Radiosensitive effect of curcumin on thyroid cancer cell death induced by radioiodine-131

Hosseinimehr, Seyed Jalal; Hosseini, S. Amir

doi:10.2478/intox-2014-0011

Cited by 16 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Curcumin could selectively sensitize thyroid cancer cells to death induced by radioactive iodine without any toxicity on nonmalignant fibroblast cells. 13 In the present study, we showed that curcumin significantly protected human healthy lymphocytes from genotoxicity induced by external IR. These results showed curcumin has a radioprotective effect on normal cells and a radiosensitizing effect on cancer cells, and so is promising for use as a natural agent in cancer therapy.…”

Section: Discussionsupporting

confidence: 54%

“…The curcumin concentrations were selected based on previous studies. 5,13 Piperine concentration was selected based on previous studies that showed P has a IC 50 of 61 µg/mL on the HeLa cell line 14 and it did not exhibit any genotoxicity or cellular toxicity up to 60 µM (17 µg/mL). 15 Control samples were treated with diluted DMSO in RPMI at the same concentration as the other curcumin and/or piperine samples.…”

Section: Blood Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

The Influence of Piperine on the Radioprotective Effect of Curcumin in Irradiated Human Lymphocytes

Ghelishli

Ghasemi

Hosseinimehr

2019

tjps

Self Cite

View full text Add to dashboard Cite

İyonize radyasyon (IR) normal hücrelerde DNA hasarına neden olarak genotoksisiteye neden olur. Curcumin ve piperin ile ortak tedavinin insan normal lenfositlerinde iyonlaştırıcı radyasyonun neden olduğu genotoksisiteye karşı koruyucu etkileri araştırıldı. Gereç ve Yöntemler: İnsan kan numuneleri, farklı konsantrasyonlarda (5, 10 ve 25 µg/mL) kurkumin ve/veya (2.5 µg/mL) piperin içerisinde ile ön muamele edildi ve daha sonra 1.5 Gy'lik bir dozda IR'ye maruz bırakıldı. Curcumin ve piperinin radyo-koruyucu etkileri mikronükleus (MN) testi ile değerlendirildi. Bulgular: Kurkumin ve piperin, lenfositlerde IR tarafından indüklenen MN yüzdesini azaltmıştır. Sadece piperin, tüm konsantrasyonlarda tek başına uygulanan kurkumin ile karşılaştırıldığında, IR tarafından indüklenen genotoksisiteyi önemli ölçüde azaltmıştır. Düşük konsantrasyonda 5 µg/mL'de piperin ve kurkumin kombinasyonu ile ilave bir radyo-koruyucu etki gözlenirken, bu sinerjistik etki 10 ila 25 µg/mL'lik yüksek konsantrasyonlarda kurkuminle gözlenmedi. Sonuç: Piperin, kurkuminle karşılaştırıldığında düşük konsantrasyonda güçlü bir radyo-koruyucu etkiye sahiptir. Bununla birlikte, düşük konsantrasyonda piperin ve kurkumin ile birlikte yapılan muamele ile ilave bir radyo-koruyucu etki gözlenirken, piperin yüksek konsantrasyonda kurkumin ile birlikte muamele edildiğinde normal lenfositlerde MN oranını artırmıştır. Anahtar kelimeler: Kurkumin, piperin, radyo-koruyucu genotoksisite, iyonize radyasyon ÖZ Objectives: Ionizing radiation (IR) induces DNA damage in normal cells, leading to genotoxicity. The radioprotective effects of co-treatment with curcumin and piperine were investigated against genotoxicity induced by IR in human normal lymphocytes. Materials and Methods: Human blood samples were pretreated with curcumin at different concentrations (5, 10, and 25 µg/mL) and/or piperine (2.5 µg/mL) and then were exposed to IR at a dose 1.5 Gy. The radioprotective effects of curcumin and piperine were assessed by micronucleus (MN) assay. Results: Curcumin and piperine reduced the percentage of MN induced by IR in lymphocytes. Piperine alone significantly reduced genotoxicity induced by IR as compared to curcumin alone at all concentrations. An additive radioprotective effect was observed with combination of piperine and curcumin at the low concentration of 5 µg/mL, while this synergistic effect was not observed with curcumin at the higher concentrations of 10 and 25 µg/mL. Conclusion: Piperine has a potent radioprotective effect at low concentration as compare to curcumin. However, an additive radioprotective effect was observed with co-treatment with piperine and curcumin at low concentration, while piperine increased the percentage of MN in normal lymphocytes when co-treated with curcumin at higher concentration.

