on the clinical features and outcomes in a series of 23 adults. We sought to better characterise the pathological features of CB arising in patients 20 years of age and above focusing on the morphological spectrum in this age group to facilitate accurate diagnosis.…”

Lumps, bumps, and…nerve-end stumps? A collection of guidelines for safe in-office lipoma excision

“…Most lipoma diagnoses can be made clinically, however, masses greater than 5 cm, and those with a rapid rate of growth should be evaluated with magnetic resonance imaging (MRI) for further characterization. [ 10 11 ] If the clinical diagnosis is not clear, the clinician should not pursue in-office excision. Further imaging, pathological sampling via biopsy, or specialty consultation may be employed for the determination of diagnosis prior to excision.…”