Rage: A Novel Cellular Receptor for Advanced Glycation End Products

Schmidt, Ann Marie; Hori, Osamu; Cao, Rong; Yan, Shi Du; Brett, Jerold; Wautier, Jean‐Luc; Ogawa, Satoshi; Kuwabara, Kosuke; Matsumoto, Masayasu; Stern, David

doi:10.2337/diab.45.3.s77

Cited by 254 publications

(186 citation statements)

References 9 publications

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“…The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels (5). AGEs cause formation of greater amount of matrix metalloproteinase (MMP) as they induce the release of cytokines through a multistep process which leads to more MMP being secreted.…”

Section: Originalmentioning

confidence: 99%

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

Gupta

Garg

et al. 2016

J Oral Sci

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The present study was carried out to evaluate the effect of type 2 diabetes mellitus (DM) and smoking on periodontal parameters and on the levels of salivary matrix metalloproteinase (MMP-8). One hundred and twenty five subjects were divided into five groups: group 1, systemically and periodontally healthy subjects (n = 25); group 2, systemically healthy subjects but with chronic periodontitis (n = 25); group 3, subjects with type 2 DM and chronic periodontitis (n = 25); group 4, smokers with chronic periodontitis (n = 25); group 5, diabetic-smokers with chronic periodontitis (n = 25). MMP-8 level in saliva was estimated by enzyme linked immunosorbent assay (ELISA) using Quantikine human total MMP-8 immunoassay kit. The result showed that the clinical periodontal parameters and the mean levels of the salivary MMP-8 were significantly higher for diabetic-smokers than other study groups. A highly significant positive correlation (r) between MMP-8 and periodontal parameters was also observed in diabetic-smoker patients. The findings suggest that diabetic-smokers have increased periodontal breakdown and are associated with an increased extent and severity of periodontitis. (J Oral Sci 58, 1-6, 2016)

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Section: Originalmentioning

confidence: 99%

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

Gupta

Garg

et al. 2016

J Oral Sci

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“…In support of this hypothesis, recent immunological studies using anti-AGE antibodies in several human tissues suggest that AGEs may be involved in aging processes, diabetic complications, and atherosclerosis (85). AGEs have been postulated to modulate cellular function through binding to specific cell surface receptors termed RAGE (receptors for advanced glycation end-products) (86). The binding of AGEs to RAGE elicits several responses, such as induction of cytokines, cell growth in macrophages, and enhancement of anglogenesis, and results in induction of cellular oxidant stress (86,87).…”

Section: Glycation Hypothesis Of Aging and Its Potential Contributionmentioning

confidence: 88%

“…AGEs have been postulated to modulate cellular function through binding to specific cell surface receptors termed RAGE (receptors for advanced glycation end-products) (86). The binding of AGEs to RAGE elicits several responses, such as induction of cytokines, cell growth in macrophages, and enhancement of anglogenesis, and results in induction of cellular oxidant stress (86,87).…”

Section: Glycation Hypothesis Of Aging and Its Potential Contributionmentioning

confidence: 99%

Aging and atherosclerosis in human and nonhuman primates

Cefalu

Wagner

1997

AGE

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Atherosclerosis is a major age-related process and public health problem and its clinical manifestations (coronary heart disease [CHD] and cerebrovascular disease) continue to be responsible for approximately 50% ofaU deaths occurring annually. In addition, CHD is responsible for over 70 to 80% of deaths among men and women over 65 years old. As our population ages (35 million people over the age of 65 in the U.S. by the year 2030) and because of the increased morbidity and mortality associated with atherosclerosis, an understanding of the role of aging in the development of atherosclerosis is needed.Multiple risk factors such as smoking, gender, hypertension, and lipids contribute to the development of atherosclerosis. However, these risk factors in combination explain only about half of the individual variability in incidence of CHD, and it has been hypothesized that age-related conditions may play a role. To propectively evaluate the effects of age per se on atherosclerosis progression in humans would require observation over many years.Thus, animal models that are representative of both aging processes and atherosclerosis would be extremely valuable. As such, nonhuman primates have been used extensively in atherosclerosis research. However, studies that will specifically evaluate the role of aging per se in contributing to development of atherosclerosis in nonhuman primates have only recently been initiated.In this review, the contribution of nonhuman primates to atherosclerosis research will be discussed, as will the development of atherosclerosis in both human and nonhuman primates. In addition, a role for age-related conditions in atherosclerosis development in both human and nonhuman primates will be outlined.

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“…RAGE is involved in many inflammatory conditions [16][17][18][19]. RAGE is a pattern recognition receptor that binds AGE, among several ligands related to primary immunity [18][19].…”

Section: Introductionmentioning

confidence: 99%

“…RAGE is a pattern recognition receptor that binds AGE, among several ligands related to primary immunity [18][19]. AGEs may be endogenous and exogenous [9].…”

Section: Introductionmentioning

confidence: 99%

Advanced Glycation Endproducts form During Ovalbumin Digestion in the Presence of Fructose

Gugliucci

Bains

Caccavello

2017

Preprint

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Background: One mechanism by which fructose could exert deleterious effect in metabolism and inflammation is via its potency vis-à-vis de Maillard reaction. We employed simulated stomach and duodenum digestion of ovalbumin to test the hypothesis that indeed AGEs are formed by fructose during simulated digestion of an ubiquitous food protein with intrinsic allergenic potential and under model physiological conditions. Methods: OVA was subjected to simulated gastric and intestinal digestion using standard models, in presence of fructose or glucose (0-100 mM). Peptide fractions were analyzed by fluorescence spectroscopy and intensity at Excitation: λ370 nm, Emission: λ 440nm. Results: AGE adducts form between fructose and OVA which can be found in peptide fractions (< 5 kDa) at times (30 min) and concentration ranges (10 mM) plausibly found in the intestines, whereas no reaction occurs with glucose. The reaction is inhibited by chlorogenic acid at concentrations compatible with those found in the gut. The reaction is inhibited by AG, a specific antiglycation agent. Conclusion: Our proof of principle study shows that fructose-AGE formation on an ubiquitous allergenic protein indeed occurs in one hour and thereby may pave the way for the study of yet another mechanism by Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

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Rage: A Novel Cellular Receptor for Advanced Glycation End Products

Cited by 254 publications

References 9 publications

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

Aging and atherosclerosis in human and nonhuman primates

Advanced Glycation Endproducts form During Ovalbumin Digestion in the Presence of Fructose

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