Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

Citrin, Deborah E.; Cotrim, Ana P.; Hyodo, Fuminori; Baum, Bruce J.; Krishna, Murali C.; Mitchell, James B.

doi:10.1634/theoncologist.2009-s104

Cited by 408 publications

(338 citation statements)

References 85 publications

(86 reference statements)

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“…Therefore, the focus has been shifted to the evaluation of the radioprotective potential of plants and herbs (Citrin et al, 2010;Pal et al, 2013), and compounds derived from them. This review attempts to evaluate the roles of fourteen (14) plant extracts or plant-derived compounds in mitigation of radiological effects.…”

Section: Lakhan Kmamentioning

confidence: 99%

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

Kma¹

2014

Asian Pacific Journal of Cancer Prevention

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Section: Lakhan Kmamentioning

confidence: 99%

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

Kma¹

2014

Asian Pacific Journal of Cancer Prevention

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“…[16] Many antioxidants have been shown to limit the toxicity of radiotherapy in animal models. [17] Here, Patil and colleagues investigated the radioprotective effect of two antioxidants, RUT and QRT, in mice.…”

Section: Spotlight On Original Articlesantioxidants Protect Against Dmentioning

confidence: 99%

“…Many hurdles remain, however, and clinical trials with antioxidants have produced mixed results. [17] A remaining challenge is to target the protective effects of antioxidants to normal tissues. The sulfhydryl compound amifostine, which is currently the only radioprotector compound in clinical use, does this quite well already, as it concentrates more rapidly in normal than in tumor cells.…”

Section: Spotlight On Original Articlesantioxidants Protect Against Dmentioning

confidence: 99%

Mysteries of the mighty microbiota

Walton¹

2014

Biomed J

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In this issue of the Biomedical Journal, we take a close look at the microbial metropolis of the gut and examine its impact on human health. We also highlight an interesting animal study showing that short-term treatment with antioxidants can protect tissues against the genotoxic effects of ionizing radiation. Such reports continue to fuel the hotly debated topic of the benefits of antioxidants. This issue also features several clinical studies examining the efficacy of current treatment regimens for primary breast lymphoma, Helicobacter pylori, and multidrug-resistant Acinetobacter baumannii. (Biomed J 2014;37:241-244)

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“…Sulfhydryl bond in the structure of l ‐cysteine ( l ‐Cys) allows it to act as a radio protector by scavenging free radicals 22, 23, 24. Experiments in rats demonstrated that animals administered l ‐Cys withstood normally lethal doses of X‐rays25 and showed considerably reduced damage to essential organs compared to untreated animals 26.…”

Section: Introductionmentioning

confidence: 99%

Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

Chou

Yuh

et al. 2017

Advanced Science

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Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off‐target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l‐cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ‐radiation. Presence of γ‐radiation significantly improves DOX release from the GC/DOX under acidic pH conditions, suggesting that GC dendrimer is a radiation‐sensitive drug delivery system. GC/DOX is further evaluated by determining cytotoxicity in uterine cervical carcinoma HeLa cells. GC/DOX shows high affinity for cancer cells and effective drug release following an external stimulus (radiation exposure), whereas an in vivo zebrafish study confirms that l‐cysteine acts as a radiosensitizer. GC/DOX treatment combined with radiotherapy synergistically and successfully inhibits cancer cell growth.

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Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

Abstract: The article reviews agents in clinical use or in development as radioprotectors and mitigators of radiation-induced normal tissue injury.

Cited by 408 publications

References 85 publications

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

Mysteries of the mighty microbiota

Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

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