Radiopacity Evaluation of Calcium Aluminate Cement Containing Different Radiopacifying Agents

Aguilar, Fabiano Gamero; Garcia, Lucas da Fonseca Roberti; Rossetto, Hebert Luis; Pardini, Luiz Carlos; Pires‐de‐Souza, Fernanda de Carvalho Panzeri

doi:10.1016/j.joen.2010.10.001

Cited by 39 publications

(48 citation statements)

References 38 publications

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“…However, visualization of CPC is still challenging and several radiopacifying materials are currently employed (bismuth, strontium, barium, colloidal gold, a.o.). 25 In a recent study by Camilleri and Gandolfi, 26 an adequate radiopacity was achieved with the use of 30% zinc oxide and similar results were obtained by the group of Hú ngaro Duarte 27 with zirconium oxide. However, very high concentrations of the embedded material will always (negatively) influence the handling properties of cement in …”

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confidence: 54%

“…A strategy to decrease the concentration of a contrast agent to avoid interferences with physicomechanical performances of the cement 28 is to choose high atomic number compounds. 11 In the study of Aguilar et al, 25 bismuth oxide showed good contrast enhancing properties at a concentration of 20%, while choosing an even higher atomic mass compound as nanometric particulate of tantalum oxide, Hoekstra et al 29 were able to decrease the concentration up to 10% wt/wt. Still, the problem arising from the use of such heavy metal compounds, besides unspecific reactivity, is the lack of information about their metabolic destiny, possible accumulation, and toxicity after being released after CPC degradation.…”

Section: Dual Contrast Agent For Bone Imagingmentioning

confidence: 99%

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Dual Contrast Agent for Computed Tomography and Magnetic Resonance Hard Tissue Imaging

Ventura

Sun²,

Rusu³

et al. 2013

Tissue Engineering Part C: Methods

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Calcium phosphate cements (CPCs) are commonly used bone substitute materials, which closely resemble the composition of the mineral phase of bone. However, this high similarity to natural bone also results in difficult discrimination from the bone tissue by common imaging modalities, that is, plain X-ray radiography and threedimensional computed tomography (CT). In addition, new imaging techniques introduced for bone tissue visualization, like magnetic resonance imaging (MRI), face a similar problem. Even at high MRI resolution, the lack of contrast between CPCs and surrounding bone is evident. Therefore, this study aimed to evaluate the feasibility of a dual contrast agent, traceable with both CT and MRI as enhancers of CPC/bone tissue contrast. Our formulation is based on the use of silica beads as vectors, which encapsulate and carry contrast-enhancing nanoparticles, in our case, colloidal Gold and Superparamagnetic Iron oxide particles (SPIO). The bead suspension was incorporated within a calcium phosphate powder. The resultant cements were then tested both in vitro and in vivo in a femoral condyle defect model in rats. Results showed that the mechanical properties of the cement were not significantly affected by the inclusion of the beads. Both in vitro and in vivo data proved the homogeneous incorporation of the contrast within the cement and its visual localization, characterized by a short-term CT contrast enhancement and a long-term MR effect recognizable by the characteristic blooming shape. Finally, no signs of adverse tissue reactions were noticed in vivo. In conclusion, this study proved the feasibility of a multimodal contrast agent as an inert and biocompatible enhancer of CaP cement versus bone tissue contrast.

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mentioning

confidence: 54%

Section: Dual Contrast Agent For Bone Imagingmentioning

confidence: 99%

Dual Contrast Agent for Computed Tomography and Magnetic Resonance Hard Tissue Imaging

Ventura

Sun²,

Rusu³

et al. 2013

Tissue Engineering Part C: Methods

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“…In addition to the versions containing 20% of radiopacifiers in their composition, a version of EndoBinder without radiopacifier was tested to clarify possible doubts related to the effects of these compounds on the cement cytotoxicity. Considering the radiopacity provided to the cement, Bi 2 O 3 is the most efficient radiopacifier, followed by ZnO and ZrO 2 (20).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

