Radiolucent implantable electrocardiographic monitoring device based on graphene

Bong, Jihye; Attia, Zachi I.; Vaidya, Vaibhav R.; Jung, Yei Hwan; Padmanabhan, Deepak; Lee, Juhwan; Kim, Hyungsoo; Ladewig, Dorothy J.; Noseworthy, Peter A.; Asirvatham, Samuel J.; Park, Dong Wook; Friedman, Paul A.

doi:10.1016/j.carbon.2019.06.069

Cited by 11 publications

(10 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Capacitive charge transfer is an essential property for biological stimulation due to the reduced chemical changes and tissue damage that occur at the interface between tissue and electrodes. Graphene-based microelectrodes are well known to retain full functionality without degradation of the structural, mechanical, and electrochemical performance for the long term . Because electrosorption progression is expected based on a large number of vacant surface sites of graphene electrodes available for adsorption during the initial stage, the impedance of the microelectrodes initially dropped and then stabilized after a certain amount of time. , In addition, for the graphene-based microelectrodes, the accelerated aging test was performed at the same accelerated aging test condition of the μLED experiment.…”

Section: Resultsmentioning

confidence: 99%

Design and Fabrication of Blue LED-Integrated Graphene Electrodes for Neural Stimulation and Signal Recording

Park

Bong

Jung

et al. 2021

ACS Appl. Electron. Mater.

Self Cite

View full text Add to dashboard Cite

Optogenetics combined with electrocorticography enables simultaneous modulation and recording of neural activity with site-specific precision in a programmable manner. Existing platforms for delivering light to the brain typically consist of external light sources and optical fibers that give rise to considerable physical constraints on natural behavior. Moreover, delivering light onto cortical surfaces through recording devices that comprise opaque electrodes is challenging. In this paper, we overcome both limitations using a fabrication approach that combines an array of mechanically compliant microscale optoelectronic devices with transparent graphene-based electrodes for minimally invasive cortical interfacing. We validate the use of this combined system for the potential widespread use in research and future clinical applications in optogenetics.

show abstract

Section: Resultsmentioning

confidence: 99%

Design and Fabrication of Blue LED-Integrated Graphene Electrodes for Neural Stimulation and Signal Recording

Park

Bong

Jung

et al. 2021

ACS Appl. Electron. Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, there is still lack of safety evaluations and detailed chronic studies of the organs as a result of device penetrations. Other safety challenges of implantable electronics include MRI and X‐ray incompatibility249–251 and electrical current leakages 2. Moreover, novel materials used for biomedical tools and biomedicine need further verification by federal regulators in terms of their safety 252,253.…”

Section: Resultsmentioning

confidence: 99%

Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs

et al. 2020

Self Cite

View full text Add to dashboard Cite

The rapid pace of progress in implantable electronics driven by novel technology has created devices with unconventional designs and features to reduce invasiveness and establish new sensing and stimulating techniques. Among the designs, injectable forms of biomedical electronics are explored for accurate and safe targeting of deep‐seated body organs. Here, the classes of biomedical electronics and tools that have high aspect ratio structures designed to be injected or inserted into internal organs for minimally invasive monitoring and therapy are reviewed. Compared with devices in bulky or planar formats, the long shaft‐like forms of implantable devices are easily placed in the organs with minimized outward protrusions via injection or insertion processes. Adding flexibility to the devices also enables effortless insertions through complex biological cavities, such as the cochlea, and enhances chronic reliability by complying with natural body movements, such as the heartbeat. Diverse types of such injectable implants developed for different organs are reviewed and the electronic, optoelectronic, piezoelectric, and microfluidic devices that enable stimulations and measurements of site‐specific regions in the body are discussed. Noninvasive penetration strategies to deliver the miniscule devices are also considered. Finally, the challenges and future directions associated with deep body biomedical electronics are explained.

show abstract

“…[2] Currently, graphene-based implantable electrodes have been studied in neural recording, electrocardiographic monitoring and pressure sensors, etc. [54] Bong et al…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

Materials and Biomedical Applications of Implantable Electronic Devices

Liu

et al. 2022

Adv Materials Technologies

View full text Add to dashboard Cite

The implantable electronic devices have attracted great attention for solving clinical problems ranging from monitoring psychological states to electro‐organ transplantation. The ongoing challenges are the selection of suitable materials in a target device configuration for biomedical applications. To address the ongoing challenges, there are several interesting questions: what types of electronic materials can be used as the implantable electrodes? What types of materials can be used as the substrates for the implantable electronic devices? What types of materials can be used as membranes and encapsulations? What types of device configurations are there for implantable biomedical applications? What types of applications are for implantable electronic devices? This review will highlight the attempts for addressing these questions. This review will explore the fundamentals and practical aspects of a variety of materials and their biomedical applications in implantable electronic devices. It is anticipated that this review could provide new opportunities for the construction of future implantable electronic devices, as well as related applications for disease diagnosis and therapy.

show abstract

Radiolucent implantable electrocardiographic monitoring device based on graphene

Cited by 11 publications

References 43 publications

Design and Fabrication of Blue LED-Integrated Graphene Electrodes for Neural Stimulation and Signal Recording

Design and Fabrication of Blue LED-Integrated Graphene Electrodes for Neural Stimulation and Signal Recording

Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs

Materials and Biomedical Applications of Implantable Electronic Devices

Contact Info

Product

Resources

About