Background: The sellar and parasellar region is an anatomically complex area that represents a critical junction for important contiguous structures. A number of pathological processes occur in the sellar/para/ suprasellar region including: neoplastic, inflammatory, infectious, developmental and vascular abnormalities and the presentation of the various lesions can mimic the pituitary adenonmas clinically, endocrinologically and in the radiological presentation. The overwhelming majority of sellar region masses are pituitary adenomas (85%), followed by craniopharyngiomas (3%), Rathke cleft cysts (2%), meningiomas (1%), and metastases (0.5%); all other lesions, such as hypophysitis, pituicytoma, spindle cell oncocytoma, and granular cell tumor of neurohypophysis, are rare lesions. The purpose here is to study the histopathological spectrum of sellar, suprasellar and parasellar lesion in biopsy specimen received in