Radiological progression of osteoarthritis: an 11 year follow up study of the knee.

Spector, Tim D.; Dacre, Jane; Harris, Pat; Huskisson, E.C.

doi:10.1136/ard.51.10.1107

Cited by 149 publications

(87 citation statements)

References 8 publications

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“…Ledingham et al (21) reported an association between sex and the change in cyst number but not between sex and change in K/L grade or joint space narrowing (JSN). Miyazaki et al (22), Schouten et al (37), Spector et al (39), and Wolfe and Lane (45) found no significant association between sex and progression of knee OA.…”

Section: Resultsmentioning

confidence: 96%

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Belo¹,

Berger²,

Reijman³

et al. 2007

Arthritis & Rheumatism

167

132

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Objective. To provide an overview of prognostic factors of knee osteoarthritis (OA) progression. Methods. We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were assessed for methodologic quality. Study characteristics and associations were extracted and the results were summarized according to a best evidence synthesis. Results. Of the 1,004 studies found, 37 met the inclusion criteria. Methodologic quality was assessed and only highquality studies were included (n ‫؍‬ 36). The best evidence synthesis yielded strong evidence that hyaluronic acid serum levels and generalized OA are predictive for progression of knee OA. Sex, knee pain, radiologic severity, knee injury, quadriceps strength, and regular sport activities were not predictive. Conflicting evidence for associations was found for several factors including body mass index and age. Limited evidence for an association with progression of knee OA was found for several factors, including the alignment (varus/valgus) of the joint. Limited evidence for no association with progression of OA was also found for several factors, including meniscectomy, several markers of bone or cartilage turnover, and the clinical diagnosis of localized OA. Conclusion. Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting.

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Section: Resultsmentioning

confidence: 96%

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Belo¹,

Berger²,

Reijman³

et al. 2007

Arthritis & Rheumatism

167

132

View full text Add to dashboard Cite

show abstract

“…If studies of the same cohort presented different information, reported on different prognostic factors (28,29), or presented results after different followup periods (30,31), both studies were included. In total, 18 studies were included in this review (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44). A list of excluded studies is presented in Appendix 1 on the NIVEL Web site (available at: http://www.nivel.nl/systeem/scripts/downloadtracker.…”

Section: Resultsmentioning

confidence: 99%

“…Twelve collected data prospectively (28,30 -33, 35,37,38,40-43) and 3 used retrospective data collection methods (27,34,39). The other 3 articles used both pro- No high-quality studies could be found spective and retrospective data collection methods (29,36,44). The study population in 14 of the included studies consisted of patients with knee OA.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Course of functional status and pain in osteoarthritis of the hip or knee: A systematic review of the literature

Dijk

Dekker

Veenhof

et al. 2006

Arthritis & Rheumatism

221

149

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Objective. To systematically review studies describing the course of functioning in patients with osteoarthritis (OA) of the hip or knee and identifying potential prognostic factors. Methods. A systematic search was performed. Studies involving patients with hip or knee OA, >6 months of followup, and outcome measures on functional status or pain were included. Methodologic quality was assessed using a standardized set of 11 criteria; a qualitative data analysis was performed.Results. Approximately 6,500 titles and abstracts were screened and 48 publications were considered for inclusion. Eighteen studies, 4 of which met the high methodologic quality criteria, were included. For hip OA, there was limited evidence that functional status and pain do not change during the first 3 years of followup. After 3 years, however, a worsening of functional status and pain was seen. For knee OA, there was conflicting evidence for the first 3 years and limited evidence for worsening of pain and functional status after 3 years. Furthermore, limited evidence was established for negative associations between future functional status and laxity, proprioceptive inaccuracy, age, body mass index, and knee pain intensity. In contrast, greater muscle strength, better mental health, better self-efficacy, social support, and more aerobic exercise were protective factors in the first 3 years. Conclusion. Pain and functional status in hip or knee OA seem to deteriorate slowly, with limited evidence for worsening after 3 years of followup. In specific subgroups, prognosis in the first 3 years of followup was either worse or better, as both risk factors and protective factors were identified. Prognostic factors included biomechanical factors, psychological factors, clinical factors, and treatment modalities. To strengthen the evidence, further high-quality longitudinal research on hip or knee OA functioning is needed.

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“…Although few studies provided sample size calculation (item R), sample size was considered adequate for analysis in 28 of the 30 included studies, based on a ratio of 10 subjects per prognostic variable analyzed. The majority of studies were longitudinal cohorts, except 4 studies that used subjects recruited either partly or wholly from RCTs (24,34,35,47). This resulted in a good overall score for item I.…”

Section: Assessment Of Biasmentioning

confidence: 99%

Patient characteristics that predict progression of knee osteoarthritis: A systematic review of prognostic studies

Chapple

Nicholson

Baxter

et al. 2011

Arthritis Care & Research

126

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Radiological progression of osteoarthritis: an 11 year follow up study of the knee.

Cited by 149 publications

References 8 publications

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies

Course of functional status and pain in osteoarthritis of the hip or knee: A systematic review of the literature

Patient characteristics that predict progression of knee osteoarthritis: A systematic review of prognostic studies

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