Radionuclide Assessment in Nocturnal Asthma

Nd, Greyson; Rh, Reid; Yc, Liu; Thomas, P.

doi:10.1097/00003072-198207000-00004

Cited by 16 publications

(3 citation statements)

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“…" In uncontrolled studies surgical treatment ofgastrooesophageal reflux in asthmatic patients with a history suggestive of aspiration has improved asthma control.7' 1516 On the other hand, medical treatment of gastro-oesophageal reflux in patients with asthma and indirect signs of reflux has failed to produce any major effect on respiratory function. '7 8 It is not clear whether the ineffectiveness of medical treatment is due to insufficient prevention of reflux or to poor selection of asthmatic patients with respect to the severity of reflux.…”

Section: Introductionmentioning

confidence: 99%

Effects of ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a double blind crossover study.

Ekström

Lindgren

Tibbling

1989

Thorax

120

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Forty eight patients with moderate to severe asthma were enrolled in a double blind crossover study designed to evaluate the effects of ranitidine treatment, 150 mg twice daily for four weeks, on gastro-oesophageal reflux, asthma control, and bronchial reactivity. All 48 had a history of reflux symptoms and 27 had in addition reflux associated respiratory symptoms. Thirty two patients had objective evidence ofacid reflux on 24 hour pH monitoring (pH ofless than 4 for more than I % of the 24 hours) and 27 patients had a positive result in the acid perfusion test. Reflux symptoms were significantly improved after ranitidine treatment. Ranitidine treatment was associated with modest improvements in nocturnal asthma and daily use of inhaled bronchodilator drugs but there was no significant change in bronchial reactivity, lung function, peak flow, or the number of eosinophils in the blood. Comparisons between the effect of ranitidine treatment on asthma control were performed between patients with and without a history of reflux associated respiratory symptoms, with and without a positive result in the acid perfusion test, and with and without objective evidence of gastrooesophageal reflux. A history of reflux associated respiratory symptoms was the only factor that predicted an improvement in asthma control after ranitidine treatment. These results indicate that antireflux treatment will produce only small improvements in asthma control in asthmatic patients with a history of gastro-oesophageal reflux.

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Section: Introductionmentioning

confidence: 99%

Effects of ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a double blind crossover study.

Ekström

Lindgren

Tibbling

1989

Thorax

120

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“…Asthmatics with GER were fed radiolabeled meals in the evening and then underwent nuclear scanning the following morning. 16,17 Tracer activity over the lung fields was presumed to represent evidence of GER and aspiration. However, less than one half of those studied had positive tracer studies.…”

mentioning

confidence: 99%

A Critical Review of the Studies of the Effects of Simulated or Real Gastroesophageal Reflux on Pulmonary Function in Asthmatic Adults

Field

1999

Chest

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“…In a sub stantial proportion of patients with various pulmonary diseases aspiration has been demonstrated by lung scintigraphy [6,7], In asthmatic patients with proven GER, aspira tion was demonstrated only in a minority [4,[8][9][10][11]. The supposed poor sensitivity of ra dionuclide scanning studies may have been due to too rapid clearing from the stomach before reflux occurred, a too short monitor ing period or the absence of reflux during the night of the examination.…”

Section: Pathophysiologymentioning

confidence: 99%

Gastro-Oesophageal Reflux in Patients with Bronchial Asthma

Depla¹

1989

Digestion

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A case is described with pathological gastro-oesophageal reflux and nighttime bronchial asthma. Treatment with omeprazole resulted not only in improvement of gastro-oesophageal reflux but also in alleviation of asthmatic symptoms and increases in expiratory peak flow values. The possible pathophysiological mechanisms whereby gastro-oesophageal reflux may induce or aggravate asthmatic symptoms are discussed. At present it is not yet possible to predict which patients with bronchial asthma will benefit from antireflux therapy with respect to their pulmonary condition, but such treatment is warranted in all patients with bronchial asthma and proven pathological gastro-oesophageal reflux.

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Radionuclide Assessment in Nocturnal Asthma

Cited by 16 publications

References 0 publications

Effects of ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a double blind crossover study.

Effects of ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a double blind crossover study.

A Critical Review of the Studies of the Effects of Simulated or Real Gastroesophageal Reflux on Pulmonary Function in Asthmatic Adults

Gastro-Oesophageal Reflux in Patients with Bronchial Asthma

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