Radiotherapy in soft tissue sacoma of the extremities

Ngan, Samuel Y

doi:10.1080/17453674.1997.11744714

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…14 The optimal total tumor dose and fractionation scheme for canine STS has not been determined. Results from human studies 5,16,18 and limited canine studies 4 indicate that STS require cumulative doses in excess of 50 Gy. In the study reported herein, the majority of the dogs (n ϭ 19) received 57 Gy in 3-Gy fractions on a Monday through Friday schedule and had an overall median survival rate of 5.1 years.…”

Section: Discussionmentioning

confidence: 99%

“…27 Generally, preoperative radiotherapy is reserved for initially inoperable tumors as an alternative to radical surgery. 5,27 The role of chemotherapy in the treatment of STS remains investigational. 18,23 In veterinary medicine the reports of chemotherapy for STS, either for primary tumors or metastatic disease, are sparse.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 Treatment in the veterinary literature has included surgery alone, 6,7 chemotherapy, 8,9 radiation therapy, 4 or combination therapies. [10][11][12][13][14][15] When total tumor doses of 45 and 50 Gy were used to treat bulky STS, 1-year control rates of 48% and 67%, respectively, were obtained.…”

mentioning

confidence: 99%

“…13,14 Moderate doses of radiation (60-65 Gy) in combination with surgery resulted in improved response rates of STS. 5,14,16 Current opinion in human oncology is that similar local control and survival rates are attained with a better functional and cosmetic outcome by performing marginal surgical excision plus adjuvant radiotherapy compared to radical surgery alone. 5,[16][17][18][19] The purpose of this retrospective study was to evaluate response of dogs with marginally excised STS to adjuvant radiotherapy.…”

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confidence: 99%

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Postoperative Radiotherapy for Canine Soft Tissue Sarcoma

Forrest

Chun

Adams

et al. 2000

Veterinary Internal Medicne

112

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Thirty-five dogs with 37 soft tissue sarcoma tumors that were incompletely excised and treated with radiotherapy in the postoperative, adjuvant setting were reviewed. Variables evaluated included age, sex, tumor site, tumor histology, total tumor radiation dose, radiotherapy field size, time to recurrence, and survival. The majority of tumors were fibrosarcomas and hemangiopericytomas, but small numbers of other tumor types were also represented. Total tumor radiation dose ranged from 42 to 57 Gy given in 3-to 4.2-Gy daily fractions on a Monday through Friday schedule. Overall median survival was 1,851 days. Median time to local recurrence was greater than 798 days. Soft-tissue sarcoma tumors at oral sites had a statistically significant lower median survival (540 days) as compared to other tumor sites (2,270 days). Radiotherapy may be a useful adjuvant therapy for incompletely excised soft-tissue sarcomas with a reasonable expectation for long-term patient survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Postoperative Radiotherapy for Canine Soft Tissue Sarcoma

Forrest

Chun

Adams

et al. 2000

Veterinary Internal Medicne

112

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“…Prior to the use of combined therapy, radical resection of entire limb muscle compartments or proximal extremity amputation was the accepted standard treatment for soft tissue sarcoma. However, current protocols employing irradiation and conservative tumor resection permit the preservation of functional tissue, while maintaining local tumor control rates equal to or better than radical surgery alone [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Intradermal Injection of Autologous Dermal Fibroblasts Improves Wound Healing in Irradiated Skin

Ferguson

Boynton

Wunder

et al. 1999

Journal of Surgical Research

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Primary multidisciplinary management of extremity soft tissue sarcomas

Clarkson¹,

Ferguson

2004

Curr. Treat. Options in Oncol.

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Soft tissue sarcomas (STS) are a rare and heterogeneous group of malignancies that most commonly present as large painless masses deep in the muscular compartments of the extremities. Investigation and treatment of these patients must be undertaken at a tertiary referral unit. Staging studies must include a high-quality magnetic resonance imaging (MRI) scan of the local site and a computed tomography (CT) scan of the chest to investigate for possible metastatic disease. Review of biopsy material must be undertaken by an experienced musculoskeletal pathologist. Currently, histologic diagnosis and grade are assigned to the tumor, but in tumors such as synovial sarcoma and Ewing's family of tumors, molecular evaluation is becoming crucial for diagnostic, prognostic, and therapeutic reasons. Surgical resection of sarcomas with negative surgical margins remains the mainstay of treatment. Surgical treatment alone is indicated for small superficial masses that are not adjacent to bone or neurovascular structures. However, in large deep masses where surgical margins are likely to be close in order to preserve important neurovascular structures and bone, combined treatment using surgical resection and radiation results in acceptable local control rates and reasonable patient function. It is incumbent on the management team to decide on timing of radiotherapy as a practice. This decision is based on several factors but potential complications must be taken into account. In this regard the long-term effects on normal tissues must be considered. Functional outcome has become an essential consideration when recommending treatment. If promising techniques become available to reduce the incidence of wound complications or to decrease the dose of radiation to normal tissue, preoperative radiation should be considered in light of its lower incidence of long-term effects that result in reduction in patient function.

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Radiotherapy in soft tissue sacoma of the extremities

Cited by 16 publications

References 30 publications

Postoperative Radiotherapy for Canine Soft Tissue Sarcoma

Postoperative Radiotherapy for Canine Soft Tissue Sarcoma

Intradermal Injection of Autologous Dermal Fibroblasts Improves Wound Healing in Irradiated Skin

Primary multidisciplinary management of extremity soft tissue sarcomas

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