Radioprotectors.org: an open database of known and predicted radioprotectors

Aliper, Alexander; Bozdaganyan, Marine E.; Sarkisova, Viktoria A.; Veviorsky, Alexander P; Ozerov, Ivan V.; Orekhov, Philipp; Korzinkin, Mikhail; Moskalev, Alexey; Zhavoronkov, Alex; Осипов, А. Н.

doi:10.18632/aging.103815

Cited by 21 publications

(8 citation statements)

References 104 publications

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“…The most fatal radiation-induced lesions are those of cellular membrane and nuclear genomic DNA. Radioprotective capabilities of the majority of currently used radioprotective compounds, such as indraline and aminothiols (4,5) , are based on their capabilities of inducing acute generalized hypoxia in radio-susceptible tissues, primarily in the bone marrow (6) . Other radioprotectors, such as IL-1 (21)(22)(23) , IL-8 (24,25) , thrombospondin- (26,27) and TLR-based preparations (28) , are known to preserve the hematopoietic stem cells, and their effect is also associated with the induction of local hypoxia in the bone marrow.…”

Section: Discussionmentioning

confidence: 99%

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Changes in the number and morphology of blood cells in mice pretreated with RNA preparations and exposed to 8 Gy of gamma radiation

Dubatolova

Ritter²,

Proskurina³

et al. 2022

Int J Radiat Res

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Background:In our recent studies, yeast double-stranded RNA showed radioprotective effect in mice exposed to 9.4 Gy of gamma radiation. The current work continues our inquiry and describes the changes in the number and morphology of blood cells in mice injected with double-stranded RNA from Saccharomyces cerevisiae prior to gamma irradiation. To be capable of estimating the required parameters, we have used 8 Gy of radiation, which allowed mice to survive for up to 37 days (LD60/30). Materials and Methods: Animals received single intravenous injections of one of the following compounds: (1) 7 mg of total RNA isolated from baking yeast Saccharomyces cerevisiae, (2) 200 μg of double-stranded RNA or (3) 400 μg of doublestranded RNA. 30 minutes later, using a 137 Cs gamma emitter, mice were irradiated with a dose of 8 Gy at the rate of 1.4 Gy/min. The radioprotective effect of preparations was assessed based on death rates. Results: Injections of both 200 μg of double-stranded RNA and 7 mg of total RNA prior to irradiation provided the best radioprotective effects, ensuring the survival of 100% of animals. Changes in the number of blood cells and their morphological aberrations were being monitored for 37 days after irradiation. Conclusion: The protection from lethal radiation doses is associated with the preservation and rapid recovery of leukocytic and erythroid lineages.

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Section: Discussionmentioning

confidence: 99%

“…Radioprotectors, both novel and employed in various branches of industry, are described in numerous reviews, handbooks, and manuals (1)(2)(3) . Nevertheless, the search for an efficient, relatively cheap and low-or non-toxic drug mitigating all manifestations of the acute radiation syndrome is still a challenge (4)(5)(6) .…”

Section: Introductionmentioning

confidence: 99%

Changes in the number and morphology of blood cells in mice pretreated with RNA preparations and exposed to 8 Gy of gamma radiation

Dubatolova

Ritter²,

Proskurina³

et al. 2022

Int J Radiat Res

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“…Furthermore, numerous radioprotectors that rely on selective uptake by normal organ tissues have been developed, with short and long-acting protectors successfully being utilized in modern practice [82]. Follow-up visits by patients and specific drug treatments are considered secondary preventative measures.…”

Section: Preventive Pharmacologic Therapies In Rihdmentioning

confidence: 99%

An overview of radiation-induced heart disease

et al. 2022

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Radiation therapy (RT) has dramatically improved cancer survival, leading to several inevitable complications. Unintentional irradiation of the heart can lead to radiation-induced heart disease (RIHD), including cardiomyopathy, pericarditis, coronary artery disease, valvular heart disease, and conduction system abnormalities. Furthermore, the development of RIHD is aggravated with the addition of chemotherapy. The screening, diagnosis, and follow-up for RIHD in patients who have undergone RT are described by the consensus guidelines from the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE). There is compelling evidence that chest RT can increase the risk of heart disease. Although the prevalence and severity of RIHD are likely to be reduced with modern RT techniques, the incidence of RIHD is expected to rise in cancer survivors who have been treated with old RT regimens. However, there remains a gap between guidelines and clinical practice. Currently, therapeutic modalities followed in the treatment of RIHD are similar to the non-irradiated population. Preventive measures mainly reduce the radiation dose and radiation volume of the heart. There is no concrete evidence to endorse the preventive role of statins, angiotensin-converting enzyme inhibitors, and antioxidants. This review summarizes the current evidence of RIHD subtypes and risk factors and suggests screening regimens, diagnosis, treatment, and preventive approaches.

