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Using inductively coupled argon plasma emission spectroscopy, we measured 19 trace elements in cerebrospinal fluid of 265 patients who were undergoing diagnostic lumbar puncture. Thirty-three patients had Alzheimer-type dementia (ATD); 16 patients had other dementing illnesses; and 20 had no neurologic disease. There were seven cases of autopsy-proven Alzheimer's disease (AD) and eight autopsy controls. We found elevated CSF silicon in 24% of ATD and 71% of AD patients. We found no relationship between CSF aluminum, arsenic, lead, or manganese and ATD, AD, or other dementing illnesses.

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Elevated arsenic concentrations were found in ground water near Canal Fulton, Ohio. The hydrologie and chemical properties of the area were studied to determine the source of the arsenic and evaluate the possibility of a similar problem occurring elsewhere. Two major aquifer systems exist within the study area: the Sharon Sandstone of the upland areas; and the outwash sand and gravel deposits of the buried valleys. Ground‐water flow is generally from the north, but local variations are caused by the Tuscarawas River valley on the south and west of the study area. Within the study area, there is no evidence for an anthropogenic source of arsenic to the ground water. Agricultural soils, abandoned underground coal mines, industrial impoundments to the north, and an abandoned industrial dump site within the study area were all eliminated as possible sources for the arsenic. The arsenic in Canal Fulton ground water is entirely inorganic, consisting of about equal parts of arsenate and arsenite. Reduction‐oxidation (redox) considerations suggest that arsenic is controlled by an adsorption equilibrium with ferric hydroxides, and that the reduction of the ferric hydroxides by a recent lowering of Eh and/or pH in the aquifer has liberated both iron and arsenic to solution. A high correlation between ferrous iron and total dissolved arsenic supports this model. It is hypothesized that Eh conditions have been lowered in the aquifer by either the recent introduction of methane gas or the deposition of a thick layer of till during the last glacial retreat. The methane gas could be leaking from deep underground storage at the site and reducing oxidized compounds. The deposition of till would have eliminated local recharge of oxygenated waters.