Radiotherapy for extramammary Paget disease of the anogenital region

Dilmé-Carreras, Elisabet; Iglesias‐Sancho, Maribel; Márquez-Balbás, Gemma; Sola-Ortigosa, Joaquin; Umbert-Millet, P.

doi:10.1016/j.jaad.2009.11.689

Cited by 17 publications

(18 citation statements)

References 11 publications

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“…Radiation treatment was administered using an electron beam of 6 MeV, 2 Gy/d, 5 d/wk for 6 weeks until a total dose of 60 Gy was completed. Neither local recurrences nor internal malignancies were documented over a 2‐yearfollow‐up period . An 80‐year‐old woman with PPD treated with radiotherapy with curative intent was described, and the author concluded that radiotherapy is a viable treatment option with curative potential for patients with PPD .…”

Section: Radiotherapymentioning

confidence: 99%

Extramammary Paget's Disease of the Perianal Region: A Review of the Literature Emphasizing Management

Bie

Wei

Tasleem

2013

Dermatologic Surgery

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Surgery is the mainstay of treatment. Some noninvasive therapeutic modalities were also reported to be effective, such as photodynamic therapy, imiquimod, radiotherapy, chemotherapy, anti-androgen therapy, and carbon dioxide. Management of perianal Paget's disease remains difficult, and large controlled, multicentric studies should be performed to compare the effectiveness of current therapeutic modalities.

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Section: Radiotherapymentioning

confidence: 99%

Extramammary Paget's Disease of the Perianal Region: A Review of the Literature Emphasizing Management

Bie

Wei

Tasleem

2013

Dermatologic Surgery

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“…[35][36][37] Also the use of topical 5FU, retinoic acid, imiquimod 5% cream alone or in combination and of photodynamic therapy is described. [38,39] An interesting suggestion was made by Perrotto regarding the use of trastuzumab as a possible option because of overexpression of HER-2/neu in primary PPD.…”

Section: Discussionmentioning

confidence: 99%

Perianal Paget’s disease: case report and review of the literature

Bontinck

Rondou³

et al. 2016

Acta Chirurgica Belgica

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A peri-anal skin lesion, often eczema-like and with symptoms of pruritus, that does not resolve after classical local therapy should be biopsied. We present a case of peri-anal extramammary Paget's disease (EMDP) and associated anal adenocarcinoma. Reviewing the literature, more than 30% of patients with EMDP present a second primary tumour in their past, present or future history. In Europe, the risk of developing a new primary tumour in patients with this condition is increased compared with the standard population. In cases of peri-anal Paget's disease (PPD), specific histochemical markers allow us to differentiate between a primary and a secondary form, the secondary one is strongly associated with colorectal and anal tumours. We provide information about the most commonly suggested therapy for PPD with or without associated malignancy and about the recommended follow-up.

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“…Many patients who underwent radiotherapy achieved complete response [15,16,17,18,19,21,22,24,25,26,27,28,29]. Summarizing the data from 66 patients from the literature, the local progression-free survival at 5 years was 85%.…”

Section: Discussionmentioning

confidence: 99%

“…This data was collected by searching English-language journals included in the PubMed database and published between 1991 and 2012, using the keywords ‘EMPD' and ‘radiotherapy'. 15 available articles were identified [15,16,17,18,19,20,21,22,24,25,26,27,28,29,30]; however, 1 article [30] was excluded from this analysis because the applied radiotherapy methods were not described in detail. Therefore, 66 patients (21 male, 45 female; median age 73 years (range 38-92 years)) from 14 articles were analyzed (table 3).…”

Section: Methodsmentioning

confidence: 99%

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Radiotherapy in Patients with Extramammary Paget's Disease - Our Own Experience and Review of the Literature

et al. 2014

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Background: There are few reports on radiotherapy methods for treating extramammary Paget's disease (EMPD). The aim of this study was to explore the outcome of radiotherapy for EMPD. Patients and Methods: Between June 1995 and October 2010, 14 patients with EMPD (7 male and 7 female; median age 77 years) underwent radiotherapy at the Tokyo Medical University Hospital. The median total irradiation dose was 50 Gy, delivered in 20-33 fractions. Case reports of patients with EMPD were obtained from the PubMed database for the period of 1991-2012. 66 patients (median age 73 years) were identified. Radiotherapy outcomes were analyzed. Results: All patients achieved complete response within the irradiated volume during a median observation period of 71.4 months. The 5-year locoregional progression-free survival and overall survival were 91.7% (95% confidence interval (CI) 53.9-98.8%) and 84.3% (95% CI 50.3-95.8%), respectively. From the PubMed database, the 5-year local progression-free survival and locoregional progression-free survival were 84.5% (95% CI 65.3-93.6%) and 77.5% (95% CI 57.3-89.0%), respectively. 12 (18%) patients had a recurrence in the inguinal lymph nodes. Conclusion: Radiotherapy yielded good local control and survival, which suggests that it was effective for patients with EMPD and in particular medically inoperable EMPD.

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Radiotherapy for extramammary Paget disease of the anogenital region

Cited by 17 publications

References 11 publications

Extramammary Paget's Disease of the Perianal Region: A Review of the Literature Emphasizing Management

Extramammary Paget's Disease of the Perianal Region: A Review of the Literature Emphasizing Management

Perianal Paget’s disease: case report and review of the literature

Radiotherapy in Patients with Extramammary Paget's Disease - Our Own Experience and Review of the Literature

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