Radiopharmaceuticals for cardiac imaging: Current status and future trends

Taillefer, Raymond; Harel, François

doi:10.1007/s12350-018-1194-y

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…However, we expect that the proposed approach will work for 18 F‐flurpiridaz PET imaging . This new 18 F labeled tracer is currently being evaluated in a clinical trial and has significant clinical potential because of its long half‐life, high extraction factor and slow wash‐out rate. Our approach is more important for 18 F based tracers because 18 F has a smaller positron range than other PET radionuclides, hence better spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

Body motion detection and correction in cardiac PET: Phantom and human studies

et al. 2019

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Purpose: Patient body motion during a cardiac positron emission tomography (PET) scan can severely degrade image quality. We propose and evaluate a novel method to detect, estimate, and correct body motion in cardiac PET. Methods: Our method consists of three key components: motion detection, motion estimation, and motion-compensated image reconstruction. For motion detection, we first divide PET list-mode data into 1-s bins and compute the center of mass (COM) of the coincidences' distribution in each bin. We then compute the covariance matrix within a 25-s sliding window over the COM signals inside the window. The sum of the eigenvalues of the covariance matrix is used to separate the list-mode data into "static" (i.e., body motion free) and "moving" (i.e. contaminated by body motion) frames. Each moving frame is further divided into a number of evenly spaced sub-frames (referred to as "sub-moving" frames), in which motion is assumed to be negligible. For motion estimation, we first reconstruct the data in each static and sub-moving frame using a rapid back-projection technique. We then select the longest static frame as the reference frame and estimate elastic motion transformations to the reference frame from all other static and sub-moving frames using nonrigid registration. For motion-compensated image reconstruction, we reconstruct all the list-mode data into a single image volume in the reference frame by incorporating the estimated motion transformations in the PET system matrix. We evaluated the performance of our approach in both phantom and human studies. Results: Visually, the motion-corrected (MC) PET images obtained using the proposed method have better quality and fewer motion artifacts than the images reconstructed without motion correction (NMC). Quantitative analysis indicates that MC yields higher myocardium to blood pool concentration ratios. MC also yields sharper myocardium than NMC. Conclusions: The proposed body motion correction method improves image quality of cardiac PET.

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Section: Discussionmentioning

confidence: 99%

Body motion detection and correction in cardiac PET: Phantom and human studies

et al. 2019

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“…Moreover, with the appearance of the CZT camera, it is possible to reuse an old tracer, 99m Tc-Teboroxime, which has a high extraction rate in a wide range of coronary blood flow rates and is seldom used because of its short half-life. However, it may show unique advantages in clinics with the progress of technology ( 40 ).…”

Section: Research Progress Of Imaging Methods For Detection Of Microvascular Angina Pectorismentioning

confidence: 99%

Research Progress of Imaging Methods for Detection of Microvascular Angina Pectoris in Diabetic Patients

Feng

et al. 2021

Front. Cardiovasc. Med.

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Diabetes is a complex metabolic disease characterized by hyperglycemia. Its complications are various, often involving the heart, brain, kidney, and other essential organs. At present, the number of diabetic patients in the world is growing day by day. The cardiovascular disease caused by diabetes has dramatically affected the quality of life of diabetic patients. It is the leading cause of death of diabetic patients. Diabetic patients often suffer from microvascular angina pectoris without obstructive coronary artery disease. Still, there are typical ECG ischemia and angina pectoris, that is, chest pain and dyspnea under exercise. Unlike obstructive coronary diseases, nitrate does not affect chest pain caused by coronary microvascular angina in most cases. With the increasing emphasis on diabetic microvascular angina, the need for accurate diagnosis of the disease is also increasing. We can use SPECT, PET, CMR, MCE, and other methods to evaluate coronary microvascular function. SPECT is commonly used in clinical practice, and PET is considered the gold standard for non-invasive detection of myocardial blood flow. This article mainly introduces the research progress of these imaging methods in detecting microvascular angina in diabetic patients.

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“…Non-invasive radionuclide physiologic scanning is an excellent example of the ongoing need for dedicated radiotracers, improved imaging technologies, and more advanced compartmental models to allow for a complete characterization of the metabolism. Some radionuclides are used to identify metabolisms, such as 123 I, 11 C, and 18 I for cardiac diagnostics [ 231 ] or Tau PET for Alzheimer’s disease diagnosis [ 232 ]. For oncology purposes, different cancer theranostic techniques have been developed in the four summaries.…”

Section: Impact To the Future Trend Of Radiopharmaceuticalsmentioning

confidence: 99%

The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker

et al. 2022

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Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators, whose characteristics are explained and can be used as a guide for the researcher.

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Radiopharmaceuticals for cardiac imaging: Current status and future trends

Cited by 7 publications

References 20 publications

Body motion detection and correction in cardiac PET: Phantom and human studies

Body motion detection and correction in cardiac PET: Phantom and human studies

Research Progress of Imaging Methods for Detection of Microvascular Angina Pectoris in Diabetic Patients

The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker

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