Radiotherapy Can Cause Haemostasis in Bleeding Skin Malignancies

Jang, Helena Sung-In; Spillane, Andrew J.; Boyle, Frances; Fogarty, Gerald B

doi:10.1155/2012/168681

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…Bleeding complications typically arise in patients with advanced cancer, with 10% experiencing at least one episode of bleeding [ 21 , 22 ]. Bleeding from cancer, such as local tumor invasion, irregular vasculature of the tumor, tumor regression, or systemic coagulopathy, is induced by paraneoplastic syndrome [ 22 , 23 ]. Bleeding in cancer patients may be worsened by the use of immunotherapy, nonsteroidal anti-inflammatory drugs (NSAIDs), and anticoagulants.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with advanced malignancy, multiple modalities are conventionally used to control hemorrhage, as reviewed by Pereira and Phan, including hemostatic agents, endoscopy, vessel ligation, cauterization, tissue resection, transcutaneous arterial embolization, balloons placements, and radiotherapy. Blood products, vasopressin, antifibrinolytic agents, and somatostatin analogs are also systemic therapies [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tumor bleeding can also be caused by vascular damage due to local tumor invasion or systemic coagulopathy due to paraneoplastic syndrome. RT may not, however, prevent bleeding of normal vessels that are invaded by cancers, such as carotid blowouts in progressive malignancy of the head and neck [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…The pathophysiology of the cancer radiation effect causes significant damage to DNA by inducing malignant damage to endothelial cells, causing signal transduction pathway activation and leading to cell apoptosis [ 23 ]. Radiotherapy was shown to have an effect within 24−48 hours of the first dose.…”

Section: Discussionmentioning

confidence: 99%

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Forequarter amputation post transarterial chemoembolization and radiation in synovial sarcoma: A case report

Yulian

Pandelaki

Kodrat

et al. 2021

International Journal of Surgery Case Reports

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Highlights Forequarter Amputation is a safe and feasible option for patients with soft tissue malignancy like synovial sarcoma. Forequarter Amputation has a beneficial impact on the patient’s psychological and functional integrity. Transarterial Chemoembolization and radiotherapy can be the treatment option for the patient with malignant bleeding. TACE and radiotherapy are effective in controlling the pre-operative and intraoperative bleeding of forequarter amputation. The TACE procedure aimed to control bleeding, strengthen local surgical control and decrease the morbidity of wide excisions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Forequarter amputation post transarterial chemoembolization and radiation in synovial sarcoma: A case report

Yulian

Pandelaki

Kodrat

et al. 2021

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

show abstract

“…Pain and mass effect can be treated with RT. Hemorrhage can be controlled by low dose RT . Skin lesions can be treated with many modalities, but RT is an option that should not be overlooked .…”

Section: Palliative Radiation Therapymentioning

confidence: 99%

Radiation therapy for advanced and metastatic melanoma

Fogarty

Hong

2013

Journal of Surgical Oncology

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Radiation therapy (RT) is an important modality in cancer treatment. However, the general perception is that melanoma is radio-resistant. High quality clinical trials are helping to establish the place of RT in select scenarios of advanced disease at primary, regional, and distant sites. New RT techniques need to be integrated with effective new systemic therapies within a multidisciplinary environment to ensure optimum patient outcomes. It is important that radiation oncologists embrace this opportunity.

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Metastatic Melanoma to the Small Bowel and Colon: A Systematic Review of the Global Experience and Institutional Cohort Analysis Detailing a Rare Clinical Entity

Yee,

Thielen,

Truong

et al. 2024

Journal of Surgical Oncology

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IntroductionCutaneous melanoma is among the most common solid tumors to metastasize to the gastrointestinal (GI) tract. Literature summarizing the clinical experience and features of this unique pathology is lacking.MethodsA systematic review of the available literature reporting clinically salient features of melanoma metastases to the small and large intestines was conducted. Additionally, we surveyed our institutional experience of surgically treated melanoma metastasis to the small bowel and colon. A descriptive analysis was performed. Kaplan–Meier curves with log‐rank tests were used to analyze time‐to‐event intervals. Univariable and multivariable Cox logistic regression models were generated to identify predictors of survival.ResultsOver 100 studies including 1153 patients were included. GI metastases predominantly affected males, were in the small bowel/jejunum, equally presented as solitary and multiple lesions, and were generally not the first site of distant metastatic disease. The median time from primary lesion diagnosis to GI metastasis was 48 months. Analysis of our institutional cohort suggested that survival in patients receiving complete GI‐specific surgical resection and immune checkpoint inhibitors (ICIs) was prolonged compared to palliative resection and without ICI therapy. Positive prognostic factors for survival following GI metastasis included fewer GI metastatic lesions, complete resection, and longer duration between primary tumor diagnosis and GI metastasis.ConclusionsGI metastases are a sign of advanced metastatic melanoma. Clinical suspicion of metastatic involvement in patients with a history of melanoma who develop any abdominal symptoms or anemia should remain high. Receipt of complete surgical resection and ICIs may prolong survival in disseminated melanoma.

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Radiotherapy Can Cause Haemostasis in Bleeding Skin Malignancies

Cited by 5 publications

References 10 publications

Forequarter amputation post transarterial chemoembolization and radiation in synovial sarcoma: A case report

Forequarter amputation post transarterial chemoembolization and radiation in synovial sarcoma: A case report

Radiation therapy for advanced and metastatic melanoma

Metastatic Melanoma to the Small Bowel and Colon: A Systematic Review of the Global Experience and Institutional Cohort Analysis Detailing a Rare Clinical Entity

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