Radiotherapy for canine chronic superficial keratitis using soft X-rays (15 kV)

Allgoewer, Ingrid; Hoecht, Stefan

doi:10.1111/j.1463-5224.2009.00750.x

Cited by 11 publications

(8 citation statements)

References 8 publications

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“…In mildly affected cases this can be achieved by topical application of corticosteroids alone or in combination with cyclosporine A 17,18 . Additionally, a number of more invasive therapeutic approaches including superficial keratectomy, radiotherapy 19 or cryosurgery 20 have been used in cases that are non‐responsive to topical immunosuppressive therapy.…”

Section: Introductionmentioning

confidence: 99%

The effect of UV‐blocking contact lenses as a therapy for canine chronic superficial keratitis

Denk

Fritsche

Reese

2011

Veterinary Ophthalmology

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Section: Introductionmentioning

confidence: 99%

The effect of UV‐blocking contact lenses as a therapy for canine chronic superficial keratitis

Denk

Fritsche

Reese

2011

Veterinary Ophthalmology

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“…A significant decrease in corneal vascularization was also achieved with tacrolimus and dimethyl sulfoxide (DMSO) ophthalmic drops (4), but the long-term clinical evolution of vascular lesions is still unknown. Soft X-ray therapy caused a similar decrease in vascularization, that was maintained for 24 weeks after completion of the procedure in most eyes (1). Despite this, no data on the evolution of vascular lesions beyond this period is yet available.…”

Section: Discussionmentioning

confidence: 91%

“…Ophthalmic examination and assessment of the corneal lesions: Each patient underwent direct (Heine ® Beta 200) and indirect (Heine ® Omega 500) ophthalmoscopy, fluorescein staining (Fluoro Touch), Schirmer tear test (Tear Touch Blu) and intraocular pressure measurement (Tono-Pen ® , Reichert). The cornea was schematically divided into 24 sectors to assess corneal pigmentation (1,12), and each sector was graded in terms of melanic pigmentation extent. Corneal vascularization and edema were quantified each, by using a specific four grade scale, as presented in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Long-term prospective assessment of subconjunctival triamcinolone acetonide in addition to topical therapy in the management of chronic superficial keratitis

Beteg

Lelescu²,

Urda-Cîmpean

et al. 2020

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Chronic superficial keratitis (CSK) is a progressive inflammatory disease in adult dogs, associated with corneal vascular proliferation, edema and melanic pigment deposition. In the absence of a curative therapy, the current approach for the management of CSK aims to control disease progression and eventually decrease the severity of corneal lesions. Subconjunctival injections of corticosteroids may be effective in severe cases, where topical therapy alone is inadequate. The aim of this study was to comprehensively evaluate the effectiveness of subconjunctival triamcinolone acetonide (TA) injection in addition to topical steroid treatment for the long-term management of CSK, in dogs unresponsive to conventional topical steroids. Treatment efficacy was assessed in 11 dogs with bilateral CSK by periodic evaluation of the cornea in terms of vascularization, edema and pigmentation for up to 120 weeks. Clinically significant reductions in corneal pigmentation (P<0.0001), vascularization (P<0.0001) and edema scores (P<0.0001) were achieved during therapy. The greatest reduction was exhibited by corneal edema, closely followed by vascularization. Corneal pigmentation was less responsive and complete regression has not been achieved in any of the dogs. Severely affected corneas exhibited greater improvements in terms of pigmentation, whereas moderately affected corneas showed a slight decrease. Corneal edema and vascularization were adequately controlled, whereas corneal pigmentation exhibited a lower decrease in severity and was more difficult to manage on a long-term basis. This study suggests that subconjunctival injection of TA in addition to topical steroids could represent an effective option for long-term management of CSK in dogs unresponsive to topical steroids alone.

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“…Thus, efforts are being made to develop alternative therapies to inhibit the immune response and chronic in ammatory processes in order to reduce the suffering of animals with CSK and the need for their long periods of care. Many experimental tests have been done with therapies including contact lenses (13), radiotherapy with surgical procedures (14), and immunosuppressive drugs (2,(15)(16)(17). Recently, the use of tacrolimus and/or cyclosporine has been considered to be the therapy of choice.…”

Section: Introductionmentioning

confidence: 99%

Subconjunctival Use of Allogeneic Mesenchymal Stem Cells to Treat Chronic Superficial Keratitis in German Shepherd Dogs: Pilot Study.

Pereira

Bittencourt

Barros

et al. 2020

Preprint

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Background: Chronic superficial keratitis (CSK) is an ocular condition in dogs characterized by corneal opacification leading to visual function impairment. The aim of this study was to evaluate the clinical effect of allogeneic mesenchymal stem cells (MSC) of adipose tissue in dogs with CSK.Results: The conventional treatment group received topical Prednisolone 1% and the experimental group received MSC on the order of 1x106 were injected via subconjunctival in the peri-limbal region at 0 and 30 days. The animals were followed for 110 days to monitor the clinical progression and the statistical analysis was performed. Comparison of initial and final images revealed that areas with neovascularization and inflammatory infiltrate regressed in most eyes in both the conventional and experimental groups at the end of the 110 days. The experimental group responded positively to MSC treatment, but bellow the response achieved by the conventional group. Some areas of opacity of the cornea become transparent after transplantation of MSC. No local or systemic side effects were observed.Conclusions: Stem cells treatment produced clinical improvement in patients with CSK after 110 days without use of any drug combination and any local or systemic side effects, even if the improvement obtained was less than that seen with conventional corticosteroid therapy.

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Radiotherapy for canine chronic superficial keratitis using soft X-rays (15 kV)

Abstract: Soft X-ray irradiation combined with keratectomy is a safe and effective new treatment option for severe and advanced CSK with significant visual impairment due to corneal pathology.

Cited by 11 publications

References 8 publications

The effect of UV‐blocking contact lenses as a therapy for canine chronic superficial keratitis

The effect of UV‐blocking contact lenses as a therapy for canine chronic superficial keratitis

Long-term prospective assessment of subconjunctival triamcinolone acetonide in addition to topical therapy in the management of chronic superficial keratitis

Subconjunctival Use of Allogeneic Mesenchymal Stem Cells to Treat Chronic Superficial Keratitis in German Shepherd Dogs: Pilot Study.

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