Abstract:We study the implications of non-standard Higgs Yukawa couplings to light quarks on Higgs-portal dark matter phenomenology. Saturating the present experimental bounds on up-quark, down-quark, or strange-quark Yukawa couplings, the predicted direct dark matter detection scattering rate can increase by up to four orders of magnitude. The effect on the dark matter annihilation cross-section, on the other hand, is subleading unless the dark matter is very light -a scenario that is already excluded by measurements of the Higgs invisible decay width. We investigate the expected size of corrections in multi-Higgsdoublet models with natural flavor conservation, the type-II two-Higgs-doublet model, the Giudice-Lebedev model of light quark masses, minimal flavor violation new physics models, Randall-Sundrum, and composite Higgs models. We find that an enhancement in the dark matter scattering rate of an order of magnitude is possible. Finally, we point out that a discovery of Higgs-portal dark matter could lead to interesting bounds on the light-quark Yukawa couplings.