Radionuclide Measurement of Differential Glomerular Filtration Rate

Ta, Powers; Wj, Stone; Rb, Grove; Jm, Plunkett; Kadir, Sajid; Ja, Patton; Rd, Bowen

doi:10.1097/00004424-198101000-00011

Cited by 37 publications

(8 citation statements)

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“…22 The error in the uncorrected CL 1c value in our data averaged 20%, similar to results from other studies in dogs and humans. 8,17,33 The size of the part of the AUC not used in the calculation was not proportional to the level of renal function (Fig 4), corresponding to findings in humans. 8 The most commonly used correction formula for 2-sample methods in human nephrology is that of Brøchner-Mortensen (B-M).…”

Section: Discussionmentioning

confidence: 61%

The Relationship between Some Plasma Clearance Methods for Estimation of Glomerular Filtration Rate in Dogs with Pyometra

Heiene

Moe

1999

Veterinary Internal Medicne

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The purpose of the present study was to compare different pharmacokinetic models for estimation of glomerular filtration rate (GFR) in 50 dogs with pyometra. GFR was estimated by plasma clearance (CLplasma) of iohexol by four 1-compartment methods (CL1c), a 2-compartment method (CL2c), and the trapezoidal method (CLtr). Regression analysis was performed to establish correction formulas for prediction of CLtr from the CL1c values and to find optimal times of sampling. Standardization of clearance values to body weight (kg), body surface area (m2) and extracellular fluid volume (ECFV) was compared by ranking of values. CLtr and CL2c values were similar, whereas CL1c overestimated CLtr. CLtr could be predicted from 2 samples at 2 and 3 hours after injection, using the formula CLtr = 4.52 + 0.84CL1c - 0.00080(CL1c)2 (R2 = .97). Similar relationships were found when sampling at 2 and 4 hours or at 2, 3 and 4 hours after injection, whereas predictions from the 3- and 4-hour estimates were not optimal (R2 = .79). The 2-sample methods for calculating GFR/ECFV generally produced unreliable predictions of the complete curve GFR/ECFV values. For some dogs, the choice of standardization procedure substantially changed the apparent level of renal function relative to other dogs in the study. We conclude that by applying an appropriate correction formula, GFR may be estimated using 2 blood samples at 2 and 3, or 2 and 4 hours after injection of iohexol when renal function is normal or moderately reduced. The method of standardizing the analysis with respect to body size may influence interpretation of the results substantially.

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Section: Discussionmentioning

confidence: 61%

The Relationship between Some Plasma Clearance Methods for Estimation of Glomerular Filtration Rate in Dogs with Pyometra

Heiene

Moe

1999

Veterinary Internal Medicne

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“…Standard renogram studies are sensitive indexes of relative renal blood flow, tubular function and urinary excretion. [1][2][3] In the physiologic process, glomerular filtration is the first step in urine formation. The relative glomerular filtration rate ͑GFR͒ can be determined from the net activity that accumulates in the kidneys during the 1-2 or 2-3 minute post injection period.…”

Section: Introductionmentioning

confidence: 99%

A dynamic renal phantom for nuclear medicine studies

et al. 2005

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Dynamic radionuclide renal study (renography) provides functional and structural information of the kidney and urinary tract noninvasively. Our purpose in this study is to describe the construction and test results of a dynamic renal phantom with different clinical features of radionuclide renography. The phantom consisted of five pieces of different shaped Plexiglas boxes: Two kidneys, one liver, two square shaped boxes (one heart and one bladder). The bladder was internally divided into two compartments in order to collect each kidney output separately. The dynamic circulation of the phantom was maintained under a hydrostatic pressure approximately equal to 13.3 kPa (average human blood pressure). The standard dose distribution among different organs and different renographic parameters were calculated from series of normal patients study (91 with 99mTc-DTPA, 68 with 99mTc-EC). All the studies were performed with same camera (Siemens Orbiter Digitrac 7500) equipped with LEAP (low energy all purpose) collimator using ADAC Pegasys II analytic package program under the same clinical procedure. Different regions of interest (ROIs) were drawn for concerning organs and counts per second (CPS) were collected for each ROI. The series of renogram curves were generated by phantom-studies with different flow rates for left kidney (LK) and right kidney (RK). The renal index (RI) for an individual study was calculated as the product of two indexes: "Relative Renal Function" (RRF) (water-volume of LK/RK) and "Relative Renal Time" (RRT) (Tmax of LK/RK). The most significant correlation was found in total CPS for LK and RK between the EC group and phantom studies (p < 0.001). The calculated RI values were used to simulate the patients' study with different clinical features. The dynamics were found reproducible. The phantom is suitable for using in calibration and quality control protocols of the renogram procedure used in Nuclear Medicine.

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“…For normal functioning kidneys, BG correction generally does not change the assessment of the RU. 19,29 However, as BG counts are not relative to the kidneys uptake but rather an absolute value of the surrounding tissue, the relative contribution of a poorly functioning kidney would be overestimated when BG correction is not applied. 16 For further uptake quantification, a choice must be made between a method based on only the dorsal image (without depth correction) and that using the GM (with depth correction).…”

Section: Discussionmentioning

confidence: 99%

^99mTc – DMSA absolute and relative renal uptake in cats: procedure and normal values

Vandermeulen

Ham

Dobbeleir

et al. 2011

Journal of Feline Medicine and Surgery

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In this study we investigated the influence of technical factors (positioning, background (BG) correction and attenuation correction) on qualitative and quantitative (absolute (AU) and relative (RU) uptake) assessment of feline kidneys with (99m)technetium labelled dimercaptosuccinic acid ((99m)Tc-DMSA). Eleven healthy adult cats were included. Influence of BG and depth correction on quantitative assessment was evaluated. Depth correction was based on the geometric mean method (using dorsal and ventral images) and the use of two standards placed over each individual kidney. Visual evaluation showed superiority of dorsal and ventral over lateral positioning due to increased separation of the kidneys permitting region of interest (ROI) placement without overlap. No apparent influence of BG correction was found for RU. However, AU was systematically overestimated without BG correction. Depth correction did not seem to affect RU in most cases, however, in some cats the differences were not negligible. The values for AU without depth correction were lower compared to depth corrected values.

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Radionuclide Measurement of Differential Glomerular Filtration Rate

Cited by 37 publications

References 0 publications

The Relationship between Some Plasma Clearance Methods for Estimation of Glomerular Filtration Rate in Dogs with Pyometra

The Relationship between Some Plasma Clearance Methods for Estimation of Glomerular Filtration Rate in Dogs with Pyometra

A dynamic renal phantom for nuclear medicine studies

^99mTc – DMSA absolute and relative renal uptake in cats: procedure and normal values

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