Radiological Reasoning: Miliary Disease, Vertebral Osteomyelitis, and Soft-Tissue Abscesses

Wilde, Gregory E.; Emery, Christine; Lally, James F

doi:10.2214/ajr.07.7013

Cited by 16 publications

(4 citation statements)

References 24 publications

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“…Lesions become evident in a subacute or chronic fashion and may easily be mistaken for malignancy, tuberculosis or other granulomatous diseases 5. Symptoms depend on the site of infection and may be difficult to differentiate from infection of these organs due to other pathogens.…”

Section: Discussionmentioning

confidence: 99%

Coccidioidomycosis masquerading as malignancy

Arora

Taneja²,

Reyes-Sacin³

et al. 2012

Case Reports

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Section: Discussionmentioning

confidence: 99%

Coccidioidomycosis masquerading as malignancy

Arora

Taneja²,

Reyes-Sacin³

et al. 2012

Case Reports

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“…Similarly, vertebral coccidioidomycosis may also be misdiagnosed, being mistaken for spinal metastasis [44,45], tuberculous spondylitis (Pott's disease: tuberculosis with spine involvement), pyogenic spondylitis (spinal infection from other bacteria origin such as Staphylococcus aureus) [27] or other granulomatous diseases [45]. One report by Wesselius et al [46] examined a case of vertebral coccidioidomycosis that appeared with similar clinical and radiological features as those of vertebral tuberculosis yet indicated differences to distinguish the conditions.…”

Section: Clinical Reportsmentioning

confidence: 99%

Coccidioidomycosis Osteoarticular Dissemination

Moni¹,

Loots²,

Weilhammer³

2023

Preprint

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Valley fever or coccidioidomycosis is a pulmonary infection caused by several species of coccidi-oides (Cocci) fungi that is endemic to California and Arizona. Skeletal coccidioidomycosis ac-counts for about half of disseminated infections, with the vertebral spine being the preferred site of dissemination. Most cases of skeletal coccidioidomycosis progress to bone destruction or spread to adjacent structures such as joints, tendons, and other soft tissues causing significant pain and restricting mobility. Manifestations of such cases are usually non-specific, making di-agnosis very challenging, especially in non-endemic areas. In this review, we explore case reports of dissemination of coccidioidomycosis to bones and/or joints to highlight key differential fea-tures with other conditions or diseases and highlight opportunities for mechanistic and pre-clinical studies that can help improve diagnostics, prognostics, and treatments.

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“…Similarly, vertebral coccidioidomycosis may also be misdiagnosed, being mistaken for spinal metastasis [54,55], tuberculous spondylitis (Pott's disease: tuberculosis with spine involvement), pyogenic spondylitis (spinal infection from other bacteria origin such as Staphylococcus aureus) [37] or other granulomatous diseases [55]. One report by Wesselius et al [56] examined a case of vertebral coccidioidomycosis that appeared with similar clinical and radiological features as those of vertebral tuberculosis yet indicated differences in distinguishing the conditions.…”

Section: Clinical Reportsmentioning

confidence: 99%

Coccidioidomycosis Osteoarticular Dissemination

Moni,

Wise,

Loots

et al. 2023

JoF

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Valley fever or coccidioidomycosis is a pulmonary infection caused by species of Coccidioides fungi that are endemic to California and Arizona. Skeletal coccidioidomycosis accounts for about half of disseminated infections, with the vertebral spine being the preferred site of dissemination. Most cases of skeletal coccidioidomycosis progress to bone destruction or spread to adjacent structures such as joints, tendons, and other soft tissues, causing significant pain and restricting mobility. Manifestations of such cases are usually nonspecific, making diagnosis very challenging, especially in non-endemic areas. The lack of basic knowledge and research data on the mechanisms defining susceptibility to extrapulmonary infection, especially when it involves bones and joints, prompted us to survey available clinical and animal data to establish specific research questions that remain to be investigated. In this review, we explore published literature reviews, case reports, and case series on the dissemination of coccidioidomycosis to bones and/or joints. We highlight key differential features with other conditions and opportunities for mechanistic and basic research studies that can help develop novel diagnostic, prognostic, and treatment strategies.

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Radiological Reasoning: Miliary Disease, Vertebral Osteomyelitis, and Soft-Tissue Abscesses

Cited by 16 publications

References 24 publications

Coccidioidomycosis masquerading as malignancy

Coccidioidomycosis masquerading as malignancy

Coccidioidomycosis Osteoarticular Dissemination

Coccidioidomycosis Osteoarticular Dissemination

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