Radiological Physics Characteristics of the Extracted Heavy Ion Beams of the Bevatron

Tobias, Cornelius A.; Lyman, John; Chatterjee, A.; Howard, J.; Maccabee, H.D.; Raju, M. R.; Smith, Alan Р.; Sperinde, J.; Welch, G. P.

doi:10.1126/science.174.4014.1131

Cited by 55 publications

(27 citation statements)

References 5 publications

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“…As compared with conventional photon beam treatment, ion beam radiotherapy takes advantage of the favorable depthdose distribution of ions (Bragg curve) expressed by the highest dose deposition deep in the tissue (1)(2)(3). On the basis of the advantageous physical properties, proton beam therapy is currently used in several centers in the United States, Europe, and Asia (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Quantification of the Relative Biological Effectiveness for Ion Beam Radiotherapy: Direct Experimental Comparison of Proton and Carbon Ion Beams and a Novel Approach for Treatment Planning

Elsässer

Weyrather

Friedrich

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

292

320

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Section: Introductionmentioning

confidence: 99%

Quantification of the Relative Biological Effectiveness for Ion Beam Radiotherapy: Direct Experimental Comparison of Proton and Carbon Ion Beams and a Novel Approach for Treatment Planning

Elsässer

Weyrather

Friedrich

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

292

320

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“…While intensity modulated radiation therapy (IMRT) and image guided radiation therapy (IGRT) using photons are two outstanding examples of such recent developments in radiation therapy [1], the most notable instance in the field of a vastly improved therapeutic gain would be that derived from charged particle radiation therapies with accelerated carbon ions or protons [1]. Accelerated carbon ions and protons have been very successfully used for treating solid cancers primarily due to their advantageous property of excellent physical dose-distribution and deposition around the Bragg peak [2,3]. Several recent clinical studies have reported that outcomes from charged particle beam radiation therapy yield equivalent or superior outcomes to surgical modalities in a number of cases such as prostate, lung, head and neck, bone and soft tissue tumors [4,5].…”

Section: Introductionmentioning

confidence: 99%

Comparison of human chordoma cell-kill for 290 MeV/n carbon ions versus 70 MeV protons in vitro

Fujisawa

Genik

Kitamura³

et al. 2013

Radiat Oncol

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BackgroundWhile the pace of commissioning of new charged particle radiation therapy facilities is accelerating worldwide, biological data pertaining to chordomas, theoretically and clinically optimally suited targets for particle radiotherapy, are still lacking. In spite of the numerous clinical reports of successful treatment of these malignancies with this modality, the characterization of this malignancy remains hampered by its characteristic slow cell growth, particularly in vitro.MethodsCellular lethality of U-CH1-N cells in response to different qualities of radiation was compared with immediate plating after radiation or as previously reported using the multilayered OptiCell™ system. The OptiCell™ system was used to evaluate cellular lethality over a broad dose-depth deposition range of particle radiation to anatomically mimic the clinical setting. Cells were irradiated with either 290 MeV/n accelerated carbon ions or 70 MeV accelerated protons and photons and evaluated through colony formation assays at a single position or at each depth, depending on the system.ResultsThere was a cell killing of approximately 20–40% for all radiation qualities in the OptiCell™ system in which chordoma cells are herein described as more radiation sensitive than regular colony formation assay. The relative biological effectiveness values were, however, similar in both in vitro systems for any given radiation quality. Relative biological effectiveness values of proton was 0.89, of 13–20 keV/μm carbon ions was 0.85, of 20–30 keV/μm carbon ions was 1.27, and >30 keV/μm carbon ions was 1.69. Carbon-ions killed cells depending on both the dose and the LET, while protons depended on the dose alone in the condition of our study. This is the first report and characterization of a direct comparison between the effects of charged particle carbon ions versus protons for a chordoma cell line in vitro. Our results support a potentially superior therapeutic value of carbon particle irradiation in chordoma patients.ConclusionCarbon ion therapy may have an advantage for chordoma radiotherapy because of higher cell-killing effect with high LET doses from biological observation in this study.

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“…Clinical application of protons and carbon ions for human cancer treatment has been expanding and has achieved significantly improved clinical outcomes for a number of tumor types, including OSA in non-resectable tumors (8). Unlike conventional photon radiation, protons and carbon ions may be manipulated to release the majority of their energy only when they reach their target (7,9). This property is known as the Bragg peak.…”

Section: Introductionmentioning

confidence: 99%

“…This property is known as the Bragg peak. Particle radiation therapy offers the possibility of a significantly increased dose of ionizing radiation to the tumor with very little dose deposited in the normal tissue (7)(8)(9). Particle radiation therapy has the potential to be considered as an alternative modality for the treatment of canine and human OSA in the future.…”

Section: Introductionmentioning

confidence: 99%

Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

et al. 2016

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Abstract. Heavy ions, characterized by high linear energy transfer (LET) radiation, have advantages compared with low LET protons and photons in their biological effects. The application of heavy ions within veterinary clinics requires additional background information to determine heavy ion efficacy. In the present study, comparison of the cell-killing effects of photons, protons and heavy ions was investigated in canine osteosarcoma (OSA) cells in vitro. A total of four canine OSA cell lines with various radiosensitivities were irradiated with 137 Cs gamma-rays, monoenergetic proton beams, 50 keV/µm carbon ion spread out Bragg peak beams and 200 keV/µm iron ion monoenergetic beams. Clonogenic survival was examined using colony-forming as says, and relative biological effectiveness (RBE) values were calculated relative to gamma-rays using the D 10 value, which is determined as the dose (Gy) resulting in 10% survival. For proton irradiation, the RBE values for all four cell lines were 1.0-1.1. For all four cell lines, exposure to carbon ions yielded a decreased cell survival compared with gamma-rays, with the RBE values ranging from 1.56-2.10. Iron ions yielded the lowest cell survival among tested radiation types, with RBE values ranging from 3.51-3.69 observed in the three radioresistant cell lines. The radiosensitive cell line investigated demonstrated similar cell survival for carbon and iron ion irradiation. The results of the present study suggest that heavy ions are more effective for killing radioresistant canine OSA cells when compared with gamma-rays and protons. This markedly increased efficiency of cell killing is an attractive reason for utilizing heavy ions for radioresistant canine OSA.

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Radiological Physics Characteristics of the Extracted Heavy Ion Beams of the Bevatron

Cited by 55 publications

References 5 publications

Quantification of the Relative Biological Effectiveness for Ion Beam Radiotherapy: Direct Experimental Comparison of Proton and Carbon Ion Beams and a Novel Approach for Treatment Planning

Quantification of the Relative Biological Effectiveness for Ion Beam Radiotherapy: Direct Experimental Comparison of Proton and Carbon Ion Beams and a Novel Approach for Treatment Planning

Comparison of human chordoma cell-kill for 290 MeV/n carbon ions versus 70 MeV protons in vitro

Relative biological effectiveness in canine osteosarcoma cells irradiated with accelerated charged particles

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