Radiological properties of nanocomposite Fricke gel dosimeters for heavy ion beams

Maeyama, Takashige; Fukunishi, Nobuhisa; Ishikawa, Kenichi L.; Fukasaku, Kazuaki; Fukuda, Satoshi

doi:10.1093/jrr/rrw025

Cited by 36 publications

(27 citation statements)

References 37 publications

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“…Depth vs dose distribution across our T-175 flask was visually represented utilizing a Fricke gel dosimeter, as previous studies have reported ferrous xylenol gels can be used as dosimeters and can therefore provide a quality method for detecting dose distribution 20,21 . Irradiation oxidizes Fe 2+ to Fe 3+ which changes the color of the originally yellow gel to various orange-color combinations depending on the dosage at that specific depth.…”

Section: Resultsmentioning

confidence: 99%

Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak

Buglewicz

Banks

Hirakawa³

et al. 2019

Sci Rep

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The sharp high dose Bragg peak of a carbon-ion beam helps it to deliver the highest dosage to the malignant cells while leaving the normal cells relatively unharmed. However, the precise range in which it distributes dosages that significantly induce cell death or genotoxicity surrounding its Bragg peak remains unclear. To evaluate biological effects of carbon-ion radiation through entrance to post Bragg peak in a single biological system, CHO and xrs5 cells were cultured in T-175 cell culture flasks and irradiated with 290 MeV/n monoenergetic carbon-ions with initial dosages upon entrance to the flask of 1, 2, or 3 Gy for cell survival assays or 1 Gy for cytokinesis block micronuclei assays. Under all initial dosages, the biological Bragg peak and the highest micronuclei formation was observed at the depth of 14.5 cm. Moreover, as the initial dosage increased the range displaying a significant decrease in survival fraction increased as well ( P < 0 . 0001 ). Intriguingly from 1 Gy to 3 Gy, we observed a significant increase in reappearance of colony formation depth ( P < 0 . 05 ), possibly indicating the nuclear fragmentation lethality potential of the carbon-ion. By means of our single system approach, we can achieve a more comprehensive understanding of biological effects surrounding of carbon-ions Bragg peak.

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Section: Resultsmentioning

confidence: 99%

Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak

Buglewicz

Banks

Hirakawa³

et al. 2019

Sci Rep

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“…It should be noted that HD-V2 Gafchromic™ films have a different structure from the other Gafchromic™ films as they feature a 12 µm thin active layer on a 97 µm polyester substrate. The LET dependence is common to other types of dosimeters; however, recently developed nanocomposite Fricke gel dosimeters have shown to have no dependence on the LET in a wide LET range [116,117].…”

Section: Radiochromic Films Response To Relevant Physical Quantitiesmentioning

confidence: 99%

Radiochromic Films for the Two-Dimensional Dose Distribution Assessment

Casolaro

2021

Applied Sciences

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Radiochromic films are mainly used for two-dimensional dose verification in photon, electron, and proton therapy treatments. Moreover, the radiochromic film types available today allow their use in a wide dose range, corresponding to applications from low-medical diagnostics to high-dose beam profile measurements in charged particle medical accelerators. An in-depth knowledge of the characteristics of radiochromic films, of their operating principles, and of the dose reading techniques is of paramount importance to exploit all the features of this interesting and versatile radiation detection system. This short review focuses on these main aspects by considering the most recent works on the subject.

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“…PGD was also tested with heavy ion beams[40]. Recently, Maeyama et al used the nano-composite Fricke gel (NC-FG), a type of FGD, with carbon and argon ion beams, whose LET ranged from 10 to 3000 eV/μm[41]. NC-FG showed a consistent dose response for the range of LET tested in their study.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Three-dimensional radiation dosimetry using polymer gel and solid radiochromic polymer: From basics to clinical applications

Watanabe

Warmington

Natanasabapathi

2017

WJR

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Accurate dose measurement tools are needed to evaluate the radiation dose delivered to patients by using modern and sophisticated radiation therapy techniques. However, the adequate tools which enable us to directly measure the dose distributions in three-dimensional (3D) space are not commonly available. One such 3D dose measurement device is the polymer-based dosimeter, which changes the material property in response to radiation. These are available in the gel form as polymer gel dosimeter (PGD) and ferrous gel dosimeter (FGD) and in the solid form as solid plastic dosimeter (SPD). Those are made of a continuous uniform medium which polymerizes upon irradiation. Hence, the intrinsic spatial resolution of those dosimeters is very high, and it is only limited by the method by which one converts the dose information recorded by the medium to the absorbed dose. The current standard methods of the dose quantification are magnetic resonance imaging, optical computed tomography, and X-ray computed tomography. In particular, magnetic resonance imaging is well established as a method for obtaining clinically relevant dosimetric data by PGD and FGD. Despite the likely possibility of doing 3D dosimetry by PGD, FGD or SPD, the tools are still lacking wider usages for clinical applications. In this review article, we summarize the current status of PGD, FGD, and SPD and discuss the issue faced by these for wider acceptance in radiation oncology clinic and propose some directions for future development.

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Radiological properties of nanocomposite Fricke gel dosimeters for heavy ion beams

Cited by 36 publications

References 37 publications

Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak

Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak

Radiochromic Films for the Two-Dimensional Dose Distribution Assessment

Three-dimensional radiation dosimetry using polymer gel and solid radiochromic polymer: From basics to clinical applications

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