Radiozinc studies in experimental wound healing

Savlov, Edwin D.; Strain, William H.; Huegin, Felix

doi:10.1016/s0022-4804(62)80065-1

Cited by 108 publications

(37 citation statements)

References 4 publications

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“…The more the zinc level decreases, the more mitotic activity decreases, and then scar maturation occurs. [27][28][29] Topical application of zinc decreases the rate of debris and necrotic material and increases the epithelization. [30][31][32][33] According to Kietzmann, [35] locally applied zinc accelerates the healing of ulcerated skin.…”

Section: Discussionmentioning

confidence: 99%

Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study

Arslan¹,

Karahan²,

Okuş³

et al. 2012

Ulus Travma Acil Cerrahi Derg

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Section: Discussionmentioning

confidence: 99%

Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study

Arslan¹,

Karahan²,

Okuş³

et al. 2012

Ulus Travma Acil Cerrahi Derg

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“…Zinc has been shown to modulate the body's immune response [5,6]. In particular, zinc increases the activation and proliferation of lymphocytes, mainly T and natural killer (NK) cells, and stimulates cellular defense mechanisms [6][7][8]. The immunomodulatory effect of zinc also results in an increase in the activity of thymocytes, macrophages, and heterophils, as well as increased antibody production, which enhances the potential of the humoral response [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Zinc Sulfate and Zinc Glycine Chelate on Concentrations of Acute Phase Proteins in Chicken Serum and Liver Tissue

Jarosz

Marek

Grądzki

et al. 2018

Biol Trace Elem Res

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The aim of the study was to determine how inorganic and organic forms of zinc affect the concentrations of C-reactive protein (CRP), serum amyloid A (SAA), alpha-1-acid glycoprotein (α-1-AGP), haptoglobin (Hp), and transferrin (TRF) in the blood and liver tissue of 450 1-day-old Ross 308 chicken. Four experimental groups received one the following: inorganic zinc (ZnSO 4 ), a zinc phytase enzyme supplement (ZnSO 4 -F), organic zinc in combination with glycine (Zn-Gly), or organic zinc supplemented with phytase (Zn-Gly-F). The chicken serum and liver homogenates were assayed using an ELISA kit. The results of the study showed statistically significantly higher serum and liver concentration of SAA in the group of birds that received zinc sulfate in comparison to the group of birds receiving zinc in organic form. A statistically significantly higher serum concentration of CRP and α-1-AGP was also noted in the group receiving zinc sulfate as compared to the Zn-Gly group. Comparison of the serum concentration of TRF between the supplemented groups showed a statistically significant increase in this parameter in the ZnGly-F group as compared to the ZSO 4 -F group. The increase in the serum concentration of Hp in all groups in comparison to the control may indicate stimulation of local immune mechanisms. The results of this study showed an increase in the concentrations of APPs such as AGP and TRF following the administration of zinc glycine chelates, which may demonstrate their effect on metabolic processes in the liver and on immunocompetent cells that regulate the intensity of the immune response.

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“…This role for zinc in inflammation is shown by the finding of Saslov et al [1970] who demonstrated that radioactive zinc is concentrated in healing tissues with the peak of activity occurring on the first day after an injury. Our results also conform with the work of Fernandcz-Madrid et al [1976] in which they demonstrate that the regenera tion of fibroblasts during the inflammatory phase of wound healing is perturbed in zincdeficient rats and proliferation of these cells is not possible without DNA and RNA poly merases.…”

Section: Discussionmentioning

confidence: 92%

Comparison of the Anti-Inflammatory Activity of Sodium Acexamate and Zinc Acexamate in Healing Skin Wounds in Rabbits

et al. 1987

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After obtaining an abscess on the inner thigh of rabbits, the resulting inflammatory area was treated with sodium acexamate and zinc acexamate (0.5 ml s.c. of a 7% w/v solution). All animals received labeled leukocytes (¹¹¹In, 1 mCi, i.v.). The hyperfixation was measured by comparing the inflammatory areas. In the group treated with zinc acexamate, the regression of inflammation was highly significant (p < 0.001) in comparison with the other groups. These results emphasize the importance of combining zinc with acexamic acid for healing skin wounds.

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Radiozinc studies in experimental wound healing

Cited by 108 publications

References 4 publications

Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study

Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study

Effect of Zinc Sulfate and Zinc Glycine Chelate on Concentrations of Acute Phase Proteins in Chicken Serum and Liver Tissue

Comparison of the Anti-Inflammatory Activity of Sodium Acexamate and Zinc Acexamate in Healing Skin Wounds in Rabbits

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