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This study aimed to evaluate the cytotoxicity of a calcium aluminate cement (EndoBinder) containing different radiopacifiers, Bi 2 O 3 , ZnO or ZrO 2 , compared with Mineral Trioxide Aggregate (MTA). According to ISO 10993-12:2012 (E) recommendations, 0.2 g of each cement were applied in transwell inserts and placed in 24-well culture plates containing 1 mL of culture medium (DMEM). After 24 h of incubation, the extracts (DMEM containing components released from the cements) were applied to immortalized odontoblast-like MDPC-23 cells. Cell viability (MTT test), alkaline phosphatase activity (ALP), total protein production and cell morphology (Scanning Electron Microscopy -SEM) were evaluated. The volume of 50 µL of extract was used to determine the chemical elements released by the cements using Energy Dispersive Spectroscopy (EDS). The following groups were established (n=6): NC -negative control (without treatment); EB -EndoBinder without radiopacifier; EBBO -EndoBinder+Bi 2 O 3 ; EBZnO -EndoBinder+ZnO; EBZrOEndoBinder+ZrO 2 and WMTA -White MTA. Data were subjected to statistical analysis (Kruskal-Wallis test, level of significance=5%). Cells exposed to the different versions of EndoBinder presented small reduction in viability, total protein production and ALP activity, with values similar to the NC and WMTA groups (p>0.05). Different elements (C, O, Na, Al, P, Si, Cl, Bi, K) released by the cements were detected in the extracts. However, the cells had no significant changes in their morphology. EndoBinder and MTA did not affect negatively the metabolism of the odontoblastic-like cells, showing it to be cytocompatible, irrespective of the used radiopacifier.

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“…Most endodontic materials contain radiopacifying agents to visualize the root canal filling and to check the healing evolution over time 14 . The rootend filling material should have enough radiopacity to be distinguished from adjacent anatomical structures, such as bones and teeth 1,14,15 .…”

Section: Introductionmentioning

confidence: 99%

“…The use of Bi 2 D 3 with calcium silicate has been shown to be deleterious to the physical properties of the final material, affecting particularly the compressive strength 19 . The bismuth oxide is not inert and retards the hydration of the cement by decreasing its calcium ions release rate, changing its reparative capacity and its physicochemical properties 15 . Barium sulphate and zinc oxide are applied extensively in medical devices 19 .…”

Section: Introductionmentioning

confidence: 99%

Influence of radiopacifier additives on calcium aluminate cement properties

et al. 2014

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The aim of this study was to determine the best radiopaque additive to be incorporated to calcium aluminate cement (CAC) to promote radiopacity. Measurements of optical density were carried out on white MTA and CAC with and without additives such as: polymeric dispersant, plasticizer and various radiopacifiers. The effects of the radiopacifying addition on some properties of CAC were also evaluated. The radiopacity value for CAC-Bi 2 D 3 (25%) was higher than the other radiopacifying agents tested. The addition of ZnD (25%) and 15%ZnD:10%Bi 2 D 3 increased the compressive strength of CAC, whereas for Bi 2 D 3 (25%) containing samples the strength was lower than for the CAC. The ZnD (25%) and 15%ZnD:10%Bi 2 D 3 additions also reduced the apparent porosity. CAC does not have sufficient radiopacity to be distinguished from adjacent anatomic structures, such as dental tissues and bone. The addition of 15%ZnD:10%Bi 2 D 3 can be suggested as the most suitable one to obtain the best compromise between good physical and mechanical properties and ideal radiopacity for clinical purposes.

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Radiopacity Evaluation of Calcium Aluminate Cement Containing Different Radiopacifying Agents

Cited by 39 publications

References 38 publications

Dual Contrast Agent for Computed Tomography and Magnetic Resonance Hard Tissue Imaging

Dual Contrast Agent for Computed Tomography and Magnetic Resonance Hard Tissue Imaging

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

Influence of radiopacifier additives on calcium aluminate cement properties

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