Radioprotective Effect of Hesperidin: A Systematic Review

Abstract

Background and objectives: Ionizing radiation (IR) has been of immense benefit to man, especially for medical purposes (diagnostic imaging and radiotherapy). However, the risks of toxicity in healthy normal cells, leading to cellular damage as well as early and late side effects, have been major drawbacks. The aim of this study was to evaluate the radioprotective effect of hesperidin against IR-induced damage. Materials and Methods: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were applied in reporting this study. A search was conducted using the electronic databases PubMed, Scopus, Embase, Google Scholar, and www.ClinicalTrials.gov for information about completed or ongoing clinical trials. Results: From our search results, 24 studies involving rats, mice, and cultured human and animal cells were included. An experimental case—control design was used in all studies. The studies showed that the administration of hesperidin reduced oxidative stress and inflammation in all investigated tissues. Furthermore, it increased 30-day and 60-day survival rates and protected against DNA damage. The best radioprotection was obtained when hesperidin was administered before irradiation. Conclusions: The results of the included studies support the antioxidant, anti-inflammatory, and antiapoptotic abilities of hesperidin as a potential radioprotective agent against IR-induced damage. We recommend future clinical trials for more insights.

Phenolic profile, antioxidant and enzyme inhibitory activity of the ethyl acetate, methanol and water extracts of Capparis spinosa L.

“…However, as mentioned above, the presence of hesperidin and hyperoside in this plant was brought to the literature for the first time with this study. There are some literature data on the contribution of these compounds to antioxidant activity with some other plants or with these compounds themselves (Ku et al, 2014;Hao et al, 2016;Yatao et al, 2018;Gao et al, 2019;He et al, 2019;Kim et al, 2019;Musa et al, 2019;Aggarwal et al, 2020;Huang et al, 2020). These findings support the correlation coefficient data obtained from the present study.…”

Targeting Jab1 using hesperidin (dietary phytocompound) for inducing apoptosis in HeLa cervical cancer cells

“…In this research, we have elucidated the mechanism involved behind the inhibitory potential of hesperidin against HeLa cancer cells via Jab1 mRNA down‐regulation. Hesperidin has displayed numerous anti‐inflammatory and anticancerous efficacies by inducing apoptosis in several carcinomas (Aggarwal et al., 2020; Hajialyaniet al, 2019; Musa et al., 2019). Moreover, hesperidin suppresses cell invasion and inhibits MMP expression and epithelial–mesenchymal transition (EMT) related proteins (Tabeshpour,et al., 2020; Yatao et al., 2018).…”

The role of hesperidin on healing an incised wound in an experimentally induced diabetic adult male albino rats. Histological and Immunohistochemical Study

“…Hyperplasia and proliferation of some hair follicles cells as a source of stem cells called follicular bulge was noticed in some sections (Figure 5). There were wide spaces (Figures 4, 8) and few blood capillaries in the dermis (Figures 4,8,10). In group IV, H & E picture revealed complete closure of the wounds in all sections.…”

“…Hesperidin (hesperetin-7-rhamnoglucoside) is a bioflavonoid found in citrus fruits such as tangerine, orange, and lemon as well as in plant extracts as tea and olive oil. The highest concentrations of hesperidin are present in citrus fruit peels [8] . Hesperidin has been stated to be antibacterial, antiviral, anti-inflammatory and analgesic in many studies [9] .…”