2000
DOI: 10.2307/3454399
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Radon and Lung Cancer Risk: Taking Stock at the Millenium

Abstract: Radon is a well-established human carcinogen for which extensive data are available, extending into the range of exposures experienced by the general population. Mounting epidemiologic evidence on radon and lung cancer risk, now available from more than 20 different studies of underground miners and complementary laboratory findings, indicates that risks are linear in exposure without threshold. Radon is also a ubiquitous indoor air pollutant in homes, and risk projections imply that radon is the second leadin… Show more

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Cited by 9 publications
(7 citation statements)
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“…In the subsequent 20 years, we have gained an increasingly complete picture of the risks posed by indoor radon exposure. 25 A pooled analysis of data from 11 cohort studies of underground miners was carried out to estimate the risks of indoor radon, with complementary evidence gained from case-control studies of lung cancer in the general population. 18, 26 Elegant experimental models, involving irradiation of single cells with single alpha particles, provide results consistent with a linear nonthreshold relationship between typical concentrations of indoor radon and lung cancer risk.…”
Section: Some Problems Solvedmentioning
confidence: 99%
“…In the subsequent 20 years, we have gained an increasingly complete picture of the risks posed by indoor radon exposure. 25 A pooled analysis of data from 11 cohort studies of underground miners was carried out to estimate the risks of indoor radon, with complementary evidence gained from case-control studies of lung cancer in the general population. 18, 26 Elegant experimental models, involving irradiation of single cells with single alpha particles, provide results consistent with a linear nonthreshold relationship between typical concentrations of indoor radon and lung cancer risk.…”
Section: Some Problems Solvedmentioning
confidence: 99%
“…[1][2][3][4][5][6][7] Lung cancer is evidently a disease affected by environmental exposure. [8][9][10] Urban air contains carcinogens, 4 5 and urban/rural risk differences in lung cancer cannot be fully explained by differences in tobacco smoke exposure. 4 9 This could indicate that other urban exposures are important.…”
mentioning
confidence: 99%
“…The region of 0-50 cGy was selected for study as representing the dose probably most involved in the development of lung cancer arising from ␣ radiation in basements and from exposure to uranium by miners (8)(9)(10). High doses produce more mutations but also kill cells, so that cancer risk may be less than expected.…”
mentioning
confidence: 99%
“…It becomes necessary, therefore, to understand what effect this will have on genetic damage and repair in mammalian cells. Moreover, low-dose ␣ radiation originating from radon in basements of human dwellings has been implicated in a significant percentage of human lung cancer (8,10), and ␣ radiation originating from uranium has been associated with very high incidence of lung cancer in miners, particularly those who smoke cigarettes (11).…”
mentioning
confidence: 99%