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“…e therapy of acute radiation disease is a preparation based on chemical and biological substances [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Development of an Optimal Model of Combined Radiation and Biological Lesions

Gaynutdinov¹,

Vagin²,

Kurbangaleev³

et al. 2022

Veterinary Medicine International

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Since the search for the effective medication in combined lesions includes the selection of an optimal experimental model for such injuries, there is actually a study aimed at developing an optimal model of combined radiation-biology (Pasteurella) lesions. The pathogen Pasteurella multocida (as one of the most frequent pathogenic agents involved in both isolated and combined radiation-biology lesions of agricultural animals) was used as a model of a biological agent to reproduce experimental biological research. We employed the “Chinchilla” rabbits of 2.5–3.0 kg body weight as a biological model for doing combined radiation Pasteurella lesion. When determining the optimal model of combined radiation-biology (Pasteurella) lesion, we consider that in the joint action of various pathological agents on the organism, there is a synergistic effect of explosion agents, previously specifying minimal doses of external γ-radiation and pasteurellosis pathogen that in the joint action of nonfatal doses would be lethal. The first stage of the experiments determined the minimal doses of gamma rays and pasteurellosis pathogen that in joint action causes combined radiation-biology pathology. We examined 66 rabbits divided into 11 groups of 6 animals each to determine minimal doses of infectious agent-pasteurellosis pathogen. The animals of the first 9 groups were given subcutaneously Pasteurella species at doses 1·109, 1·108, 1·107, 1·106, 1·105, 1·104, 1·103, 1·102, and 1·101 of microbial cells per animal of 0.3 ml suspension in volume; the 10th group of animals were given saline solution; the 11th served as a biological control group. In determining the minimal doses of gamma rays, we conducted experimental tests on 36 rabbits, which have been exposed to external γ-radiation in the “PUMA” system with a 137Cs radiation source of the exposure dose of 5.38 R/min at doses 2.0, 4.0, 6.0, 8.0, 10, and 12 Gy. To specify the optimal model of radiation-pasteurellosis lesion, we used the rabbits subjected to a combined radiation-biology effect using minimal doses of gamma rays and pasteurellosis agent, leading to a lethal effect during their complex action. The researches revealed that 50% of the death of rabbits infected with pasteurellosis occurs using Pasteurella at a dose of 3.7·104 microbial cells per kilogram (LD50 = 3.7∙104 m.c./kg), and 50% of radiation death in rabbits occurs when irradiated their gamma rays at a dose of 8.0 Gy (LD50 = 8.0 Gy). The combined effect of nonlethal doses of the studied agents in the indicated doses on rabbits led to the aggravation of the course of radiation and pasteurellosis infection, causing the death of animals from combined radiation-pasteurellosis pathology. The model combined radiation-pasteurellosis disease ran its course rapidly, and the animals died 3 to 6 days after the onset. The autopsy of the animals that died from acute radiation-pasteurellosis pathogen had found swelling of the subcutaneous tissue in the pharynx and intermaxillary space of the neck, hyperemia, lymphoid nodular hyperplasia, numerous hemorrhages on the serous and mucous membranes and in the tissues of the parenchymal organs, serous or serous-fibrinous exudate, and in the chest and abdominal regions, pulmonary edema. The research stated that gamma radiation of rabbits at a dose of 8.0 Gy conducted before exposure with Pasteurella at LD50 (3.7·104 m.c./kg) declined the course of the pasteurellosis process, facilitated its generalization, and fastened the death of animals. Combined radiation-pasteurellosis infection ran its course rapidly, and the animals died within 3 to 6 days after the onset of the disease. The autopsy showed the pathologicoanatomic factors of the acute pasteurellosis: swelling of the subcutaneous tissue, purulent-catarrhal bronchopneumonitis, and pulmonary edema.

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Radioprotectors.org: an open database of known and predicted radioprotectors

Cited by 21 publications

References 104 publications

Changes in the number and morphology of blood cells in mice pretreated with RNA preparations and exposed to 8 Gy of gamma radiation

Changes in the number and morphology of blood cells in mice pretreated with RNA preparations and exposed to 8 Gy of gamma radiation

An overview of radiation-induced heart disease

Development of an Optimal Model of Combined Radiation and Biological Lesions

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