show abstract

Section: Discussionsupporting

confidence: 54%

Section: Blood Treatmentmentioning

confidence: 99%

The Influence of Piperine on the Radioprotective Effect of Curcumin in Irradiated Human Lymphocytes

Ghelishli

Ghasemi

Hosseinimehr

2019

tjps

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several studies demonstrated that antioxidants have radioprotective effects on normal cells by mainly decreases ROS levels while these compounds have radiosensitive effects in tumor cells by increasing ROS levels. Curcumin as a powerful antioxidant has radioprotective effect on normal cells [30], while it has radiosensitizing effect in tumor cells by increasing ROS level and suppressing inflammatory process such as NF-κΒ activation pathway induced by ionizing radiation [31][32][33]. Genestein has antioxidant activity and protect healthy cell against toxicity induced by IR [34,35].…”

Section: Discussionmentioning

confidence: 99%

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

Azizi¹,

Ghasemi²,

Asgarian-Omran³

et al. 2018

mpj

View full text Add to dashboard Cite

Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation (IR) still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles (CNPs) on non-small lung cancer (A-549) cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.

show abstract

“…Recently we showed that curcumin had protective effect against genotoxicity induced by iodine radioactive in human lymphocyte 5 . Curcumin could sensitize selectively thyroid cancer cell to death induced by iodine radioactive without any toxicity on non-malignant fibroblast cells 13 . In the present study, we showed that curcumin significantly protected human healthy lymphocyte against genotoxicity induced by external IR.…”

Section: Discussionmentioning

confidence: 99%

“…The twelve samples groups are following: control, ionizing radiation (IR), 5 µg/ml CUR+IR, 10 µg/ml CUR+IR, 25 µg/ml CUR+IR, 5 µg/ml CUR+2.5 µg/ml(P)+IR, 10 µg/ml CUR+2.5 µg/ml(P)+IR, 25 µg/ml CUR+2.5 µg/ml(P)+IR, 2.5 µg/ml(P)+IR, 25 µg/ml CUR, 2.5 µg/ml(P), 5 µg/ml CUR+2.5 µg/ml(P). The curcumin concentrations were selected based on previous studies 5, 13 . Piperine concertation was selected based on previous studies that P has a IC50 61 µg/ml on HeLa cell line 14 and it did not exhibited any genotoxicity and cellular toxicity up to 60 µM (17 µg/ml) 15 .…”

Section: Blood Treatmentmentioning

confidence: 99%

The influence of piperine on radioprotective effect of curcumin in irradiated human lymphocytes

Gheleshli¹,

Ghasemi²,

Hosseinimehr³

2018

tjps

Self Cite

View full text Add to dashboard Cite

Objective: Ionizing radiation (IR) induces DNA damage on normal cell leads to genotoxicity. The radioprotective effects of co-treatment curcumin and piperine were investigated against genotoxicity induced by ionizing radiation in human normal lymphocytes. Material and methods: Human blood samples were pretreated with curcumin at different concentrations (5, 10 and 25 µg/ml) and/or piperine (2.5 µg/ml) and then were exposed to IR at dose 1.5 Gy. The radioprotective effects of curcumin and piperine were assessed by micronucleus (MN) assay. Results: It was found that curcumin and piperine reduced the percentage of MN induced by IR in lymphocytes. Piperine alone significantly reduced genotoxicity induced by IR as compared to curcumin alone at all concentrations. An additive radioprotective effect was observed in combination of piperine and curcumin at low concentration 5 µg/ml while this synergistic effects were not observed with curcumin at higher concentrations 10 and 25 µg/ml. Conclusion: This result provides that piperine acts as a potent radioprotective effect at low concentration as compare to curcumin. However, an additive radioprotective effect was observed with co-treatment piperine and curcumin at low concentration, while piperine increased the percentage of MN in normal lymphocytes when was co-treated with curcumin at higher concentration.

show abstract

Radiosensitive effect of curcumin on thyroid cancer cell death induced by radioiodine-131

Cited by 16 publications

References 19 publications

The Influence of Piperine on the Radioprotective Effect of Curcumin in Irradiated Human Lymphocytes

The Influence of Piperine on the Radioprotective Effect of Curcumin in Irradiated Human Lymphocytes

Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation

The influence of piperine on radioprotective effect of curcumin in irradiated human lymphocytes

Contact Info

Product

Resources

About